Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification

Bioactive Materials, Journal Year: 2021, Volume and Issue: 8, P. 220 - 240

Published: July 6, 2021

The considerable development of carrier-free nanodrugs has been achieved due to their high drug-loading capability, simple preparation method, and offering "all-in-one" functional platform features. However, the native defects limit delivery release behavior throughout in vivo journey, which significantly compromise therapeutic efficacy hinder further cancer treatment. In this review, we summarized discussed recent strategies enhance drug for improved therapy, including optimizing intrinsic physicochemical properties external modification. Finally, corresponding challenges that faced are future perspectives its application presented. We hope review will provide constructive information rational design more effective advance

Language: Английский

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Carrier-free nanodrugs for safe and effective cancer treatment

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 329, P. 805 - 832

Published: Oct. 9, 2020

Language: Английский

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Smart drug delivery systems for precise cancer therapy

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(11), P. 4098 - 4121

Published: Aug. 22, 2022

Language: Английский

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Carrier-Free Immunotherapeutic Nano-Booster with Dual Synergistic Effects Based on Glutaminase Inhibition Combined with Photodynamic Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(2), P. 1583 - 1596

Published: Jan. 3, 2023

The immunotherapeutic effect elicited by photodynamic therapy (PDT) is attenuated tumor defense mechanisms associated with glutamine metabolism, including the metabolic regulation of redox homeostasis and limitation immunosuppressive microenvironment (ITM). Herein, a carrier-free nanobooster C9SN dual synergistic effects was constructed self-assembly glutaminase (GLS) inhibitor compound 968 (C968) photosensitizer Chlorin e6. C968-mediated GSH deprivation through inhibiting metabolism prevented PDT-generated reactive oxygen species from being annihilated GSH, amplifying intracellular oxidative stress, which caused severe cell death also enhanced immunogenic (ICD) effect. In addition, genome-wide analysis carried out using RNA-sequencing to evaluate changes in transcriptome induced stress. Thereafter, neoantigens generated ICD promoted maturation dendritic cells, thereby recruiting activating cytotoxic T lymphocytes (CTLs). Meanwhile, remodeled ITM blocking polarize M2-type tumor-associated macrophages (TAMs) into M1-type TAMs, further recruited activated CTLs. Ultimately, this suppressed primary distant tumors. This "kill two birds one stone" strategy would shed light on enhancing immunogenicity alleviating immunosuppression improve PDT.

Language: Английский

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Molecularly self‐fueled nano-penetrator for nonpharmaceutical treatment of thrombosis and ischemic stroke

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 17, 2023

Thrombotic cerebro-cardiovascular diseases are the leading causes of disability and death worldwide. However, current drug therapeutics compromised by narrow therapeutic windows, unsatisfactory thrombolysis effects, severe bleeding events, high recurrence rates. In this study, we exploit a self-propelling nano-penetrator with fuel loading controllable motion features, which is molecularly co-assembled using photothermal photosensitizer (DiR) photothermal-activable NO donor (BNN6). The precisely engineered BNN6-DiR pair shows distinct advantages in terms productivity autonomous under laser irradiation. animal models artery/vein thrombosis acute ischemic stroke, self-fueled enables self-navigated thrombus-homing accumulation, self-propelled clot deep penetration, fluorescence image-guided photothermal/mechanical thrombolysis, NO-mediated prevention stroke salvage. As expected, displayed favorable outcomes without risk compared to clinically available thrombolytic drug. This study offers facile, safe, effective nonpharmaceutical modality towards clinical treatment stroke.

Language: Английский

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Smart transformable nanomedicines for cancer therapy

Biomaterials, Journal Year: 2021, Volume and Issue: 271, P. 120737 - 120737

Published: March 2, 2021

Language: Английский

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Elaborately Engineering a Self‐Indicating Dual‐Drug Nanoassembly for Site‐Specific Photothermal‐Potentiated Thrombus Penetration and Thrombolysis

Advanced Science, Journal Year: 2021, Volume and Issue: 9(4)

Published: Nov. 21, 2021

Abstract Thrombotic cardio‐cerebrovascular diseases seriously threaten human health. Currently, conventional thrombolytic treatments are challenged by the low utilization, inferior thrombus penetration, and high off‐target bleeding risks of most drugs, resulting in unsatisfactory treatment outcomes. Herein, it is proposed that these challenges can be overcome precisely integrating strategy with photothermal therapy. After co‐assembly engineering optimization, a fibrin‐targeting peptide‐decorated nanoassembly DiR (a probe) ticagrelor (TGL, an antiplatelet drug) prepared for thrombus‐homing delivery, abbreviated as FT‐DT NPs. The elaborately engineered shows multiple advantages, including simple preparation drug co‐loading capacity, synchronous delivery two drugs long systemic circulation, thrombus‐targeted accumulation self‐indicating function, well photothermal‐potentiated penetration thrombolysis therapeutic efficacy. As expected, NPs not only show bright fluorescence signals embolized vessels, but also perform photothermal/antiplatelet synergistic vivo. This study offers versatile co‐delivery nanoplatform imaging‐guided dual‐modality thrombolysis.

Language: Английский

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Emerging nanomedicines of paclitaxel for cancer treatment

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 342, P. 280 - 294

Published: Jan. 10, 2022

Language: Английский

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Carrier-Free Trehalose-Based Nanomotors Targeting Macrophages in Inflammatory Plaque for Treatment of Atherosclerosis

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 3808 - 3820

Published: Feb. 24, 2022

Inducing autophagy of macrophages to improve abnormal lipid metabolism is an important way treat atherosclerosis (AS). Yet, the current application mammalian target rapamycin (mTOR)-dependent inducers limited by side effects and lack targeting low biological availability. Herein, a kind nitric oxide (NO)-driven carrier-free nanomotor based on reaction between trehalose (Tr, one mTOR-independent inducers), L-arginine (Arg), phosphatidylserine (PS) reported. The developed nanomotors use NO as driving force, which generated from Arg excessive reactive oxygen species (ROS) inducible synthase (iNOS) specifically presenting in AS microenvironment. high expression ROS iNOS site can be used chemoattractants induce chemotaxis behavior achieve first-step plaque. Subsequently, "eat me" signal sent PS exploited precisely plaque, realizing plaque-macrophage-targeted effect this step-by-step strategy. In vitro vivo results confirm that introduction concept has greatly improved availability (the dose reduced 2.5 g kg-1 previous reports 0.01 work). Particularly, consumed production during process also play positive roles, former regulates M2 polarization latter promotes reconstruction endothelial barrier, contributes multilink treatment AS.

Language: Английский

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Emerging small molecule-engineered hybrid nanomedicines for cancer therapy

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 435, P. 135160 - 135160

Published: Feb. 9, 2022

Language: Английский

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