Antioxidants in cancer therapy mitigating lipid peroxidation without compromising treatment through nanotechnology DOI Creative Commons
Daniel Ejim Uti, Item Justin Atangwho, Esther Ugo Alum

et al.

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 24, 2025

Cancer treatments often exploit oxidative stress to selectively kill tumour cells by disrupting their lipid peroxidation membranes and inhibiting antioxidant enzymes. However, plays a dual role in cancer progression, acting as both promoter suppressor. Balancing through therapy remains challenge, excessive activity may compromise the efficacy of chemotherapy radiotherapy. This review explores antioxidants mitigating while maintaining treatment efficacy. It highlights recent advancements nanotechnology-based targeted delivery optimize therapeutic outcomes. A comprehensive literature was conducted using reputable databases, including PubMed, Scopus, Web Science, ScienceDirect. The search focused on publications from past five years (2020-2025), supplemented relevant studies earlier years. Keywords such "antioxidants," "lipid peroxidation," "nanotechnology therapy," "oxidative stress" were utilized. Relevant articles critically analysed, graphical illustrations created. Emerging evidence suggests that nanoparticles, liposomes, polymeric metal-organic frameworks, others, can effectively encapsulate control release minimizing systemic toxicity. Stimuli-responsive carriers with tumour-specific targeting mechanisms further enhance delivery. Studies indicate these strategies help preserve normal cells, mitigate stress-related damage, improve challenges bioavailability, stability, potential interactions standard therapies remain. Integrating nanotechnology antioxidant-based interventions presents promising approach for optimizing therapy. Future research should focus refining modulation strategies, assessing profiles during treatment, employing biomarkers determine optimal dosing. balanced use adverse effects.

Language: Английский

Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects DOI Creative Commons

Qin Ru,

Yusheng Li,

Lin Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Language: Английский

Citations

56
Iron homeostasis imbalance and ferroptosis in brain diseases DOI Creative Commons
Haining Long,

Wangshu Zhu,

Liming Wei

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(4)

Published: June 26, 2023

Brain iron homeostasis is maintained through the normal function of blood-brain barrier and regulation at systemic cellular levels, which fundamental to brain function. Excess can catalyze generation free radicals Fenton reactions due its dual redox state, thus causing oxidative stress. Numerous evidence has indicated diseases, especially stroke neurodegenerative are closely related mechanism imbalance in brain. For one thing, diseases promote accumulation. another, accumulation amplifies damage nervous system exacerbates patients' outcomes. In addition, triggers ferroptosis, a newly discovered iron-dependent type programmed cell death, neurodegeneration received wide attention recent years. this context, we outline metabolism focus on current stroke, Alzheimer's disease, Parkinson's disease. Meanwhile, also discuss ferroptosis simultaneously enumerate drugs for chelators inhibitors.

Language: Английский

Citations

43
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease DOI

Qian‐Kun Lv,

Kang‐Xin Tao,

Xiao‐Yu Yao

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(2)

Published: March 1, 2024

Abstract Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons and aggregation α‐synuclein (α‐syn). Ferroptosis, form cell death induced iron accumulation lipid peroxidation, involved in pathogenesis PD. It unknown whether melatonin receptor 1 (MT1) modulates α‐syn ferroptosis Here, we used preformed fibrils (PFFs) to induce PD models vivo vitro. In mice, led increased deposition ferroptosis. MT1 knockout exacerbated these changes resulted more DA neuronal severe motor impairment. also suppressed Sirt1/Nrf2/Ho1/Gpx4 pathway, reducing resistance ferroptosis, inhibited expression ferritin Fth1, leading release ferrous ions. vitro experiments confirmed findings. Knockdown enhanced PFF‐induced intracellular pathway Fth1 protein, thereby aggravating Conversely, overexpression reversed effects. Our findings reveal novel mechanism which activation prevents α‐syn‐induced PD, highlighting neuroprotective role

Language: Английский

Citations

27
Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors DOI Creative Commons

Carolina Punziano,

Silvia Trombetti, Elena Cesaro

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 298 - 298

Published: Feb. 28, 2024

Ferroptosis is a type of programmed cell death that differs from apoptosis, autophagy, and necrosis related to several physio-pathological processes, including tumorigenesis, neurodegeneration, senescence, blood diseases, kidney disorders, ischemia–reperfusion injuries. linked iron accumulation, eliciting dysfunction antioxidant systems, which favor the production lipid peroxides, membrane damage, ultimately, death. Thus, signaling pathways evoking ferroptosis are strongly associated with those protecting cells against excess and/or lipid-derived ROS. Here, we discuss interaction between metabolic particular focus on transcription factors implicated in regulation ferroptosis, either as triggers peroxidation or defense pathways.

Language: Английский

Citations

16
Ferroptosis role in complexity of cell death: unrevealing mechanisms in Parkinson’s disease and therapeutic approaches DOI
Anupam Awasthi,

Kousik Maparu,

Shamsher Singh

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

4
Updates in Alzheimer's disease: from basic research to diagnosis and therapies DOI Creative Commons

Enjie Liu,

Yao Zhang,

Jian–Zhi Wang

et al.

Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)

Published: Sept. 4, 2024

Language: Английский

Citations

15
Ferroptosis: a new antidepressant pharmacological mechanism DOI Creative Commons
Guangheng Zhang, Shimeng Lv, Xia Zhong

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

The incidence rate of depression, a mental disorder, is steadily increasing and has the potential to become major global disability factor. Given complex pathological mechanisms involved in use conventional antidepressants may lead severe complications due their side effects. Hence, there critical need explore development novel antidepressants. Ferroptosis, newly recognized form cell death, been found be closely linked onset depression. Several studies have indicated that certain active ingredients can ameliorate depression by modulating ferroptosis signaling pathway. Notably, traditional Chinese medicine (TCM) TCM prescriptions demonstrated promising antidepressant effects previous investigations owing unique advantages therapy. Building upon these findings, our objective was review recent relevant research provide new insights directions for application innovative strategies.

Language: Английский

Citations

11
Iron toxicity, ferroptosis and microbiota in Parkinson’s disease: Implications for novel targets DOI
Fernanda V. Carvalho,

Harold E. Landis,

Bruk Getachew

et al.

Advances in neurotoxicology, Journal Year: 2024, Volume and Issue: unknown, P. 105 - 132

Published: Jan. 1, 2024

Language: Английский

Citations

9
BSA-stabilized selenium nanoparticles ameliorate intracerebral hemorrhage's-like pathology by inhibiting ferroptosis-mediated neurotoxicology via Nrf2/GPX4 axis activation DOI Creative Commons
Xiaona Li, Li Lin, Xiaowei Li

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103268 - 103268

Published: July 17, 2024

Intracerebral hemorrhage (ICH) is a prevalent hemorrhagic cerebrovascular emergency. Alleviating neurological damage in the early stages of ICH critical for enhancing patient prognosis and survival rate. A novel form cell death called ferroptosis intimately linked to hemorrhage-induced brain tissue injury. Although studies have demonstrated significant preventive impact bovine serum albumin-stabilized selenium nanoparticles (BSA-SeNPs) against disorders connected system, neuroprotective effect on stroke mechanism remain unknown. Therefore, based favorable biocompatibility BSA-SeNPs, h-ICH (hippocampus-intracerebral hemorrhage) model was constructed perform BSA-SeNPs therapy. As expected, these could effectively improve cognitive deficits ameliorate hippocampal neuron. Furthermore, reverse morphology mitochondria enhanced mitochondrial function, evidenced by respiration function (OCR) membrane potential (MMP). Mechanistically, efficiently activate Nrf2 enhance expression antioxidant GPX4 at mRNA protein levels, further inhibit lipid peroxidation production erastin-induced ferroptotic damages. Taken together, this study not only sheds light clinical application but also provides its newly theoretical support strategy intervention treatment impairment following ICH.

Language: Английский

Citations

9
Ferroptosis: mechanisms and therapeutic targets DOI Creative Commons
Qian Zhou, Yu Meng,

Jiayuan Le

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 20, 2024

Ferroptosis is a nonapoptotic form of cell death characterized by iron-dependent lipid peroxidation in membrane phospholipids. Since its identification 2012, extensive research has unveiled involvement the pathophysiology numerous diseases, including cancers, neurodegenerative disorders, organ injuries, infectious autoimmune conditions, metabolic and skin diseases. Oxidizable lipids, overload iron, compromised antioxidant systems are known as critical prerequisites for driving overwhelming peroxidation, ultimately leading to plasma rupture ferroptotic death. However, precise regulatory networks governing ferroptosis ferroptosis-targeted therapy these diseases remain largely undefined, hindering development pharmacological agonists antagonists. In this review, we first elucidate core mechanisms summarize epigenetic modifications (e.g., histone modifications, DNA methylation, noncoding RNAs, N6-methyladenosine modification) nonepigenetic genetic mutations, transcriptional regulation, posttranslational modifications). We then discuss association between disease pathogenesis explore therapeutic approaches targeting ferroptosis. also introduce potential clinical monitoring strategies Finally, put forward several unresolved issues which progress needed better understand hope review will offer promise application therapies context human health disease.

Language: Английский

Citations

9