Impact of Intermittent Fasting Combined With High-Intensity Interval Training on Body Composition, Metabolic Biomarkers, and Physical Fitness in Women With Obesity DOI Creative Commons
Gabriela Batitucci,

Eli V. Faria,

Jonatas E. Nogueira

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: May 26, 2022

Intermittent fasting (IF) is a dietary approach that widely popular due to its effects on weight and body fat loss, but it does not appear ensure muscle mass preservation. Incorporating high-intensity interval training (HIIT) into an individual's routine could be attractive viable therapeutic option for improving composition, lifestyle health promotion. Problematizing the emerging situation of fighting obesity, led us clarify gaps about IF hypothesize HIIT in conjunction may protect against decline without impairing nitrogen balance (NB), addition physical fitness women with obesity.To evaluate alone combined NB strength obesity.Thirty-six (BMI 34.0 ± 3.2; 32.2 4.4 years) participated were randomly distributed three groups: (1) exercise group (IF + EX); (2) Exercise (EX); (3) (IF). The interventions took place over 8 weeks all evaluations performed pre post-intervention. circuit was 3x/week, 25 mins/session, at 70-85% maximum heart rate. intermittent protocol 5:2 diet two meals within 6 h days, being 25% total energy intake, plus 18 complete fasting. 2x/week 5 days ad libitum ingestion. Resting metabolic rate (RMR) measured by indirect calorimetry, composition BodPod®, from urinary nitrogen, food consumption records performance tests. ANOVA two-way repeated measures mixed model followed Sidak post hoc (p < 0.05). This project registered ClinicalTrials.gov, NCT05237154.There reduction (P = 0.012) BMI 0.031) only EX group. There loss (-4%, P 0.001) (-2.3%, 0.043), increase fat-free (+3.3%, also (+2%, differences between groups showed no changes. equilibrium groups. All parameters aerobic capacity improved.Combining can promote increments mass, improve strength.

Language: Английский

Intermittent fasting in the prevention and treatment of cancer DOI
Katherine Clifton, X. Cynthia, Luigi Fontana

et al.

CA A Cancer Journal for Clinicians, Journal Year: 2021, Volume and Issue: 71(6), P. 527 - 546

Published: Aug. 12, 2021

Abstract Chronic caloric restriction (CR) has powerful anticarcinogenic actions in both preclinical and clinical studies but may be difficult to sustain. As an alternative CR, there been growing interest intermittent fasting (IF) the scientific lay community as a result of promising study results, mainly experimental animal models. According survey by International Food Information Council Foundation, IF become most popular diet last year, patients with cancer are seeking advice from oncologists about its beneficial effects for prevention treatment. However, discussed this review, results rodents controversial suggest potential detrimental certain oncologic conditions. The on human incidence prognosis remain unknown because lack high‐quality randomized trials. Preliminary that prolonged some who have is safe potentially capable decreasing chemotherapy‐related toxicity tumor growth. additional trials needed elucidate risks benefits cancer, authors would not currently recommend undergoing active treatment partake outside context trial. considered adults cancer‐prevention through means weight management, whether itself affects cancer‐related metabolic molecular pathways remains unanswered.

Language: Английский

Citations

131
Prolonged, Controlled Daytime versus Delayed Eating Impacts Weight and Metabolism DOI Creative Commons
Kelly C. Allison, Christina M. Hopkins,

Madelyn Ruggieri

et al.

Current Biology, Journal Year: 2020, Volume and Issue: 31(3), P. 650 - 657.e3

Published: Nov. 30, 2020

Language: Английский

Citations

75
Obesity-Related Chronic Kidney Disease: Principal Mechanisms and New Approaches in Nutritional Management DOI Creative Commons
Alessandra Stasi, Carmela Cosola, Gianvito Caggiano

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: June 24, 2022

Obesity is the epidemic of our era and its incidence supposed to increase by more than 30% 2030. It commonly defined as a chronic metabolic disease with an excessive accumulation body fat in relation fat-free mass, both terms quantity distribution at specific points on body. The effects obesity have important impact different clinical areas, particularly endocrinology, cardiology, nephrology. Indeed, increased rates been associated risk cardiovascular (CVD), cancer, type 2 diabetes (T2D), dyslipidemia, hypertension, renal diseases, neurocognitive impairment. Obesity-related kidney (CKD) has ascribed intrarenal along proximal tubule, glomeruli, sinus, around capsule, hemodynamic changes hyperfiltration, albuminuria, impaired glomerular filtration rate. In addition, diabetes, which arise consequence overweight, contribute amplifying dysfunction native transplanted kidney. Overall, several mechanisms are closely related onset progression CKD general population, including hemodynamics, neurohumoral pathways, adiposity, local systemic inflammation, dysbiosis microbiota, insulin resistance, fibrotic process. Unfortunately, there no practice guidelines for management patients obesity-related CKD. Therefore, dietary based nutritional care adults CKD, developed published National Kidney Foundation, Disease Outcome Quality Initiative common recommendations healthy population. Optimal these should follow Mediterranean diet, known be lower CVD beneficial diseases such obesity, cognitive health. Mediterranean-style diets often unsuccessful promoting efficient weight loss, especially altered glucose metabolism. For this purpose, review also discusses use non-classical loss approaches intermittent fasting ketogenic diet contrast

Language: Английский

Citations

56
The Effects of Intermittent Fasting and Continuous Energy Restriction with Exercise on Cardiometabolic Biomarkers, Dietary Compliance, and Perceived Hunger and Mood: Secondary Outcomes of a Randomised, Controlled Trial DOI Open Access
Stephen Keenan, Matthew B. Cooke, Won Sun Chen

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(15), P. 3071 - 3071

Published: July 26, 2022

(1) Background: Excess weight in the form of adiposity plays a key role pathogenesis cardiometabolic diseases. Lifestyle modifications that incorporate continuous energy restriction (CER) are effective at inducing loss and reductions adiposity; however, prescribing daily CER results poor long-term adherence. Over past decade, intermittent fasting (IF) has emerged as promising alternative to may promote increased compliance and/or improvements health parameters independent loss. (2) Methods: This paper presents secondary analysis data from 12-week intervention investigating effects twice-weekly fast (5:2 IF; IFT group) (CERT when combined with resistance exercise 34 healthy participants (17 males 17 females, mean BMI: 27.0 kg/m2, age: 23.9 years). Specifically, changes blood markers ratings hunger, mood, within between groups were analysed. Dietary prescriptions hypoenergetic matched for protein intake. (3) Results: Both dietary experienced total cholesterol (TC; reduction, 7.8%; p < 0.001), low-density lipoprotein (LDL-C; 11.1%; 0.001) high-density (mean reduction 2.6%, = 0.049) over 12 weeks. Reductions TC LDL-C greater group after adjustment baseline levels change weight. No significant glucose regulation observed. maintained high (~80%) reported low hunger course period. (4) Conclusions: Secondary revealed training, both patterns improved lipids, observed group. High throughout period suggest diets well tolerated short-to-medium term.

Language: Английский

Citations

45
Complex physiology and clinical implications of time-restricted eating DOI
Max C. Petersen,

Molly R. Gallop,

Stephany Flores Ramos

et al.

Physiological Reviews, Journal Year: 2022, Volume and Issue: 102(4), P. 1991 - 2034

Published: July 14, 2022

Time-restricted eating (TRE) is a dietary intervention that limits food consumption to specific time window each day. The effect of TRE on body weight and physiological functions has been extensively studied in rodent models, which have shown considerable therapeutic effects important interactions among eating, circadian biology, metabolic homeostasis. In contrast, it difficult make firm conclusions regarding the people because heterogeneity results, regimens, study populations. this review, we 1) provide background history meal normal physiology fasting; 2) discuss interaction between molecular metabolism TRE; 3) integrate results preclinical clinical studies evaluated functions; 4) summarize other time-related interventions people; identify current gaps knowledge framework for future research directions.

Language: Английский

Citations

42
Fasting: From Physiology to Pathology DOI Creative Commons
Dongmei Tang,

Qiuyan Tang,

Wei Huang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(9)

Published: Feb. 3, 2023

Overnutrition is a risk factor for various human diseases, including neurodegenerative metabolic disorders, and cancers. Therefore, targeting overnutrition represents simple but attractive strategy the treatment of these increasing public health threats. Fasting as dietary intervention combating has been extensively studied. practiced millennia, only recently have its roles in molecular clock, gut microbiome, tissue homeostasis function emerged. can slow aging most species protect against These centuried unfading adventures explorations suggest that fasting potential to delay help prevent treat diseases while minimizing side effects caused by chronic interventions. In this review, recent animal studies concerning role underlying mechanism physiology pathology are summarized, therapeutic highlighted, combination pharmacological discussed new regimen diseases.

Language: Английский

Citations

39
Reflection on Ramadan Fasting Research Related to Sustainable Development Goal 3 (Good Health and Well-Being): A Bibliometric Analysis DOI

Katia H. AbuShihab,

Khaled Obaideen, Mohamad Alameddine

et al.

Journal of Religion and Health, Journal Year: 2023, Volume and Issue: 63(5), P. 3329 - 3359

Published: Dec. 18, 2023

Language: Английский

Citations

29
Intermittent fasting and longevity: From animal models to implication for humans DOI
Olha Strilbytska,

Svitlana Klishch,

Kenneth B. Storey

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102274 - 102274

Published: March 17, 2024

Language: Английский

Citations

11
Effects of Time-Restricted Feeding and Ramadan Fasting on Body Weight, Body Composition, Glucose Responses, and Insulin Resistance: A Systematic Review of Randomized Controlled Trials DOI Open Access
Sofia Tsitsou, Nikolaos Zacharodimos, Kalliopi‐Anna Poulia

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(22), P. 4778 - 4778

Published: Nov. 11, 2022

Time-restricted feeding (TRF) and Ramadan fasting (RF) have been recently associated with several health outcomes. However, it is not yet clear if they are superior to existing treatments in terms of glucose metabolism, insulin action, weight loss. This review aims summarize the current data on effects these regimes body weight, composition, glycemia. An electronic search was conducted PUBMED SCOPUS databases up August 2022. Twenty-four records met inclusion criteria underwent a risk-of-bias assessment. The main outcomes were: (a) TRF may result moderate loss individuals overweight/obesity; when combined caloric restriction, >5% initial (b) 14 h be as effective 16 loss, (c) lead improved sensitivity glycemic responses/variability throughout day overweight/obesity. Concerning RF, only two studies were available thus, conclusions drawn. an nutritional approach for amelioration control more long-term, well-designed needed.

Language: Английский

Citations

38
Effects of Intermittent Fasting on Cardiometabolic Health: An Energy Metabolism Perspective DOI Open Access
Manuel Dote‐Montero, Guillermo Sánchez‐Delgado, Éric Ravussin

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(3), P. 489 - 489

Published: Jan. 23, 2022

This review summarizes the effects of different types intermittent fasting (IF) on human cardiometabolic health, with a focus energy metabolism. First, we discuss coordinated metabolic adaptations (energy expenditure, hormonal changes and macronutrient oxidation) occurring during 72 h fast. We then studies investigating IF expenditure substrate oxidation. Finally, how may be optimized by combining it exercise. In general, regimens improve body composition, ectopic fat, classic risk factors, as compared to unrestricted eating, especially in metabolically unhealthy participants. However, is still unclear whether provides additional benefits continuous daily caloric restriction (CR). Most found no benefits, yet some preliminary data suggest that provide absence weight loss. although CR appear induce similar differentially affect oxidation, increasing protein fat Future tightly controlled are needed unravel underlying mechanisms its role health

Language: Английский

Citations

36