Plant extracellular vesicles: A promising bionic medicine platform for disease treatment and drug delivery DOI Creative Commons
Jichun Yang, Yuhan Wang,

Yunqian Fu

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Plant extracellular vesicles (PEVs) are nanoscale secreted by plant cells with intact membrane architecture, which encapsulate a diverse array of biomolecules, including lipids, proteins and RNA. They integral to both intra‐cellular communication within plants inter‐species signaling. Recently, some PEVs have been regarded as competitive candidates for disease therapy due their beneficial components distinctive hollow biomembrane structure. However, the broader applications currently impeded several challenges complicated extraction processes, compositional heterogeneity, lack reliable biomarkers unclear mechanisms. A detailed comprehension preparation techniques biological functions is essential leveraging potential in clinical medicine. This article first presented synthesis current methodologies PEV isolation, purification characterization. Then, it revealed therapeutic implications medicines common diseases based on bioactive molecules inside, such cancer, inflammation, metabolic disorders. We especially explored emerging role low immunogenicity power barriers crossing drug delivery systems, underscoring further industry applications. At last, bottleneck problems vision were also evoke more insightful deliberation. review aims provide directions development PEV‐derived innovative drugs.

Language: Английский

Current understanding of plant-derived exosome-like nanoparticles in regulating the inflammatory response and immune system microenvironment DOI Creative Commons

Qiaoli Yi,

Zhijie Xu, Abhimanyu Thakur

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 190, P. 106733 - 106733

Published: March 15, 2023

Natural compounds are widely used to prevent and treat various diseases due their antioxidant anti-inflammatory effects. As a kind of promising natural compound, plant-derived exosome-like nanoparticles (PELNs) extracted from multivesicular bodies edible plants, including vegetables, foods, fruits, mainly regulate the cellular immune response pathogen attacks. Moreover, PELNs could remarkably interfere with dynamic imbalance between pro-inflammatory effects, facilitating maintain homeostasis microenvironment. may serve as better alternative animal-derived exosomes (ADEs) owing widespread sources, cost-effectiveness, easy accessibility. can mediate interspecies communication by transferring cargoes such proteins, lipids, nucleic acids plant cells mammalian cells. This review summarizes biogenesis, composition, classification exosomes; common separation, purification, characterization methods PELNs, potential advantages over ADEs; immunomodulatory functions in colitis, cancer, inflammation-associated metabolic diseases. Additionally, future perspectives challenges associated clinical application discussed.

Language: Английский

Citations

87
A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy DOI Open Access
Jian Li, Ye Zhang,

Pei-Yu Dong

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115087 - 115087

Published: June 29, 2023

All forms of life produce nanosized extracellular vesicles called exosomes, which are enclosed in lipid bilayer membranes. Exosomes engage cell-to-cell communication and participate a variety physiological pathological processes. function via their bioactive components, delivered to target cells the form proteins, nucleic acids, lipids. as drug delivery vehicles due unique properties innate stability, low immunogenicity, biocompatibility, biodistribution, accumulation desired tissues, toxicity normal stimulation anti-cancer immune responses, penetration capacity into distance organs. mediate cellular communications by delivering various molecules including oncogenes, oncomiRs, specific DNA, messenger RNA (mRNA), microRNA (miRNA), small interfering (siRNA), circular (circRNA). These substances can be transferred change transcriptome influence tumor-related signaling pathways. After considering all available literature, this review we discuss biogenesis, composition, production, purification exosomes. We briefly exosome isolation techniques. explore great-length exosomes mechanism for substances, chemicals, chemotherapeutic drugs. also talk about benefits drawbacks This concludes with discussion future perspective challenges. hope that will provide us better understanding current state nanomedicine applications biomedicine.

Language: Английский

Citations

58
Recent insights into the nutritional immunomodulation of cancer‐related microRNAs DOI Creative Commons
Teslime Özge Şahin, Birsen Yılmaz, Neslihan Yeşilyurt

et al.

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(10), P. 4375 - 4397

Published: July 11, 2023

Abstract Cancer is the most common cause of death worldwide, following cardiovascular diseases. a multifactorial disease and many reasons such as physical, chemical, biological, lifestyle‐related factors. Nutrition, which one various factors that play role in prevention, development, treatment types cancer, affects immune system, characterized by disproportionate pro‐inflammatory signaling cancer. Studies investigating molecular mechanisms this effect have shown foods rich bioactive compounds, green tea, olive oil, turmeric, soybean significant positively changing expression miRNAs involved regulation genes associated with oncogenic/tumor‐suppressing pathways. In addition to these foods, some diet models may change specific cancer‐related different ways. While Mediterranean has been anticancer effects, high‐fat diet, methyl‐restricted are considered negative effects. This review aims discuss effects called “immune foods,” models, components on cancer prevention

Language: Английский

Citations

58
Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human disease and therapeutic modalities DOI Creative Commons
Zhijie Xu, Yuzhen Xu, Kui Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: March 29, 2023

Abstract Background The past few years have witnessed a significant increase in research related to plant-derived extracellular vesicles (PDEVs) biological and medical applications. Using biochemical technologies, multiple independent groups demonstrated the important roles of PDEVs as potential mediators involved cell-cell communication exchange bio-information between species. Recently, several contents been well identified PDEVs, including nucleic acids, proteins, lipids, other active substances. These cargoes carried by could be transferred into recipient cells remarkably influence their behaviors associated with human diseases, such cancers inflammatory diseases. Main body abstract This review summarizes latest updates regarding focuses on its role nanomedicine applications, drug delivery strategies develop diagnostic therapeutic agents for clinical management especially like cancers. Conclusion Considering unique advantages, high stability, intrinsic bioactivity easy absorption, further elaboration molecular mechanisms factors driving function will provide new horizons treatment disease.

Language: Английский

Citations

46
Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery DOI Creative Commons
Arzu Zeynep Karabay, Jaleh Barar, Yalda Hekmatshoar

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 394 - 394

Published: March 10, 2025

Most eukaryotic and prokaryotic cells have the potential to secrete a group of structures/membrane-bound organelles, collectively referred as extracellular vesicles (EVs), which offer several advantages producer/receiver cells. This review provides an overview EVs from plant sources with emphasis on their health-promoting possible use therapeutic agents. highlights essential biological effects plant-derived vesicles, including immune modulation, anticancer activities, protection against chemical toxicity pathogens, well anti-aging, anti-melanogenesis, anti-arthritic effects, along ongoing clinical studies. Evidence revealed that EVs’ contents exert beneficial properties through regulating important signaling pathways by transferring miRNAs other components. Taken all together, data proposed can be utilized nutritional compounds agents, such drug carriers. However, this emerging research area requires further in vitro/in vivo studies trials determine exact underlying mechanisms positive health treating various diseases.

Language: Английский

Citations

2
Application of plant-derived exosome-like nanoparticles in drug delivery DOI

Mohadeseh Barzin,

Amir Mohammad Bagheri, Mandana Ohadi

et al.

Pharmaceutical Development and Technology, Journal Year: 2023, Volume and Issue: 28(5), P. 383 - 402

Published: April 22, 2023

AbstractExosomes are one type of extracellular vesicles with size ranging from 30 to 150 nm, which involved in intercellular communication by transporting specific proteins, nucleic acids, and low molecular weight metabolites. The competence exosomes transfer biological materials recipient cells have made them suitable for biomedical use. Therefore, been studied as drug delivery systems various diseases due immunogenicity, preferred tumor homing, innate acquired targetability, stability. They secreted almost all multivesicular endosomes retrieved body fluids including bile, saliva, blood, lymph, urine, cerebrospinal fluid, milk, etc. Plants’ organs also secrete (Plant-derived exosome-like nanoparticles (PELNs)) considered an economical affordable source production. PELNs pharmacologically rich active molecules because owning unique compositional morphological features they can be used natural nano-carrier exogenous molecules. In this review, the bio-component applications neural disorders, tumor-targeted delivery, gene reviewed different plants such aloe, turmeric, ginger, lemon, grapefruit, grape, strawberry.Keywords: Biomedical applicationexosomesplant-derived nanoparticlesdrug AcknowledgmentsThis article is result a research project approved Student Research Committee Kerman University Medical Sciences No. 402000042, was carried out financial support Vice Chancellor Technology UniversityDisclosure statementNo potential conflict interest reported author(s).Additional informationFundingThe author(s) there no funding associated work featured article.

Language: Английский

Citations

33
Plant-Derived Extracellular Vesicles: A New Revolutionization of Modern Healthy Diets and Biomedical Applications DOI
Kai-Jiun Lo, Mu‐Hui Wang, Chi‐Tang Ho

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(6), P. 2853 - 2878

Published: Feb. 1, 2024

Plant-derived extracellular vesicles (PDEVs) have recently emerged as a promising area of research due to their potential health benefits and biomedical applications. Produced by various plant species, these EVs contain diverse bioactive molecules, including proteins, lipids, nucleic acids. Increasing in vitro vivo studies shown that PDEVs inherent pharmacological activities affect cellular processes, exerting anti-inflammatory, antioxidant, anticancer activities, which can potentially contribute disease therapy improve human health. Additionally, efficient biocompatible drug delivery vehicles treating diseases. However, while serve rising star modern healthy diets applications, further is needed address underlying knowledge gaps, especially the lack standardized protocols for isolation, identification, large-scale production. Furthermore, safety efficacy clinical applications must be thoroughly evaluated. In this review, we concisely discuss current PDEV field, characteristics, isolation methods, provide an overview state research. Finally, challenges regarding prospective issues PDEVs. This review expected new insights into vegetables fruits, inspiring advances natural food-based science technology.

Language: Английский

Citations

16
The Advances and Applications of Characterization Technique for Exosomes: From Dynamic Light Scattering to Super-Resolution Imaging Technology DOI Creative Commons
Shijia Wu,

Yalan Zhao,

Zitong Zhang

et al.

Photonics, Journal Year: 2024, Volume and Issue: 11(2), P. 101 - 101

Published: Jan. 23, 2024

Exosomes distributed by extracellular vesicles carry various information highly consistent with cells, becoming a new type of biomarker for tumor screening. However, although conventional characterization technologies can quantify size and morphology exosomes, they are limited in related fields such as function tracing, protein quantification at unit point, microstructural information. In this paper, firstly, different exosome methods systematically reviewed, dynamic light scattering, nanoparticle tracking analysis, flow cytometry, electron microscope, emerging super-resolution imaging technologies. Then, advances applications described one one. Last but not least, we compare the features exosomes propose that technology only take into account advantages techniques also provide accurate, real-time, quantitative analysis exosomes. It provides fine guide exosome-related biomedical research, well application liquid biopsy techniques.

Language: Английский

Citations

13
The Role of Cannabidiol in Liver Disease: A Systemic Review DOI Open Access
Si Chen, Jeon-Kyung Kim

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2370 - 2370

Published: Feb. 17, 2024

Cannabidiol (CBD), a non-psychoactive phytocannabinoid abundant in Cannabis sativa, has gained considerable attention for its anti-inflammatory, antioxidant, analgesic, and neuroprotective properties. It exhibits the potential to prevent or slow progression of various diseases, ranging from malignant tumors viral infections neurodegenerative disorders ischemic diseases. Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty (NAFLD), alcoholic disease, hepatitis stand prominent causes morbidity mortality chronic diseases globally. The literature substantiated CBD’s therapeutic effects across diverse vivo vitro models. However, precise mechanism action remains elusive, an absence evidence hinders translation into clinical practice. This comprehensive review emphasizes wealth data linking CBD Importantly, we delve detailed discussion receptors through which might exert effects, including cannabinoid receptors, CB1 CB2, peroxisome proliferator-activated (PPARs), G protein-coupled receptor 55 (GPR55), transient channels (TRPs), their intricate connections with In conclusion, address new questions that warrant further investigation this evolving field.

Language: Английский

Citations

11
Phytosomes: a critical tool for delivery of herbal drugs for cancer DOI
Kajal Chaudhary,

Anjali Rajora

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: April 4, 2024

Language: Английский

Citations

10