Phytocannabinoids in the Pharmacotherapy of Psoriasis DOI Creative Commons
Adam Wroński, Iwona Jarocka-Karpowicz, Anna Stasiewicz

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1192 - 1192

Published: Jan. 25, 2023

Phytocannabinoids are naturally occurring compounds, the main source of which is Cannabis sativa L. Through direct action or interaction with G protein-coupled receptors, they affect ROS and pro-inflammatory cytokines levels modify effectiveness transcription factor responsible for biosynthesis antioxidants lead to oxidative stress its consequences. Due modification redox balance inflammation, phytocannabinoids used in treatment various diseases, including autoimmune dermatoses, such as atopic dermatitis psoriasis. Psoriasis one most common unknown etiology. A disturbed a shift towards oxidation leads stress, resulting modifications, mainly lipids proteins, prolonged activation immune cells increased generation cytokines, chronic inflammation. Given biological activity phytocannabinoids, have become focus research components pharmacotherapy Beneficial effects were shown by representatives but effect cannabidiol (CBD) on skin (in vitro ex vivo) blood from patients psoriasis vulgaris psoriatic arthritis has been often evaluated recent years.

Language: Английский

Diversity of molecular targets and signaling pathways for CBD DOI Creative Commons
Douglas Lamounier de Almeida, Lakshmi A. Devi

Pharmacology Research & Perspectives, Journal Year: 2020, Volume and Issue: 8(6)

Published: Nov. 9, 2020

Abstract Cannabidiol (CBD) is the second most abundant component of Cannabis plant and known to have effects distinct from Δ 9 ‐tetrahydrocannabinol (THC). Many studies that examined behavioral CBD concluded it lacks psychotomimetic attributed THC. However, was shown a broad spectrum on several conditions such as anxiety, inflammation, neuropathic pain, epilepsy. It currently thought engages different targets hence CBD’s are be due multiple molecular mechanisms action. A well‐accepted set include GPCRs ion channels, with serotonin 5‐HT 1A receptor transient potential cation channel TRPV1 being two main targets. has also been target G protein‐coupled receptors (GPCRs) cannabinoid opioid receptors. Other suggested role for additional channels CBD. Currently, clinical efficacy not completely understood. Evidence derived randomized trials, in vitro vivo models real‐world observations support use drug treatment option neuropathy, many other conditions. Hence an understanding current status field relates great interest so, this review, we findings recent highlight these

Language: Английский

Citations

196
Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years DOI Open Access
Mauro Maccarrone, Vincenzo Di Marzo, Jürg Gertsch

et al.

Pharmacological Reviews, Journal Year: 2023, Volume and Issue: 75(5), P. 885 - 958

Published: May 10, 2023

The cannabis derivative marijuana is the most widely used recreational drug in Western world and consumed by an estimated 83 million individuals (∼3% of population). In recent years, there has been a marked transformation society regarding risk perception cannabis, driven its legalization medical use many states United States worldwide. Compelling research evidence Food Drug Administration cannabis-derived cannabidiol approval for severe childhood epilepsy have confirmed large therapeutic potential itself, Δ

Language: Английский

Citations

90
A Comprehensive Review on the Techniques for Extraction of Bioactive Compounds from Medicinal Cannabis DOI Creative Commons
H.M.S. Al Ubeed, Deep Jyoti Bhuyan,

Muhammad A. Alsherbiny

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(3), P. 604 - 604

Published: Jan. 18, 2022

is well-known for its numerous therapeutic activities, as demonstrated in pre-clinical and clinical studies primarily due to bioactive compounds. The

Language: Английский

Citations

88
Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use DOI Open Access
Nicoleta Mirela Blebea, Andreea Pricopie, Robert-Alexandru Vlad

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4204 - 4204

Published: April 10, 2024

Phytocannabinoids, a diverse group of naturally occurring compounds extracted from the Cannabis plant, have attracted interest due to their potential pharmacological effects and medicinal uses. This comprehensive review presents intricate profiles phytocannabinoids while exploring impacts these substances on biological systems. From more than one hundred cannabinoids which were identified in plant so far, cannabidiol (CBD) tetrahydrocannabinol (THC) are two most extensively studied phytocannabinoids. CBD is non-psychoactive compound, exhibits anti-inflammatory, neuroprotective, anxiolytic properties, making it promising candidate for wide array medical conditions. THC, known its psychoactive effects, possesses analgesic antiemetic contributing therapeutic potential. In addition THC CBD, range additional shown intriguing including cannabichromene (CBC), cannabigerol (CBG), cannabinol (CBN). The endocannabinoid system, made up enzymes involved production breakdown endocannabinoids, cannabinoid receptors (CB1 CB2), endogenous ligands (endocannabinoids), essential preserving homeostasis several physiological processes. Beyond ability modify ion channels, neurotransmitter receptors, anti-oxidative pathways. complex interaction between systems offers hope novel treatment approaches lays groundwork further developments field cannabinoid-based medicine. summarizes state field, points out information gaps, emphasizes need studies fully realize

Language: Английский

Citations

17
Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses DOI Creative Commons
Kenneth B. Walsh,

Amanda E. McKinney,

Andrea E. Holmes

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Nov. 29, 2021

The medicinal use of Cannabis sativa L. can be traced back thousands years to ancient China and Egypt. While marijuana has recently shown promise in managing chronic pain nausea, scientific investigation cannabis been restricted due its classification as a schedule 1 controlled substance. A major breakthrough understanding the pharmacology came with isolation characterization phytocannabinoids trans-Δ9-tetrahydrocannabinol (Δ9-THC) cannabidiol (CBD). This was followed by cloning cannabinoid CB1 CB2 receptors 1990s subsequent discovery endocannabinoid system. In addition phytocannabinoids, Δ9-THC CBD, produces over 120 other cannabinoids that are referred minor and/or rare cannabinoids. These produced smaller amounts plant derived along CBD from parent cannabigerolic acid (CBGA). our current knowledge is incomplete, studies demonstrate they act agonists antagonists at multiple targets including receptors, transient receptor potential (TRP) channels, peroxisome proliferator-activated (PPARs), serotonin 5-HT1a others. resulting activation cell signaling pathways, combined their putative synergistic activity, provides mechanistic basis for therapeutic actions. Initial clinical reports suggest these may have benefits treatment neuropathic pain, neurodegenerative diseases, epilepsy, cancer skin disorders. review focuses on molecular highlights some important uses compounds.

Language: Английский

Citations

97
Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity DOI Creative Commons
Mohammad‐Reza Ghovanloo, Koushik Choudhury, Tagore Sanketh Bandaru

et al.

The Journal of General Physiology, Journal Year: 2021, Volume and Issue: 153(5)

Published: April 9, 2021

Cannabidiol (CBD) is the primary nonpsychotropic phytocannabinoid found in Cannabis sativa, which has been proposed to be therapeutic against many conditions, including muscle spasms. Among its putative targets are voltage-gated sodium channels (Navs), have implicated conditions. We investigated effects of CBD on Nav1.4, skeletal Nav subtype. explored direct effects, involving physical block pore, as well indirect modulation membrane elasticity that contributes inhibition. MD simulations revealed CBD’s localization inside and bilayer properties. Nuclear magnetic resonance (NMR) confirmed these results, showing localizing below headgroups. To determine functional implications findings, we used a gramicidin-based fluorescence assay show alters or thickness, could alter function through bilayer-mediated regulation. Site-directed mutagenesis vicinity Nav1.4 pore removing local anesthetic binding site with F1586A reduces INa by CBD. Altering fenestrations bilayer-spanning domain Nav1.4-WWWW blocked access from into (as judged MD). The stabilization inactivation, however, persisted WWWW, ascribe CBD-induced changes elasticity. investigate potential value channelopathies, pathogenic variant, P1158S, causes myotonia periodic paralysis. excitability both wild-type P1158S variant. Our vitro silico results suggest may hyperexcitability.

Language: Английский

Citations

60
The Origin and Biomedical Relevance of Cannabigerol DOI Open Access

Anna Jastrząb,

Iwona Jarocka-Karpowicz, Elżbieta Skrzydlewska

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(14), P. 7929 - 7929

Published: July 19, 2022

The constant search for new pharmacologically active compounds, especially those that do not exhibit toxic effects, intensifies the interest in plant-based ingredients and their potential use pharmacotherapy. One of plants has great therapeutic is

Language: Английский

Citations

57
The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation DOI Creative Commons
A. P. Young,

Eileen M. Denovan‐Wright

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 12

Published: Feb. 4, 2022

Microglia, the resident immune cells of brain, can take on a range pro- or anti-inflammatory phenotypes to maintain homeostasis. However, sustained activation pro-inflammatory microglia lead state chronic neuroinflammation characterized by high concentrations neurotoxic soluble factors throughout brain. In healthy brains, inflammatory processes cease and transition an phenotype, but failure halt is characteristic many neurological disorders. The endocannabinoid system has been identified as promising therapeutic target for there evidence that synthetic endogenously produced cannabinoids temper response may encourage switch phenotype. Activation cannabinoid type 2 (CB2) receptors proposed mechanism action responsible these effects. abundance components in also change dynamically several brain pathologies. This impact ability synthesize degrade endocannabinoids react endogenous exogenous cannabinoids. Cannabinoid participate formation receptor heteromers which influences their function specifically express both receptors, such microglia. creates opportunities drug-drug interactions between CB2 receptor-targeted therapies other classes drugs. this article, we review roles development resolution neuroinflammation. We discuss fluctuations observed examine potential context.

Language: Английский

Citations

55
The Anti-Inflammatory Effects of Cannabidiol (CBD) on Acne DOI Creative Commons
Nadia Peyravian, Sapna K. Deo, Sylvia Daunert

et al.

Journal of Inflammation Research, Journal Year: 2022, Volume and Issue: Volume 15, P. 2795 - 2801

Published: May 1, 2022

Abstract: Acne is the most common skin condition in United States and affects approximately 85% of people ages 12– 24. As a multifactorial disease, pathogenesis acne involves overproduction sebum, irregular shedding cutaneous cells, accretion Cutibacterium acnes at pilosebaceous unit, inflammation. To date, conventional therapies for include topical retinoids, over-the-counter bactericidal agents, systematic treatments, such as oral antibiotics isotretinoin. However, potential significant side effects risk antibiotic resistance remain limitations these therapies, turn reducing patient compliance adherence to treatment regimens. Therefore, use natural plant-derived treatments or phytotherapeutics an alternative adjuvant attractive patients due their safety minimal effects. Cannabidiol (CBD) non-psychoactive phytocannabinoid Cannabis sativa (hemp) plant. The therapeutic CBD has been implicated many diseases with inflammatory aspect, including cancers, neurodegeneration, immunological disorders, dermatological diseases. remains novel window opportunity. Herein, we summarize available relevant data, highlighting its anti-inflammatory properties. that extent, other cannabis constituents seeds were found reduce inflammation expression cytokines TNF-α IL-1β when evaluated acne-like conditions. Treatment extracts was also be safe well tolerated, further strengthening prospect acne. Keywords: cannabidiol, CBD, acne, inflammation,

Language: Английский

Citations

52
Extracellular vesicles of cannabis with high CBD content induce anticancer signaling in human hepatocellular carcinoma DOI Creative Commons

Tahereh Tajik,

Kaveh Baghaei,

Vahid Erfani Moghadam

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 152, P. 113209 - 113209

Published: June 3, 2022

Plant-derived extracellular vesicles (EVs) have been the topic of interest in recent years due to their proven therapeutic properties. Intact or manipulated plant EVs shown antioxidant, anti-inflammatory, and anti-cancerous activities as a result containing bioactive metabolites other endogenous molecules. Less is known about EV efficacy with high levels secondary derived from medicinal non-edible plants. Numerous data suggest functionality Cannabis sativa extract its phytocannabinoids cancer treatment. Here, two chemotypes cannabis different D-9-tetrahydrocannabinol (THC) cannabidiol (CBD) were selected. isolated each chemotype via differential ultracentrifugation. HPLC analysis was illustrative absence THC both Therefore, types classified according CBD content into high- (H.C-EVs) low-CBD (L.C-EVs). Electron microscopy DLS showed cannabis-derived (CDEVs) can be considered exosome-like nanovesicles. Cytotoxicity assay that H.C-EVs strongly decreased viability hepatocellular carcinoma (HCC) cell lines, HepG2 Huh-7, dose time-dependent manner compared L.C-EVs. had no significant effect on HUVECs normal growth. The finding arrested G0/G1 phase cycle significantly induced death by activating mitochondrial-dependent apoptosis signaling pathways HCC lines. Altogether, current study highlights CDEVs an ideal natural vehicle for promising strategy management.

Language: Английский

Citations

50