Nanoplastics induces oxidative stress and triggers lysosome-associated immune-defensive cell death in the earthworm Eisenia fetida DOI Creative Commons
Yanfei Zhou, Gang He, Hao Jiang

et al.

Environment International, Journal Year: 2023, Volume and Issue: 174, P. 107899 - 107899

Published: March 27, 2023

Nanoplastics (NPs) are increasingly perceived as an emerging threat to terrestrial environments, but the adverse impacts of NPs on soil fauna and mechanisms behind these negative outcomes remain elusive. Here, a risk assessment was conducted model organism (earthworm) from tissue cell. Using palladium-doped polystyrene NPs, we quantitatively measured nanoplastic accumulation in earthworm investigated its toxic effects by combining physiological with RNA-Seq transcriptomic analyses. After 42-day exposure, accumulated up 15.9 143.3 mg kg-1 for low (0.3 kg-1) high (3 dose groups, respectively. retention led decrease antioxidant enzyme activity reactive oxygen species (O2- H2O2), which reduced growth rate 21.3 %-50.8 % caused pathological abnormalities. These were enhanced positively charged NPs. Furthermore, observed that irrespective surface charge, after 2 h gradually internalized coelomocytes (∼0.12 μg per cell) mainly amassed at lysosomes. Those agglomerations stimulated lysosomal membranes lose stability even rupture, resulting impeded autophagy process cellular clearance, eventually coelomocyte death. In comparison negatively nanoplastics, exerted 83 higher cytotoxicity. Our findings provide better understanding how posed harmful have important implications evaluating ecological

Language: Английский

RONS and Oxidative Stress: An Overview of Basic Concepts DOI Creative Commons
Ana Karina Aranda‐Rivera, Alfredo Cruz‐Gregorio, Yalith Lyzet Arancibia‐Hernández

et al.

Oxygen, Journal Year: 2022, Volume and Issue: 2(4), P. 437 - 478

Published: Oct. 10, 2022

Oxidative stress (OS) has greatly interested the research community in understanding damaging processes occurring cells. OS is triggered by an imbalance between reactive oxygen species (ROS) production and their elimination antioxidant system; however, ROS function as second messengers under physiological conditions. are produced from endogenous exogenous sources. Endogenous sources involve mitochondria, nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), oxidases (NOXs), endoplasmic reticulum (ER), xanthine (XO), endothelial nitric oxide synthase (eNOs), others. In contrast, might be generated through ultraviolet (UV) light, ionizing radiation (IR), contaminants, heavy metals, among It can damage DNA, lipids, proteins if not controlled. To avoid oxidative damage, systems activated. present review, we focus on basic concepts of OS, highlighting nitrogen (RONS) derived internal external last elimination. Moreover, include cellular system regulation ability to decrease OS. External antioxidants also proposed alternatives ameliorate Finally, review diseases involving mechanisms.

Language: Английский

Citations

176
Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson’s disease-like neurodegeneration by causing energy metabolism disorders in mice DOI

Boxuan Liang,

Yuji Huang,

Yizhou Zhong

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 430, P. 128459 - 128459

Published: Feb. 11, 2022

Language: Английский

Citations

118
Oxidative Stress, Inflammation and Colorectal Cancer: An Overview DOI Creative Commons
Annamária Bardelčíková, Jindřich Šoltýs, Ján Mojžíš

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 901 - 901

Published: April 9, 2023

Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths worldwide. The pathogenesis CRC is a complex multistep process. Among other factors, inflammation and oxidative stress (OS) have been reported to be involved in initiation development CRC. Although OS plays vital part life all organisms, its long-term effects on human body may different chronic diseases, including diseases. Chronic can lead oxidation biomolecules (nucleic acids, lipids proteins) or activation inflammatory signaling pathways, resulting several transcription factors dysregulation gene protein expression followed by tumor cell survival. In addition, it well known that intestinal diseases such as bowel disease (IBD) are associated with an increased risk cancer, link between IBD progression has reported. This review focuses role causative agent colorectal cancer.

Language: Английский

Citations

109
An Overview: The Diversified Role of Mitochondria in Cancer Metabolism DOI Creative Commons
Yue Liu,

Yihong Sun,

Yadong Guo

et al.

International Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 19(3), P. 897 - 915

Published: Jan. 1, 2023

Mitochondria are intracellular organelles involved in energy production, cell metabolism and signaling.They essential not only the process of ATP synthesis, lipid nucleic acid metabolism, but also tumor development metastasis.Mutations mtDNA commonly found cancer cells to promote rewiring bioenergetics biosynthesis, various metabolites especially oncometabolites mitochondria regulate progression.And mutation enzymes TCA cycle leads unusual accumulation certain oncometabolites.Mitochondria have been demonstrated as target for treatment.Cancer rely on two main resources: oxidative phosphorylation (OXPHOS) glycolysis.By manipulating OXPHOS genes or adjusting production mitochondria, growth can be restrained.For example, enhanced complex I activity increases NAD + /NADH prevent metastasis progression cancers.In this review, we discussed mitochondrial function specially explored unique role stem microenvironment.Targeting pathway mitochondria-related emerging a potential therapeutic strategy cancers.

Language: Английский

Citations

106
Interaction of Mitochondrial Calcium and ROS in Neurodegeneration DOI Creative Commons
Artyom Y. Baev, Andrey Y. Vinokurov,

Irina N. Novikova

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(4), P. 706 - 706

Published: Feb. 17, 2022

Neurodegenerative disorders are currently incurable devastating diseases which characterized by the slow and progressive loss of neurons in specific brain regions. Progress investigation mechanisms these helped to identify a number genes associated with familial forms toxins risk factors trigger sporadic toxic diseases. Recently, some similarities neurodegenerative were identified, including involvement mitochondria, oxidative stress, abnormality Ca2+ signaling astrocytes. Thus, mitochondria produce reactive oxygen species during metabolism play further role redox signaling, but this may also act as an additional for abnormal mitochondrial calcium handling, resulting overload. Combinations can be neuronal cell death pathologies. Here, we review latest literature on crosstalk physiology beyond, considering how changes or convert interaction into pathological event.

Language: Английский

Citations

99
Nrf2 as a regulator of mitochondrial function: Energy metabolism and beyond DOI
Noemí Esteras, Andrey Y. Abramov

Free Radical Biology and Medicine, Journal Year: 2022, Volume and Issue: 189, P. 136 - 153

Published: July 31, 2022

Language: Английский

Citations

98
Lipid Peroxidation and Antioxidant Protection DOI Creative Commons
Luca Valgimigli

Biomolecules, Journal Year: 2023, Volume and Issue: 13(9), P. 1291 - 1291

Published: Aug. 24, 2023

Lipid peroxidation (LP) is the most important type of oxidative-radical damage in biological systems, owing to its interplay with ferroptosis and role secondary other biomolecules, such as proteins. The chemistry LP consequences are reviewed focus on kinetics various processes, which helps understand mechanisms efficacy antioxidant strategies. main types antioxidants discussed terms structure–activity rationalization, mechanism kinetics, well their potential modulating ferroptosis. Phenols, pyri(mi)dinols, based heavy chalcogens (Se Te), diarylamines, ascorbate others addressed, along latest unconventional strategies double-sided superoxide/hydroperoxyl radical system.

Language: Английский

Citations

89
Recent advances in small-molecule fluorescent probes for studying ferroptosis DOI
Ya‐Lin Qi, Hairong Wang, Lili Chen

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(18), P. 7752 - 7778

Published: Jan. 1, 2022

Ferroptosis is an iron-dependent, non-apoptotic form of programmed cell death driven by excessive lipid peroxidation (LPO). Mounting evidence suggests that the unique modality involved in development and progression several diseases including cancer, cardiovascular (CVDs), neurodegenerative disorders, etc. However, pathogenesis signalling pathways ferroptosis are not fully understood, possibly due to lack robust tools for highly selective sensitive imaging analytes complex living systems. Up now, various small-molecule fluorescent probes have been applied as promising chemosensors studying through tracking biomolecules or microenvironment-related parameters vitro vivo. In this review, we comprehensively reviewed recent ferroptosis, with a focus on analytes, design strategies bioimaging applications. We also provided new insights overcome major challenges emerging field.

Language: Английский

Citations

88
Nanoparticles assisted regulation of oxidative stress and antioxidant enzyme system in plants under salt stress: A review DOI
Muhammad Zia‐ur‐Rehman,

Sidra Anayatullah,

Effa Irfan

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 314, P. 137649 - 137649

Published: Dec. 29, 2022

Language: Английский

Citations

73
Mitochondria and Brain Disease: A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities DOI Creative Commons
Vicente Javier Clemente‐Suárez, Laura Redondo-Flórez, Ana Isabel Beltrán-Velasco

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2488 - 2488

Published: Sept. 7, 2023

Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated the pathogenesis various brain diseases, including neurodegenerative disorders, stroke, psychiatric illnesses. This review paper provides comprehensive overview intricate relationship between disease, focusing on underlying pathological mechanisms exploring potential therapeutic opportunities. The covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, dynamics, calcium dysregulation, reactive oxygen species generation context disease. Additionally, it discusses emerging strategies targeting dysfunction, protective agents, metabolic modulators, gene therapy approaches. By critically analysing existing literature recent advancements, this aims to enhance our understanding multifaceted disease shed light novel interventions.

Language: Английский

Citations

66