Centella asiatica and its caffeoylquinic acid and triterpene constituents increase dendritic arborization of mouse primary hippocampal neurons and improve age-related locomotion deficits in Drosophila DOI Creative Commons

Karon Rowe,

Nora E. Gray, Jonathan A. Zweig

et al.

Frontiers in Aging, Journal Year: 2024, Volume and Issue: 5

Published: July 11, 2024

Introduction Centella asiatica (CA) is known in Ayurvedic medicine as a rejuvenating herb with particular benefits the nervous system. Two groups of specialized metabolites found CA and purported to contribute its beneficial effects are triterpenes (TTs) caffeoylquinic acids (CQAs). In order evaluate role interactions TTs CQAs CA, we examined neurotrophic water extract (CAW) combinations TT CQA components mouse primary hippocampal neurons vitro Drosophila melanogaster flies vivo . Methods Primary were isolated from embryos exposed for 5 days CAW (50 μg/mL), mixtures TTs, or + 4 8 individual compounds CAW. Dendritic arborization was evaluated using Sholl analysis. aged 28 treated 2 weeks (10 mg/mL) food, compounds. tested at concentrations matching their levels treatment used. After treatment, 42 phototaxis responses. Results neurons, mix, all most significantly increased dendritic greater than control levels. However, combination decreased arborization. Drosophila, marked age-related decline fast response observed both males females over 60 period. resilience this afforded male female by onwards mg/mL), equivalent mixed mix. Of compounds, only 1,5-diCQA slowed flies. Discussion This study confirmed ability increase neuronal arborization, provide neurological The these but do not have synergistic effect. While concentrations, model, able slow down phototaxis. suggests that (or potentially higher concentrations) other needed model.

Language: Английский

Production of secondary metabolites using tissue culture-based biotechnological applications DOI Creative Commons
İbrahim İlker Özyiğit, İlhan Doğan, Aslı Hocaoğlu-Özyiğit

et al.

Frontiers in Plant Science, Journal Year: 2023, Volume and Issue: 14

Published: June 29, 2023

Plants are the sources of many bioactive secondary metabolites which present in plant organs including leaves, stems, roots, and flowers. Although they provide advantages to plants cases, not necessary for metabolisms related growth, development, reproduction. They specific species precursor substances, can be modified generations various compounds different species. Secondary used industries, dye, food processing cosmetic agricultural control as well being pharmaceutical raw materials by humans. For this reason, demand is high; therefore, needed obtained large volumes productions achieved using biotechnological methods addition production, done with classical methods. this, biotechnology put action through The most important these include tissue culture gene transfer. genetically agriculturally more productive commercially effective valuable tools industrial medical purposes therapeutic importance. With applications, also first step obtaining transgenic having desirable characteristics, it possible produce large-scale whole or tissues laboratory conditions. Currently, studies going on subject, some them receiving attention found taken place promising applications. In work, particularly benefits metabolites, their culture-based applications discussed literature presence current studies.

Language: Английский

Citations

108
A novel framework for uncovering the coordinative spectrum-effect correlation of the effective components of Yangyin Tongnao granules on cerebral ischemia-reperfusion injury in rats DOI
Junjie Chen, Qianqian Chen, Peng Xiao

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118844 - 118844

Published: Sept. 19, 2024

Language: Английский

Citations

16
Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) DOI Open Access
Marius Mioc, Andreea Milan, Daniel Malița

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(14), P. 7740 - 7740

Published: July 13, 2022

Triterpenic acids are phytocompounds with a widespread range of biological activities that have been the subject numerous in vitro and vivo studies. However, their underlying mechanisms action various pathologies not completely elucidated. The current review aims to summarize most recent literature, published last five years, regarding mechanism three triterpenic (asiatic acid, oleanolic ursolic acid), corelated different such as anticancer, anti-inflammatory, antidiabetic, cardioprotective, neuroprotective, hepatoprotective, antimicrobial. All discussed compounds share several action, targeted modulation PI3K/AKT, Nrf2, NF-kB, EMT, JAK/STAT3 signaling pathways, while other proved only be specific for part discussed, Notch, Hippo, MALAT1/miR-206/PTGS1 pathway, were highlighted well. This paper stands first our literature study on topic, which will followed by second focusing therapeutic value.

Language: Английский

Citations

43
Flavonoids and saponins: What have we got or missed? DOI Creative Commons
Xuanbin Wang, Yan Ma, Qihe Xu

et al.

Phytomedicine, Journal Year: 2022, Volume and Issue: 109, P. 154580 - 154580

Published: Dec. 5, 2022

Flavonoids and saponins are important bioactive compounds that have attracted wide research interests. This review aims to summarise the state of art pharmacology, toxicology clinical efficacy these compounds.Data were retrieved from PubMed, Cochrane Library, Web Science, Proquest, CNKI, Chongqing VIP, Wanfang, NPASS HIT 2.0 databases. Meta-analysis systematic reviews evaluated following PRISMA guideline. Statistical analyses conducted using SPSS23.0.Rising trends on flavonoids observed since 1990s 2000s, respectively. Studies pharmacological targets activities represent an area advances over past decade, resources been documented in open-access specialised databases can be with ease. The rising attributed, at least part, their links some highly investigated fields research, e.g., oxidative stress, inflammation cancer; i.e., 6.88% 3.03% publications stress cited by PubMed 1990 - 2021 involved saponins, respectively, significantly higher than percentage involving alkaloids (1.88%). effects concern chronic venous insufficiency, cervical lesions, diabetes, rhinitis, dermatopathy, prostatitis, menopausal symptoms, angina pectoris, male pattern hair loss, lymphocytic leukaemia, gastrointestinal diseases traumatic cerebral infarction, etc, while those may impact oedema deep vein incompetence, erectile dysfunction, acute injuries systemic lupus erythematosus, etc. volume vitro appears way vivo studies, only 10 meta-analyses (involving 290 interventional observational studies), 36 studies saponins. Data sorely needed pharmacokinetics, pan-assay interferences, purity tested compounds, interactions complex herbal extracts, real anti-oxidative strategies, mid- long-term toxicities. To fill gaps, further investigations warranted. On other hand, drug cause adverse but might also useful for synergism, goals enhancing or detoxifying. Furthermore, between phytochemicals intestinal microbiota worth investigating as field present a promising potential novel development.

Language: Английский

Citations

38
Biosynthesis and the Transcriptional Regulation of Terpenoids in Tea Plants (Camellia sinensis) DOI Open Access

Junchi Wei,

Yun Yang, Peng Ye

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 6937 - 6937

Published: April 8, 2023

Terpenes, especially volatile terpenes, are important components of tea aroma due to their unique scents. They also widely used in the cosmetic and medical industries. In addition, terpene emission can be induced by herbivory, wounding, light, low temperature, other stress conditions, leading plant defense responses plant–plant interactions. The transcriptional levels core genes (including HMGR, DXS, TPS) involved terpenoid biosynthesis up- or downregulated MYB, MYC, NAC, ERF, WRKY, bHLH transcription factors. These regulators bind corresponding cis-elements promoter regions genes, some them interact with factors form a complex. Recently, several key synthesis have been isolated functionally identified from plants. this work, we focus on research progress regulation terpenes plants (Camellia sinensis) thoroughly detail compounds, biosynthesis-related biosynthesis, importance. Furthermore, review potential strategies studying specific functions candidate that discriminated date.

Language: Английский

Citations

37
Saponins derived from Gynostemma pentaphyllum regulate triglyceride and cholesterol metabolism and the mechanisms: A review DOI
Peng Xie,

Hao-Tian Luo,

Wenjing Pei

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117186 - 117186

Published: Sept. 16, 2023

Language: Английский

Citations

28
Natural product-derived ferroptosis mediators DOI
Yili Chen,

Lin-An Xiong,

Lie‐Feng Ma

et al.

Phytochemistry, Journal Year: 2024, Volume and Issue: 219, P. 114002 - 114002

Published: Jan. 27, 2024

Language: Английский

Citations

12
Saponins of Selected Triterpenoids as Potential Therapeutic Agents: A Review DOI Creative Commons
Uladzimir Bildziukevich,

Martina Wimmerová,

Zdeněk Wimmer

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(3), P. 386 - 386

Published: March 2, 2023

Saponins represent important natural derivatives of plant triterpenoids that are secondary metabolites. Saponins, also named glycoconjugates, available both as and synthetic products. This review is focused on saponins the oleanane, ursane, lupane types include several displaying various pharmacological effects. Additional convenient structural modifications naturally-occurring products often result in enhancing effects parent structures. an objective for all semisynthetic reviewed products, it included this paper well. The period covered by (2019–2022) relatively short, mainly due to existence previously published papers recent years.

Language: Английский

Citations

20
Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease DOI Creative Commons

Mingzhenlong Deng,

Wanli Yan, Zhicheng Gu

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1486 - 1486

Published: Feb. 3, 2023

Alzheimer’s disease (AD) is an age-related chronic progressive neurodegenerative disease, which the main cause of dementia in elderly. Much evidence shows that onset and late symptoms AD are caused by multiple factors. Among them, aging factor pathogenesis AD, most important risk for neuroinflammation. So far, there no cure but relationship between neuroinflammation may provide a new strategy treatment AD. We herein discussed etiology hypothesis role as well anti-inflammatory natural products with potential to prevent alleviate symptoms, including alkaloids, steroids, terpenoids, flavonoids polyphenols, available great development anti-AD drugs.

Language: Английский

Citations

17
Systematic Review of Chemical Compounds with Immunomodulatory Action Isolated from African Medicinal Plants DOI Creative Commons
Wendwaoga Arsène Nikiema, Moussa Ouédraogo,

Windbedma Prisca Ouédraogo

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 2010 - 2010

Published: April 26, 2024

A robust, well-functioning immune system is the cornerstone of good health. Various factors may influence system’s effectiveness, potentially leading to failure. This review aims provide an overview structure and action immunomodulators isolated from African medicinal plants. The research was conducted according PRISMA guidelines. Full-text access articles published in English up December 2023, including plant characteristics, phytochemicals, immuno-modulatory activities, were screened. chemical structures compounds generated using ChemDraw® (version 12.0.1076), convergent distinctive signaling pathways highlighted. These phytochemicals with demonstrated immunostimulatory activity include alkaloids (berberine, piperine, magnoflorine), polysaccharides (pectin, glucan, acemannan, CALB-4, GMP90-1), glycosides (syringin, cordifolioside, tinocordiside, aucubin), phenolic (ferulic acid, vanillic eupalitin), flavonoids (curcumin, centaurein, kaempferin, luteolin, guajaverin, etc.), terpenoids (oleanolic ursolic betulinic boswellic acids, corosolic nimbidin, andrographolides). discussed exert their effects through various mechanisms, targeting modulation MAPKs, PI3K-Akt, NF-kB. mechanisms can support traditional use plants treat immune-related diseases. outcomes this are provoke structural optimization, orient on particular natural chemicals for managing inflammatory, infectious diseases cancers, or boost vaccine immunogenicity.

Language: Английский

Citations

5