Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

ACS Nano, Journal Year: 2021, Volume and Issue: 15(12), P. 18895 - 18930

Published: Dec. 6, 2021

Light is an attractive tool that has a profound impact on modern medicine. Particularly, light-based photothermal therapy (PTT) and photodynamic (PDT) show great application prospects in the prevention of wound infection promoting healing. In addition, hydrogels have shown advantages field dressings due to their excellent biochemical effects. Therefore, multifunctional photoresponsive (MPRHs) integrate light are increasingly used biomedicine, especially repair. However, comprehensive review MPRHs for regeneration still lacking. This first focuses various types prepared by diverse photosensitizers, agents (PHTAs) including transition metal sulfide/oxides nanomaterials, nanostructure-based PHTAs, carbon-based conjugated polymer or complex-based and/or (PHDAs) such as ZnO-based, black-phosphorus-based, TiO2-based, small organic molecule-based PHDAs. We also then discuss how PTT, PDT, photothermal/photodynamic synergistic can modulate microenvironments bacteria inhibit infection. Overall, with both therapeutic tissue capabilities been discussed existing challenges, well future research directions management argued.

Language: Английский

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Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies

Advanced Science, Journal Year: 2021, Volume and Issue: 8(19)

Published: Aug. 5, 2021

Healthcare-acquired infections as well increasing antimicrobial resistance have become an urgent global challenge, thus smart alternative solutions are needed to tackle bacterial infections. Antibacterial materials in biomedical applications and hospital hygiene attracted great interest, particular, the emergence of surface design strategies offer effective antibiotics, thereby preventing possible development resistance. In this review, recent progress on advanced modifications prevent addressed comprehensively, starting with key factors against adhesion, followed by varying that can inhibit biofilm formation effectively. Furthermore, "super antibacterial systems" through pre-treatment defense targeted bactericidal system, proposed evidence clinical potential. Finally, advantages future challenges resist healthcare-associated discussed, promising prospects developing novel materials.

Language: Английский

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Graphitic carbon nitride-based materials for photocatalytic antibacterial application

Materials Science and Engineering R Reports, Journal Year: 2021, Volume and Issue: 145, P. 100610 - 100610

Published: March 30, 2021

Language: Английский

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Photothermal antibacterial materials to promote wound healing

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 363, P. 180 - 200

Published: Sept. 27, 2023

Language: Английский

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Noble metal-based nanomaterials as antibacterial agents

Journal of Alloys and Compounds, Journal Year: 2022, Volume and Issue: 904, P. 164091 - 164091

Published: Feb. 4, 2022

Language: Английский

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Antibacterial gas therapy: Strategies, advances, and prospects

Bioactive Materials, Journal Year: 2022, Volume and Issue: 23, P. 129 - 155

Published: Nov. 11, 2022

One of the challenges posed by current antibacterial therapy is that expanded and massive use antibiotics endows bacteria with ability to resist almost all kinds antibiotics. Therefore, developing alternative strategies for efficient treatment urgently needed. Antibacterial gas has attracted much attention in past decade. Nitric oxide (NO), carbon monoxide (CO), sulfur dioxide (SO2), hydrogen sulfide (H2S), (H2) are not only known as endogenous signaling molecules, but also play critical roles many pathological processes. These gases considered attractive bactericidal agents because they able kill bacteria, disperse biofilms, promote bacteria-infected wound healing while avoiding resistance. In this review, we discuss properties these gases, well recent advances gas-involving systems antibacterial, antibiofilm, applications. Moreover, summarize various donors utilized treatment. We hope review will shed new light on future design applications advanced therapy.

Language: Английский

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Nanomaterials-based photothermal therapies for antibacterial applications

Materials & Design, Journal Year: 2023, Volume and Issue: 233, P. 112231 - 112231

Published: Aug. 9, 2023

Bacterial infection continues to be one of the biggest threats human health. The therapeutic effect is significantly reduced as a result development super-bacteria-resistant bacteria due overuse antibiotics for conventional antimicrobial treatment. emergence drug-resistant makes it necessary develop new treatments. Following successful application photothermal therapy in field oncology treatment, more and researchers are applying treatments achieving important results, especially treatment bacterial infections. As non-invasive anti-infection method, has advantages broad-spectrum properties, short period, low systemic impact. In PTT, efficacy strongly depends on different laser properties choice agents (PTAs). purpose this review discuss most recent developments nanomaterials that antibacterial. We will delve into principles spectrum PTAs provide summary current synthesis, classification, structural features, physicochemical antibacterial performance research. challenges future prospects enhanced cytotoxicity investigated.

Language: Английский

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Polysaccharide-based hydrogel with photothermal effect for accelerating wound healing

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 299, P. 120228 - 120228

Published: Oct. 14, 2022

Language: Английский

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Simultaneously enhancing the photocatalytic and photothermal effect of NH2-MIL-125-GO-Pt ternary heterojunction for rapid therapy of bacteria-infected wounds

Bioactive Materials, Journal Year: 2022, Volume and Issue: 18, P. 421 - 432

Published: March 29, 2022

Language: Английский

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Antimicrobial Peptides and Macromolecules for Combating Microbial Infections: From Agents to Interfaces

ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(2), P. 366 - 393

Published: Jan. 24, 2022

Bacterial resistance caused by the overuse of antibiotics and shelter biofilms has evolved into a global health crisis, which drives researchers to continuously explore antimicrobial molecules strategies fight against drug-resistant bacteria biofilm-associated infections. Cationic peptides (AMPs) are considered be category potential alternative for owing their excellent bactericidal potency lesser likelihood inducing drug through distinctive mechanisms. In this review, hitherto reported plentiful action modes AMPs systematically classified 15 types three categories (membrane destructive, nondestructive membrane disturbance, intracellular targeting mechanisms). Besides natural AMPs, cationic polypeptides, synthetic polymers, biopolymers enable achieve tunable properties optimizing structures. Subsequently, applications these agents at biointerface as contact-active surface coatings multifunctional wound dressings also emphasized here. At last, we provide our perspectives on development clinically significant antimicrobials related challenges in translation materials.

Language: Английский

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