Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: May 14, 2024
The
flourishing
progress
in
nanotechnology
offers
boundless
opportunities
for
agriculture,
particularly
the
realm
of
nanopesticides
research
and
development.
However,
concerns
have
been
raised
regarding
human
environmental
safety
issues
stemming
from
unrestrained
use
non-therapeutic
nanomaterials
nanopesticides.
It
is
also
important
to
consider
whether
current
development
strategy
based
on
nanocarriers
can
strike
a
balance
between
investment
return,
if
complex
material
composition
genuinely
improves
efficiency,
safety,
circularity
Herein,
we
introduced
concept
with
minimizing
carriers
(NMC)
prepared
through
prodrug
design
molecular
self-assembly
emerging
as
practical
tools
address
limitations,
compared
it
employing
(NNC).
We
further
summarized
NMC
examined
potential
challenges
its
preparation,
performance,
production.
Overall,
asserted
that
systems
serve
innovative
driving
force
catalyzing
green
efficient
revolution
nanopesticides,
offering
way
out
predicament.
Drug Delivery,
Journal Year:
2022,
Volume and Issue:
29(1), P. 2130 - 2161
Published: July 10, 2022
Chemotherapy
drugs
have
been
used
for
a
long
time
in
the
treatment
of
cancer,
but
serious
side
effects
are
caused
by
inability
drug
to
be
solely
delivered
tumor
when
treating
cancer
with
chemotherapy.
Natural
products
attracted
more
and
attention
due
antitumor
effect
multiple
ways,
abundant
resources
less
effects.
Therefore,
combination
natural
active
ingredients
chemotherapy
may
an
effective
strategy,
which
can
inhibit
growth
multidrug
resistance,
reduce
drugs.
Nano-drug
co-delivery
system
(NDCDS)
play
important
role
This
review
provides
comprehensive
summary
research
status
application
prospect
nano-delivery
strategies
drugs,
aiming
provide
basis
development
anti-tumor
Bioactive Materials,
Journal Year:
2021,
Volume and Issue:
8, P. 220 - 240
Published: July 6, 2021
The
considerable
development
of
carrier-free
nanodrugs
has
been
achieved
due
to
their
high
drug-loading
capability,
simple
preparation
method,
and
offering
"all-in-one"
functional
platform
features.
However,
the
native
defects
limit
delivery
release
behavior
throughout
in
vivo
journey,
which
significantly
compromise
therapeutic
efficacy
hinder
further
cancer
treatment.
In
this
review,
we
summarized
discussed
recent
strategies
enhance
drug
for
improved
therapy,
including
optimizing
intrinsic
physicochemical
properties
external
modification.
Finally,
corresponding
challenges
that
faced
are
future
perspectives
its
application
presented.
We
hope
review
will
provide
constructive
information
rational
design
more
effective
advance
Journal of Materials Chemistry B,
Journal Year:
2022,
Volume and Issue:
10(12), P. 1908 - 1922
Published: Jan. 1, 2022
This
review
summarizes
the
research
progress
and
applications
of
different
types
self-assembled
nanodrug
delivery
systems,
which
are
expected
to
have
potential
therapeutic
value
in
field
biomedicine
future.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: March 25, 2023
Abstract
Nanomedicine
holds
great
promise
to
enhance
cancer
therapy.
However,
low
active
pharmaceutical
ingredient
(API)
loading
content,
unpredictable
drug
release,
and
potential
toxicity
from
excipients
limit
their
translational
capability.
We
herein
report
a
full-API
nanodrug
composed
of
FDA-approved
5-aminolevulinic
acid
(ALA),
human
essential
element
Fe
3+
,
natural
bioactive
compound
curcumin
with
an
ideal
API
content
pH-responsive
release
profile
for
continuous
spatiotemporal
therapy
achieved
by
multi-step
tandem
endogenous
biosynthesis.
First,
ALA
enzymatically
converts
into
photosensitizer
protoporphyrin
IX
(PpIX).
Afterward,
multiple
downstream
products
including
carbon
monoxide
(CO),
2+
biliverdin
(BV),
bilirubin
(BR)
are
individually
biosynthesized
through
the
PpIX-heme-CO/Fe
/BV-BR
metabolic
pathway,
further
cooperating
released
curcumin,
ultimately
eliciting
mitochondria
damage,
membrane
disruption,
intracytoplasmic
injury.
This
work
not
only
provides
paradigm
exploiting
diversified
metabolites
tumor
suppression,
but
also
presents
safe
efficient
nanodrug,
facilitating
practical
translation
nanodrugs.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(13), P. 12176 - 12187
Published: June 30, 2023
Spinal
cord
injury
(SCI),
which
is
characterized
by
excessive
inflammatory
cell
infiltration
and
accumulation
of
oxidative
substance,
would
severely
impede
neurological
functional
recovery
lead
to
permanent
profound
neurologic
deficits
even
disability.
Methylprednisolone
(MP)
the
most
commonly
used
clinical
anti-inflammatory
drug
for
SCI
treatment,
but
high
doses
are
typically
required
that
can
cause
severe
side
effects.
Here,
we
developed
a
carrier-free
thioketal
linked
MP
dimer@rutin
nanoparticles
(MP2-TK@RU
NPs)
achieve
combined
treatment
coassembling
reactive
oxygen
species
(ROS)
cleavable
dimers
rutin.
This
proposed
nanodrug
possesses
following
favorable
advantages:
(1)
system
easily
accessible
has
drug-loading
capacity,
preferred
pharmaceutical
industry;
(2)
The
ROS-cleavable
linker
increases
efficiency
targeted
delivery
site;
(3)
Rutin,
type
plant-derived
natural
flavonoid
with
good
biocompatibility,
anti-inflammatory,
antioxidant
properties,
codelivered
enhance
therapy
outcomes.
obtained
MP2-TK@RU
NPs
exhibited
potent
antioxidative
properties
both
in
vitro
vivo,
demonstrating
superior
locomotor
function
neuroprotective
efficacy
rats
SCI.
anticipated
provide
promising
therapeutic
strategy
treatment.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 541 - 569
Published: Jan. 1, 2024
Natural
products
have
proven
to
significant
curative
effects
and
are
increasingly
considered
as
potential
candidates
for
clinical
prevention,
diagnosis,
treatment.
Compared
with
synthetic
drugs,
natural
not
only
diverse
structures
but
also
exhibit
a
range
of
biological
activities
against
different
disease
states
molecular
targets,
making
them
attractive
development
in
the
field
medicine.
Despite
advancements
use
purposes,
there
remain
obstacles
that
hinder
their
full
potential.
These
challenges
include
issues
such
limited
solubility
stability
when
administered
orally,
well
short
durations
effectiveness.
To
address
these
concerns,
nano-drug
delivery
systems
emerged
promising
solution
overcome
barriers
faced
application
products.
offer
notable
advantages,
large
specific
surface
area,
enhanced
targeting
capabilities,
ability
achieve
sustained
controlled
release.
Extensive
vitro
vivo
studies
provided
further
evidence
supporting
efficacy
safety
nanoparticle-based
delivering
preclinical
models.
This
review
describes
limitations
product
applications
current
status
combined
nanotechnology.
The
latest
advances
from
three
aspects:
connecting
warheads,
self-assembly,
co-delivery.
Finally,
translation
nano-drugs
discussed.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(15)
Published: Jan. 18, 2024
Abstract
The
chemo‐regulation
abilities
of
chemotherapeutic
medications
are
appealing
to
address
the
low
immunogenicity,
immunosuppressive
lactate
microenvironment,
and
adaptive
immune
resistance
colorectal
cancer.
In
this
work,
proteolysis
targeting
chimera
(PROTAC)
BRD4
(dBET57)
is
found
downregulate
cancer
glycolysis
through
transcription
inhibition
c‐Myc,
which
also
inhibits
expression
programmed
death
ligand
1
(PD‐L1)
reverse
evasion
avoid
resistance.
Based
on
this,
self‐delivery
nano‐PROTACs
(designated
as
DdLD
NPs)
further
fabricated
by
self‐assembly
doxorubicin
(DOX)
dBET57
with
assistance
DSPE‐PEG
2000
.
NPs
can
improve
stability,
intracellular
delivery,
tumor
accumulation
DOX
dBET57.
Meanwhile,
effect
efficiently
destroy
cells
trigger
a
robust
immunogenic
cell
(ICD).
More
importantly,
effects
inhibit
reduce
production,
PD‐L1
degradation.
Taking
advantages
chemotherapy
ability,
systemically
activated
antitumor
immunity
suppress
primary
metastatic
progression
without
inducing
any
systemic
side
effects.
Such
may
provide
new
insight
for
chemotherapy‐enabled
immunotherapy.
