Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(2), P. 273 - 273
Published: Jan. 24, 2022
Diabetes
mellitus
is
a
chronic
disease
with
high
mortality
rate
and
many
complications.
A
non-healing
diabetic
foot
ulcer
(DFU)
one
the
most
serious
complications,
leading
to
lower-extremity
amputation
in
15%
of
patients.
Nanofibers
are
emerging
as
versatile
wound
dressing
due
their
unique
healing
properties,
such
surface
area
volume
ratio,
porosity,
ability
maintain
moist
environment
capable
delivering
sustained
drug
release
oxygen
supply
wound.
The
present
study
was
aimed
prepare
evaluate
polyvinyl
alcohol
(PVA)-sodium
alginate
(SA)-silk
fibroin
(SF)-based
multifunctional
nanofibrous
scaffold
loaded
asiaticoside
(AT)
rats.
SEM
findings
showed
that
fibers'
diameters
ranged
from
100-200
nm,
tensile
strengths
12.41-16.80
MPa.
crosslinked
nanofibers
were
AT
over
an
extended
period.
MTT
scratch
assay
on
HaCat
cells
confirmed
low
cytotoxicity
significant
cell
migration,
respectively.
Antimicrobial
tests
revealed
excellent
anti-microbial
efficacy
against
P.
aeruginosa
S.
aureus
bacteria.
In-vivo
demonstrated
better
In
addition,
histopathological
studies
its
restore
normal
structure
skin.
concluded
developed
have
great
potential
for
applications.
Materials,
Journal Year:
2020,
Volume and Issue:
13(11), P. 2663 - 2663
Published: June 11, 2020
Chitosan
(CS)
has
gained
particular
attention
in
biomedical
applications
due
to
its
biocompatibility,
antibacterial
feature,
and
biodegradability.
Hence,
many
studies
have
focused
on
the
manufacturing
of
CS
films,
scaffolds,
particulate,
inks
via
different
production
methods.
Nowadays,
with
possibility
precise
adjustment
porosity
size
shape,
fiber
size,
suitable
interconnectivity
pores,
creation
patient-specific
constructs,
3D
printing
overcome
limitations
traditional
Therefore,
fabrication
printed
scaffolds
can
lead
promising
advances
tissue
engineering
regenerative
medicine.
A
review
additive
types,
CS-based
their
usages
as
biomaterials,
advantages,
drawbacks
open
doors
optimize
constructions
for
applications.
The
latest
technological
issues
upcoming
capabilities
biopolymers
are
also
discussed.
This
article
will
act
a
roadmap
aiming
investigate
chitosan
new
feedstock
concerning
various
approaches
which
may
be
employed
fields.
In
fact,
combination
is
extremely
appealing
particularly
regard
certain
clinical
purposes.
Complications
coupled
challenges
associated
materials
should
recognized
help
make
this
method
feasible
wider
requirements.
strategy
currently
gaining
substantial
terms
several
industrial
products.
review,
key
along
revealing
historical
background
initially
presented,
ultimately,
techniques
fabricating
constructs
recognition
essential
complications
technical
problems
related
numerous
biopolymer
choices
according
requirements
crucial.
comprehensive
investigation
required
encounter
those
completely
understand
possibilities
foreseeable
future.
Materials,
Journal Year:
2021,
Volume and Issue:
14(6), P. 1510 - 1510
Published: March 19, 2021
This
review
supplies
a
report
on
fresh
advances
in
the
field
of
silk
fibroin
(SF)
biopolymer
and
its
blends
with
biopolymers
as
new
biomaterials.
The
also
includes
subsection
about
mixtures
synthetic
polymers.
Silk
is
commonly
used
to
receive
However,
materials
based
pure
polymer
present
low
mechanical
parameters,
high
enzymatic
degradation
rate.
These
properties
can
be
problematic
for
tissue
engineering
applications.
An
increased
interest
two-
three-component
chemically
cross-linked
has
been
observed
due
their
improved
physico-chemical
properties.
attractive
desirable
both
academic,
and,
industrial
attention
because
they
expose
improvements
required
biomedical
field.
structure,
forms,
methods
preparation,
some
are
discussed
this
review.
Detailed
examples
given
from
scientific
reports
practical
experiments.
most
common
biopolymers:
collagen
(Coll),
chitosan
(CTS),
alginate
(AL),
hyaluronic
acid
(HA)
components
fibroin-based
mixtures.
Examples
binary
ternary
mixtures,
composites
addition
magnetic
particles,
hydroxyapatite
or
titanium
dioxide
included
given.
Additionally,
advantages
disadvantages
chemical,
physical,
cross-linking
were
demonstrated.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(2), P. 273 - 273
Published: Jan. 24, 2022
Diabetes
mellitus
is
a
chronic
disease
with
high
mortality
rate
and
many
complications.
A
non-healing
diabetic
foot
ulcer
(DFU)
one
the
most
serious
complications,
leading
to
lower-extremity
amputation
in
15%
of
patients.
Nanofibers
are
emerging
as
versatile
wound
dressing
due
their
unique
healing
properties,
such
surface
area
volume
ratio,
porosity,
ability
maintain
moist
environment
capable
delivering
sustained
drug
release
oxygen
supply
wound.
The
present
study
was
aimed
prepare
evaluate
polyvinyl
alcohol
(PVA)-sodium
alginate
(SA)-silk
fibroin
(SF)-based
multifunctional
nanofibrous
scaffold
loaded
asiaticoside
(AT)
rats.
SEM
findings
showed
that
fibers'
diameters
ranged
from
100-200
nm,
tensile
strengths
12.41-16.80
MPa.
crosslinked
nanofibers
were
AT
over
an
extended
period.
MTT
scratch
assay
on
HaCat
cells
confirmed
low
cytotoxicity
significant
cell
migration,
respectively.
Antimicrobial
tests
revealed
excellent
anti-microbial
efficacy
against
P.
aeruginosa
S.
aureus
bacteria.
In-vivo
demonstrated
better
In
addition,
histopathological
studies
its
restore
normal
structure
skin.
concluded
developed
have
great
potential
for
applications.
