Strategies for sustained drug release from electrospun multi‐layer nanostructures DOI
Deng‐Guang Yu, Menglong Wang, Ruiliang Ge

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2021, Volume and Issue: 14(3)

Published: Dec. 28, 2021

Abstract Among different kinds of modified release profiles, sustained drug (SDR) has received the most attention due to its capability provide a “safe, efficacious, and convenient” delivery effect. Electrospun nanofibers have shown their popularity in this interdisciplinary field, as demonstrated by first reports about SDRs on applications blended core–shell nanofibers. Along with evolution electrospinning from single‐fluid blending process coaxial, tri‐axial, side‐by‐side, other multi‐fluid processes, more multi‐chamber nanostructures can be created through single‐step straight forward manner. These act powerful platform support wide variety new strategies for development novel SDR nanomaterials. Thus, review describes combination history further trend. After summary presently popular nanostructures, 15 furnishing profiles are categorized exemplified. The perspectives electrospun promoting narrated. This article is under: Therapeutic Approaches Drug Discovery > Emerging Technologies

Language: Английский

Electrospun Nanofiber Membranes for Air Filtration: A Review DOI Creative Commons
Yangjian Zhou, Yanan Liu, Mingxin Zhang

et al.

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(7), P. 1077 - 1077

Published: March 25, 2022

Nanomaterials for air filtration have been studied by researchers decades. Owing to the advantages of high porosity, small pore size, and good connectivity, nanofiber membranes prepared electrospinning technology considered as an outstanding air-filter candidate. To satisfy requirements material functionalization, can provide a simple efficient one-step process fabricate complex structures functional nanofibers such core–sheath structures, Janus other multilayered structures. Additionally, nanoparticle carrier, electrospun easily achieve antibacterial properties, flame-retardant adsorption properties volatile gases, etc. These effective approaches benefited from significate development air-filtration applications. In this review, research progress on filters in recent years is summarized. The fabrication methods, performances, advantages, disadvantages single-polymer nanofibers, multipolymer composite nanoparticle-doped hybrid are investigated. Finally, basic principles concluded upon prospects application complex-structured field proposed.

Language: Английский

Citations

161

Structural and Functional Design of Electrospun Nanofibers for Hemostasis and Wound Healing DOI
Yutong Yang, Yuzhang Du, Jie Zhang

et al.

Advanced Fiber Materials, Journal Year: 2022, Volume and Issue: 4(5), P. 1027 - 1057

Published: June 30, 2022

Language: Английский

Citations

154

Advances in Biosensing and Environmental Monitoring Based on Electrospun Nanofibers DOI
Shixiong Kang, Kun Zhao, Deng‐Guang Yu

et al.

Advanced Fiber Materials, Journal Year: 2022, Volume and Issue: 4(3), P. 404 - 435

Published: April 25, 2022

Language: Английский

Citations

107

In Situ Electrospinning of Aggregation‐Induced Emission Nanofibrous Dressing for Wound Healing DOI
Ruihua Dong, Ying Li, Mian Chen

et al.

Small Methods, Journal Year: 2022, Volume and Issue: 6(5)

Published: Feb. 26, 2022

Rapid wound dressing and effective antibacterial therapy that meet the extreme requirements of emergency situations are urgently needed for treating skin wounds. Here, an in situ deposited personalized nanofibrous is reported which can be directly electrospun on wounds by a handheld electrospinning device perfectly fits different various sizes. Moreover, aggregation-induced emission luminogen with photodynamic effect loaded dressings endows dressing's long-term activity during healing process. The nanofibers show excellent antimicrobial against Staphylococcus aureus (S. aureus) methicillin-resistant aureus. In vivo studies demonstrate these effectively reduce inflammation significantly accelerate healing. Such produced promising as total solution emergencies, including patient-specific clinical military injuries.

Language: Английский

Citations

101

Polymer-Based Nanofiber–Nanoparticle Hybrids and Their Medical Applications DOI Open Access
Mingxin Zhang, Wenliang Song,

Yunxin Tang

et al.

Polymers, Journal Year: 2022, Volume and Issue: 14(2), P. 351 - 351

Published: Jan. 17, 2022

The search for higher-quality nanomaterials medicinal applications continues. There are similarities between electrospun fibers and natural tissues. This property has enabled to make significant progress in medical applications. However, limited tissue scaffolding When nanoparticles nanofibers combined, the composite material can perform more functions, such as photothermal, magnetic response, biosensing, antibacterial, drug delivery biosensing. To prepare nanofiber nanoparticle hybrids (NNHs), there two primary ways. electrospinning technology was used produce NNHs a single step. An alternate way is use self-assembly technique create fibers. paper describes creation of from routinely biocompatible polymer composites. Single-step procedures methodologies discuss preparation NNHs. It combines recent research discoveries focus on application release, engineering last years.

Language: Английский

Citations

94

Electrospun hierarchical structural films for effective wound healing DOI
Haixia Xu, Feiyang Zhang, Menglong Wang

et al.

Biomaterials Advances, Journal Year: 2022, Volume and Issue: 136, P. 212795 - 212795

Published: April 9, 2022

Language: Английский

Citations

90

Electrospun structural nanohybrids combining three composites for fast helicide delivery DOI
Hang Liu, Haibin Wang, Xuhua Lu

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2022, Volume and Issue: 5(2), P. 1017 - 1029

Published: May 30, 2022

Language: Английский

Citations

89

A review on polysaccharides mediated electrospun nanofibers for diabetic wound healing: Their current status with regulatory perspective DOI
Mohit Kumar, Ayah Rebhi Hilles, Yi Ge

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 234, P. 123696 - 123696

Published: Feb. 16, 2023

Language: Английский

Citations

85

Multifunctional and Smart Wound Dressings—A Review on Recent Research Advancements in Skin Regenerative Medicine DOI Creative Commons
Nithya Rani Raju, Ekaterina Silina, Stupin Va

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(8), P. 1574 - 1574

Published: July 28, 2022

The healing of wounds is a dynamic function that necessitates coordination among multiple cell types and an optimal extracellular milieu. Much the research focused on finding new techniques to improve manage dermal injuries, chronic burn sepsis, which are frequent medical concerns. A strategy involves developing multifunctional dressings aid innate combat numerous issues trouble incompletely healed such as extreme inflammation, ischemic damage, scarring, wound infection. Natural origin-based compounds offer distinct characteristics, excellent biocompatibility, cost-effectiveness, low toxicity. Researchers have developed biopolymer-based with drugs, biomacromolecules, cells cytocompatible, hemostatic, initiate skin rejuvenation rapid healing, possess anti-inflammatory antimicrobial activity. main goal would be mimic characteristics fetal tissue regeneration in adult phase, including complete hair glandular restoration without delay or scarring. Emerging treatments based biomaterials, nanoparticles, biomimetic proteases keys improving care will vital addition therapeutic toolkit for slow-healing wounds. This study focuses recent discoveries several undergone extensive pre-clinical development now undergoing fundamental research.

Language: Английский

Citations

81

Nanoparticles incorporated in nanofibers using electrospinning: A novel nano-in-nano delivery system DOI

Karishma Shetty,

Ayush Bhandari, Khushwant S. Yadav

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 350, P. 421 - 434

Published: Aug. 30, 2022

Language: Английский

Citations

81