Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans

Nutrients, Journal Year: 2019, Volume and Issue: 11(6), P. 1234 - 1234

Published: May 30, 2019

Time-restricted feeding (TRF) is a form of intermittent fasting that involves having longer daily period. Preliminary studies report TRF improves cardiometabolic health in rodents and humans. Here, we performed the first study to determine how affects gene expression, circulating hormones, diurnal patterns risk factors Eleven overweight adults participated 4-day randomized crossover where they ate between 8 am 2 pm (early (eTRF)) (control schedule). Participants underwent continuous glucose monitoring, blood was drawn assess factors, expression whole cells. Relative control schedule, eTRF decreased mean 24-hour levels by 4 ± 1 mg/dl (p = 0.0003) glycemic excursions 12 3 0.001). In morning before breakfast, increased ketones, cholesterol, stress response aging SIRT1 autophagy LC3A (all p < 0.04), while evening, it tended increase brain-derived neurotropic factor (BNDF; 0.10) also MTOR 0.007), major nutrient-sensing protein regulates cell growth. altered cortisol several circadian clock genes 0.05). levels, alters lipid metabolism may have anti-aging effects

Language: Английский

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Effectiveness of Intermittent Fasting and Time-Restricted Feeding Compared to Continuous Energy Restriction for Weight Loss

Nutrients, Journal Year: 2019, Volume and Issue: 11(10), P. 2442 - 2442

Published: Oct. 14, 2019

The current obesity epidemic is staggering in terms of its magnitude and public health impact. Current guidelines recommend continuous energy restriction (CER) along with a comprehensive lifestyle intervention as the cornerstone treatment, yet this approach produces modest weight loss on average. Recently, there has been increased interest identifying alternative dietary strategies that involve restricting intake to certain periods day or prolonging fasting interval between meals (i.e., intermittent restriction, IER). These include (IMF; >60% 2-3 days per week, alternate days) time-restricted feeding (TRF; limiting daily period food 8-10 h less most week). Here, we summarize evidence for IER regimens treatments overweight obesity. Specifically, review randomized trials ≥8 weeks duration performed adults (BMI ≥ 25 kg/m2) which an paradigm (IMF TRF) was compared CER, primary outcome being loss. Overall, available suggests paradigms produce equivalent when 9 out 11 studies reviewed showing no differences groups body fat

Language: Английский

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Time-restricted Eating for the Prevention and Management of Metabolic Diseases

Endocrine Reviews, Journal Year: 2021, Volume and Issue: 43(2), P. 405 - 436

Published: Sept. 22, 2021

Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE, humans) are an emerging behavioral intervention approach based on the understanding of role circadian rhythms in physiology metabolism. In this approach, all calorie intake is restricted within a consistent interval less than 12 hours without overtly attempting to reduce calories. This article will summarize origin TRF/TRE starting with concept chronic rhythm disruption increasing risk for metabolic diseases. Circadian usually perceived as sleep-wake cycle dependent arising from central nervous system. However, recent discovery peripheral organs plasticity these response changes nutrition availability raised possibility that adopting daily short window can sustain robust rhythm. Preclinical animal studies have demonstrated proof identified potential mechanisms driving TRF-related benefits. Pilot human reported promising results reducing obesity, diabetes, cardiovascular Epidemiological indicated maintaining long overnight fast, which similar TRE, significantly risks Despite early successes, more clinical mechanistic needed implement TRE alone or adjuvant lifestyle prevention management

Language: Английский

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Beneficial Effects of Time-Restricted Eating on Metabolic Diseases: A Systemic Review and Meta-Analysis

Nutrients, Journal Year: 2020, Volume and Issue: 12(5), P. 1267 - 1267

Published: April 29, 2020

Various behavioral and physiological pathways follow a pre-determined, 24 hour cycle known as the circadian rhythm. Metabolic homeostasis is regulated by Time-restricted eating (TRE) type of intermittent fasting based on In this study, we aim to analyze systemically effects TRE body weight, composition, other metabolic parameters. We reviewed articles from PubMed, EMBASE, Cochrane Library identify clinical trials that compared regular diet. included 19 studies for meta-analysis. Participants following showed significantly reduced weight (mean difference (MD), −0.90; 95% confidence interval (CI): −1.71 −0.10) fat mass (MD: −1.58, CI: −2.64 −0.51), while preserving fat-free (MD, −0.24; −1.15 0.67). also beneficial cardiometabolic parameters such blood pressure (systolic BP, MD, −3.07; −5.76 −0.37), glucose concentration −2.96; CI, −5.60 −0.33), cholesterol profiles (triglycerides, MD: −11.60, −23.30 −0.27). conclusion, promising therapeutic strategy controlling improving dysfunctions in those who are overweight or obese. Further large-scale needed confirm these findings usefulness TRE.

Language: Английский

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Feeding Rhythms and the Circadian Regulation of Metabolism

Frontiers in Nutrition, Journal Year: 2020, Volume and Issue: 7

Published: April 17, 2020

The molecular circadian clock regulates metabolic processes within the cell, and alignment of these clocks between tissues is essential for maintenance homeostasis. possibility misalignment arises from differential responsiveness to environmental cues that synchronize (zeitgebers). Although light dominant cue master suprachiasmatic nucleus, many other are sensitive feeding fasting. When rhythms behaviour altered, example by shift work or constant availability highly palatable foods, strong feedback sent peripheral clocks. Varying degrees phase can cause systemic processes. Moreover, when there a endogenous in physiology inputs, such as during inactive phase, body's ability maintain homeostasis impaired. loss coordination organism environment, well internal tissues, produce cardiometabolic disease consequence. aim this review synthesize on mechanisms effects misalignment. timing food intake highlighted powerful with potential destroy restore synchrony metabolism.

Language: Английский

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Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation

iScience, Journal Year: 2020, Volume and Issue: 23(6), P. 101161 - 101161

Published: May 15, 2020

Eating out of phase with daily circadian rhythms induces metabolic desynchrony in peripheral organs and may increase chronic disease risk. Time-restricted eating (TRE) is a dietary approach that consolidates all calorie intake to 6- 10-h periods during the active day, without necessarily altering diet quality quantity. TRE reduces body weight, improves glucose tolerance, protects from hepatosteatosis, increases flexibility, atherogenic lipids blood pressure, gut function cardiometabolic health preclinical studies. This review discusses importance meal timing on system, benefits models humans, possible mechanisms action, challenges we face implementing consequences delaying initiation TRE.

Language: Английский

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Food Timing, Circadian Rhythm and Chrononutrition: A Systematic Review of Time-Restricted Eating’s Effects on Human Health

Nutrients, Journal Year: 2020, Volume and Issue: 12(12), P. 3770 - 3770

Published: Dec. 8, 2020

Introduction: Recent observations have shown that lengthening the daily eating period may contribute to onset of chronic diseases. Time-restricted (TRE) is a diet especially limits this food window. It could represent dietary approach likely improve health markers. The aim study was review how time-restricted affects human health. Method: Five general databases and six nutrition journals were screened identify all studies published between January 2014 September 2020 evaluating effects TRE on populations. Results: Among 494 articles collected, 23 finally included for analysis. overall adherence rate 80%, with 20% unintentional reduction in caloric intake. induced an average weight loss 3% fat mass. This also observed without any restriction. Interestingly, produced beneficial metabolic independently loss, suggesting intrinsic effect based realignment feeding circadian clock. Conclusions: simple well-tolerated generates many chrononutrition principles. More rigorous are needed, however, confirm those effects, understand their mechanisms assess applicability

Language: Английский

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Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults

GeroScience, Journal Year: 2020, Volume and Issue: 42(2), P. 667 - 686

Published: Jan. 23, 2020

Language: Английский

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The role of nutrition in inflammaging

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 77, P. 101596 - 101596

Published: Feb. 24, 2022

Language: Английский

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Effect of time restricted eating on body weight and fasting glucose in participants with obesity: results of a randomized, controlled, virtual clinical trial

Nutrition and Diabetes, Journal Year: 2021, Volume and Issue: 11(1)

Published: Jan. 15, 2021

Time restricted eating (TRE) is an emerging dietary intervention for weight loss that hypothesized to reinforce the metabolic benefits of nightly fasting/ketosis. This pilot study investigated effectiveness a daily 14-h fast (14:10 TRE beginning after dinner, "fasting snack" at hour 12, and ending with breakfast 14 h later) combined commercial management program on body fasting blood glucose (FBG) in individuals obesity. We also effect low-calorie, high-fat, low-carbohydrate, low-protein glucose.This 8-week, randomized, controlled, clinical trial included men women (BMI ≥ 30 kg/m2) between June October 2020. Study procedures were conducted remotely. Participants randomized 14:10 or 12-h (12:12, active comparator) prescribed diet (controlled calories macronutrient composition) exercise weekly customized counseling support. The primary outcome was change from baseline group.Of 78 participants, 60 (n = 30/group) completed 8 weeks. LS mean group -8.5% (95% CI -9.6 -7.4; P < 0.001) -7.1% (-8.3 -5.8; 12:12 (between difference -1.4%; -2.7 -0.2; 0.05). There statistically significant week FBG -7.6 mg/dl -15.1 -0.1; 0.05) but not (-3.1 mg/dl, -10.0 3.7; NS). Both interventions resulted larger reduction participants elevated (≥100 mg/dl) (both 0.05).In obesity who weeks schedule program, there clinically meaningful improvements FBG.

Language: Английский

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