Gut microbiome remodeling and metabolomic profile improves in response to protein pacing with intermittent fasting versus continuous caloric restriction

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 28, 2024

Abstract The gut microbiome (GM) modulates body weight/composition and gastrointestinal functioning; therefore, approaches targeting resident microbes have attracted considerable interest. Intermittent fasting (IF) protein pacing (P) regimens are effective in facilitating weight loss (WL) enhancing composition. However, the interrelationships between IF- P-induced WL GM unknown. current randomized controlled study describes distinct fecal microbial plasma metabolomic signatures combined IF-P ( n = 21) versus a heart-healthy, calorie-restricted (CR, 20) diet matched for overall energy intake free-living human participants (women 27; men 14) with overweight/obesity 8 weeks. Gut symptomatology improves abundance of Christensenellaceae circulating cytokines amino acid metabolites favoring fat oxidation increase (p < 0.05), whereas associated longevity-related metabolic pathway CR 0.05). Differences indicate factors play role maintenance This novel work provides insight into profile following an or highlights important differences assembly composition responsiveness. These data may inform future GM-focused precision nutrition recommendations using larger sample sizes longer duration. Trial registration, March 6, 2020 (ClinicalTrials.gov as NCT04327141), based on previous intervention trial.

Language: Английский

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The pathophysiology of visceral adipose tissues in cardiometabolic diseases

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 222, P. 116116 - 116116

Published: March 8, 2024

Language: Английский

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Molecular Mechanisms of Healthy Aging: The Role of Caloric Restriction, Intermittent Fasting, Mediterranean Diet, and Ketogenic Diet—A Scoping Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2878 - 2878

Published: Aug. 28, 2024

As the population ages, promoting healthy aging through targeted interventions becomes increasingly crucial. Growing evidence suggests that dietary can significantly impact this process by modulating fundamental molecular pathways. This review focuses on potential of strategies in and mechanisms which specific nutrients patterns influence key pathways involved cellular repair, inflammation, metabolic regulation. Caloric restriction, intermittent fasting, Mediterranean diet, as well ketogenic diet showed promising effects aging, possibly mTORC1 AMPK, an insulin signaling pathway. By understanding intricate interplay between pathways, we develop personalized not only prevent age-related diseases, but also promote overall health well-being throughout process.

Language: Английский

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Time-restricted feeding improves metabolic syndrome by activating thermogenesis in brown adipose tissue and reducing inflammatory markers

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Background Obesity and metabolic syndrome (MetS) have become increasingly significant global health issues. Time-restricted feeding (TRF), as a novel dietary intervention, has garnered attention in recent years. However, there is limited research focusing on the effects of TRF energy expenditure systemic low-grade inflammation. This study aims to investigate impact weight management, glucose metabolism, insulin resistance, lipid metabolism male C57BL/6J mice, particularly context disorders induced by high-fat diet (HFD). Methods mice were divided into two groups: normal (ND) group (HFD) group. The duration was 12 weeks. Key parameters observed included body weight, tolerance (via tests), resistance (HOMA-IR), secretion under stimulation. Additionally, liver tissue subjected Oil Red O staining assess accumulation, white brown adipose tissues stained with hematoxylin eosin (HE) evaluate adipocyte size. expression hepatic lipogenesis-related genes (Srebp-c, Chrebp, Fasn, Acc1) thermogenic (UCP1 PGC-1α) also measured. Furthermore, temperature changes interscapular (BAT) monitored. Results In ND group: improved reduced circulating levels pro-inflammatory cytokine IL-6, slight reduction weight.In HFD significantly mitigated gain, enhanced steatosis downregulating liver. increased thermogenesis upregulating BAT, while lowering serum cytokines IL-6 TNF-α, though IL-1β remained unchanged. Conclusion demonstrates that can activate reduce inflammation maker, leading an improvement accumulation. These findings suggest may be promising intervention for mitigating disturbances associated obesity syndrome. provides mechanistic insights beneficial TRF, highlighting its potential modulating exerting anti-inflammatory effects.

Language: Английский

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Obesity and malnutrition in children and adults: A clinical review

Obesity Pillars, Journal Year: 2023, Volume and Issue: 8, P. 100087 - 100087

Published: Sept. 7, 2023

In the U.S., children and adults are consuming more low-nutrient foods with added sugar excess fats as compared to healthy, high-quality calories micronutrients. This diet is increasing prevalence of malnutrition nutritional deficiencies, despite high calorie intake. a review common micronutrient risk factors for malnutrition, dietary plans, health consequences in obesity U.S.

Language: Английский

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Intermittent fasting and protein pacing are superior to caloric restriction for weight and visceral fat loss

Obesity, Journal Year: 2022, Volume and Issue: 31(S1), P. 139 - 149

Published: Dec. 27, 2022

Abstract Objective This study compared intermittent fasting and protein pacing (IF‐P) versus a heart‐healthy caloric restriction (CR) diet, matched for energy intake physical activity expenditure, on body weight, total visceral fat mass, cardiometabolic health outcomes in adults with obesity. Methods IF‐P ( n = 21) CR 20) were assessed pre‐ (week 0), mid‐ 5), post‐ 9) intervention. Results Both groups reduced p < 0.05) blood pressure lipids, desire to eat food increased proportion of fat‐free mass. resulted greater reductions weight (−9% vs. −5%), (−16% −9%) (−33% −14%) (−17% 1%) mass percent (6% 3%) CR. These improvements despite similar weekly (IF‐P, 9470 ± 550 CR, 9095 608 kcal/wk; 0.90) expenditure 300 150 350 200 kcal/d; 0.79). Conclusions optimize loss, composition, health, hunger management, providing benefits.

Language: Английский

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Metabolic changes with intermittent fasting

Journal of Human Nutrition and Dietetics, Journal Year: 2023, Volume and Issue: 37(1), P. 256 - 269

Published: Oct. 3, 2023

Abstract Background The prevalence of obesity is rising globally and effective strategies to treat are needed. Intermittent fasting, a dietary intervention for weight management, has received growing interest from the general public, as well healthcare professionals, form lifestyle intervention. Methods We executed rapid review using PUBMED database identify systematic reviews that examined impact intermittent fasting on metabolic indices, published between 2011 2022. Results leads loss similar magnitude continuous energy restriction. Most evidence shows greater fat measured by mass (kg) or body percentage compared an ad libitum diet, but attained during not significantly different restriction, although recent be superior. There mixed insulin resistance, glucose lipid profile. Some studies focused populations Muslim people, which showed Ramadan may lead improvement parameters effects reversed when finished. Conclusions more than intake, equally management. However, there inconclusive whether clinically beneficial effect metabolism.

Language: Английский

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Therapeutic Potential of Various Intermittent Fasting Regimens in Alleviating Type 2 Diabetes Mellitus and Prediabetes: A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2692 - 2692

Published: Aug. 14, 2024

Intermittent fasting has drawn significant interest in the clinical research community due to its potential address metabolic complications such as obesity and type 2 diabetes mellitus. Various intermittent regimens include alternate-day (24 h of followed by 24 eating), time-restricted (fasting for 14 eating within a 10 window), 5:2 diet two days normally other five days). is associated with reduced risk mellitus-related can slow their progression. The increasing global prevalence mellitus highlights importance early management. Since prediabetes precursor mellitus, understanding progression essential. However, long-term effects on are not yet well understood. Therefore, this review aims comprehensively compile existing knowledge therapeutic managing prediabetes.

Language: Английский

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The Effect of the 14:10-Hour Time-Restricted Feeding (TRF) Regimen on Selected Markers of Glucose Homeostasis in Diet-Induced Prediabetic Male Sprague Dawley Rats

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 292 - 292

Published: Jan. 15, 2025

Background: Prediabetes is a condition that often precedes the onset of type 2 diabetes mellitus (T2DM). Literature evidence indicates prediabetes reversible, making it an important therapeutic target for preventing progression to T2DM. Several studies have investigated intermittent fasting as possible method manage or treat prediabetes. Objectives: This study evaluated impact 14:10-hour time-restricted feeding (TRF) regimen on leptin concentration, insulin sensitivity and selected markers associated with signalling pathway glucose homeostasis in diet-induced prediabetic rats. Methods: Twenty-four male Sprague Dawley rats were obtained randomly divided into two dietary groups: group 1 (n = 6) received standard diet water, while 18) was provided high-fat, high-carbohydrate (HFHC) supplemented 15% fructose period 20 weeks induce After confirming prediabetes, (IF) assigned also having untreated metformin-treated serving controls. Results: Both IF HFHC-Met groups yield significantly lower blood glucose, BMI results compared group. The yielded insulin, HOMA-IR HbA1C than both Conclusions: showed potential alleviating prediabetes-induced dysregulation therefore warrants further investigations its use management

Language: Английский

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Effects of induced molting on lipid accumulation in liver of aged laying hens

Poultry Science, Journal Year: 2025, Volume and Issue: 104(4), P. 104941 - 104941

Published: Feb. 22, 2025

Language: Английский

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