Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(11), P. 7298 - 7310
Published: Oct. 8, 2024
Despite
the
increasing
interest
in
cellulose-derived
materials
biomedical
research,
there
remains
a
significant
gap
comprehensive
vivo
analyses
of
cellulosic
obtained
from
various
sources
and
processing
methods.
To
explore
durable
alternatives
to
synthetic
medical
meshes,
we
evaluated
biocompatibility
bacterial
nanocellulose,
regenerated
cellulose,
cellulose
nanofibrils
subcutaneous
transplantation
model,
alongside
incumbent
polypropylene
polydioxanone.
Notably,
this
study
demonstrates
through
alkali
dissolution
subsequent
regeneration.
All
implants
triggered
expected
foreign
body
response
host
tissue,
characterized
predominantly
by
macrophages
giant
cells.
Porous
promoted
cell
ingrowth
biointegration.
Our
results
highlight
potential
nanocellulose
as
safe
commercial
meshes.
However,
fragmentation
observed
for
nanofibril
meshes
suggests
need
measures
optimize
their
preparation.
Current Research in Green and Sustainable Chemistry,
Journal Year:
2024,
Volume and Issue:
8, P. 100412 - 100412
Published: Jan. 1, 2024
Nanocellulose
materials
are
distinguished
by
their
safety,
biodegradability,
and
adaptability.
It
was
shown
that
bacterial
nanocellulose
does
not
contain
lignin
hemicellulose
has
an
ultrafine
network
structure.
The
wide
compatibility
of
such
with
biological
molecules
the
ability
to
change
structure
makes
a
promising
material
for
medical
applications.
Today,
in
production
nanocellulose,
mainly
softwood
is
used.
Despite
obvious
advantages
limiting
factor
high
cost
wood
raw
environmental
damage
caused
deforestation.
Therefore,
there
increasing
interest
cheap
annually
renewable
herbaceous
plant
biomass,
which
potential
negative
synthesis
nanocellulose.
This
review
aimed
evaluate
viability
using
Miscanthus
genus
as
primary
source
characteristics
various
types
methods
preparation
from
miscanthus
discussed.
plants
disease
resistant,
frost
grow
rapidly.
biomass
growth
this
reaches
35
tons
per
hectare,
life
span
20
years.
crystals
because
it
rich
cellulose.
development
effective
obtaining
will
allow
introduction
new
class
biotechnical
composite
liquid
solid
compositions,
well
food,
medical,
pharmaceutical
industries.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(8)
Published: Dec. 29, 2023
Abstract
Bacterial
cellulose
is
an
extracellular
polysaccharide
produced
by
microorganisms,
offering
advantages
such
as
high
water‐holding
capacity,
flexibility,
and
biocompatibility.
However,
its
lack
of
bactericidal
activity
hampers
wide
application.
Usnic
acid,
a
secondary
metabolite
derived
from
lichens
the
Usnea
genus,
recognized
for
antibacterial
anti‐biofilm
efficiency,
coupled
with
anti‐inflammatory
properties.
Its
water
insolubility
presents
challenges
utilization
stable
release.
Sanxan
gel,
novel
polysaccharide,
exhibits
exceptional
freeze‐thaw
stability,
suspension
properties,
elasticity,
rendering
it
effective
suspending
agent
to
improve
bioavailability
water‐insoluble
drugs.
In
this
study,
hydrogel
membrane
designed
combining
bacterial
usnic
acid
suspended
in
sanxan
gel
through
simple
situ
microorganism
fermentation.
The
obtained
membranes
demonstrate
excellent
ability
sustained
drug
release,
strong
eradication
capability
against
tested
bacteria
both
vitro
vivo
experiments,
inhibition
biofilm
formation,
hemocompatibility
cytocompatibility.
Additionally,
composite
promote
wound
healing
reduced
inflammation
infection
full‐thickness
model
mice.
This
study
provides
innovative
insights
strategies
development
functional
dressings
infected
wounds
future
clinical
applications.
Materials & Design,
Journal Year:
2024,
Volume and Issue:
244, P. 113149 - 113149
Published: July 8, 2024
Bacterial
infections
and
inadequate
tissue
regeneration
capacity
are
prevalent
issues
in
diabetic
wounds,
impeding
the
healing
process.
To
solve
these
problems,
a
biomimetic
hydrogel
combined
with
bacterial
cellulose
(BC),
recombinant
human
collagen
type
III
(RHC),
ε-poly-L-Lysine
(EPL)
is
fabricated
by
stepwise
co-assembly
technology.
Owing
to
RHC
EPL
modifications
of
BC,
exhibited
antibacterial
effects
promoted
fibroblast
proliferation
angiogenesis,
which
accelerated
wounds.
Biomimetic
hydrogels
exhibit
good
mechanical
properties
excellent
water
absorption,
that
can
protect
wounds
provide
moist
environment.
In
addition,
vitro
studies
have
shown
activity
biocompatibility.
vivo
on
wound
promote
accelerate
deposition,
re-epithelialize
sites
healing.
This
study
provides
new
promising
strategy
for
treatment
Processes,
Journal Year:
2024,
Volume and Issue:
12(7), P. 1282 - 1282
Published: June 21, 2024
Bacterial
cellulose
(BC)
can
be
chemically
modified
and
combined
with
other
materials
to
create
composites
enhanced
properties.
In
the
medical
field,
biomaterials
offer
advantages,
such
as
biocompatibility
sustainability,
enabling
improved
therapeutic
strategies
patient
outcomes.
Incorporating
lidocaine
into
wound
dressings
offers
significant
potential
benefits.
this
study,
transparent
BC
films
were
produced
in
situ
an
undefined
minimal
culture
medium
a
yeast
bacteria
co-culture
system
on
black
tea
(Camellia
sinensis)
white
sugar
for
three
days.
Lidocaine
was
incorporated
ex
matrix,
composite
film
sterilized
using
gamma
radiation.
Drug-release
studies
showed
two-stage
release
profile,
initial
fast
(24.6%)
followed
by
slower
secondary
(27.2%
cumulative
release).
The
results
confirmed
incorporation
of
BC,
producing
highly
excellent
thermal
stability,
essential
storage
transportation
dressings.
This
study
highlighted
properties
drug
behavior.
findings
contribute
towards
optimizing
controlled
release,
showcasing
effective
platform
care
drug-delivery
applications.
