Rhenium Sulfide Nanoparticles as a Biosafe Spectral CT Contrast Agent for Gastrointestinal Tract Imaging and Tumor Theranostics in Vivo DOI
Xiaoyi Wang, Jiaojiao Wang, Jinbin Pan

et al.

ACS Applied Materials & Interfaces, Journal Year: 2019, Volume and Issue: 11(37), P. 33650 - 33658

Published: Aug. 26, 2019

Spectral computed tomography (CT) imaging as a novel technique shows promising prospects in the accurate diagnosis of various diseases. However, clinically iodinated contrast agents suffer from poor signal-to-noise ratio, and emerging heavy-metal-based CT arouse great biosafety concern. Herein, we show fabrication rhenium sulfide (ReS2) nanoparticles, clinic radiotherapy sensitizer, biosafe spectral agent for gastrointestinal tract tumor theranostics vivo by teaching old drugs new tricks. The ReS2 nanoparticles were fabricated one-pot facile method at room temperature, exhibited sub-10 nm size, favorable monodispersity, admirable aqueous solubility, strong X-ray attenuation capability. More importantly, proposed possess an outstanding ability undoubted therapeutic agent. Besides, appealing photothermal performance due to their intense near-infrared absorption. nano-agent not only guarantees obvious enhancement vivo, but also allows effective imaging-guided therapy. "teaching tricks" strategy shortens time cuts cost required clinical application nano-agents based on existing toxicology testing trial results, lays down low-cost, time-saving, energy-saving development multifunctional toward applications.

Language: Английский

Efficient and Stable Solar Hydrogen Generation of Hydrophilic Rhenium-Disulfide-Based Photocatalysts via Chemically Controlled Charge Transfer Paths DOI
Jianmin Yu, Sohyeon Seo, Yongguang Luo

et al.

ACS Nano, Journal Year: 2020, Volume and Issue: 14(2), P. 1715 - 1726

Published: Jan. 28, 2020

Effective charge separation and rapid transport of photogenerated carriers without self-oxidation in transition metal dichalcogenide photocatalysts are required for highly efficient stable hydrogen generation. Here, we report that a molecular junction as an electron transfer path toward two-dimensional rhenium disulfide (2D ReS2) nanosheets from zero-dimensional titanium dioxide (0D TiO2) nanoparticles induces high efficiency stability solar generation by balanced carriers. The junctions created through the chemical bonds between functionalized ReS2 (e.g., -COOH groups) -OH groups two-phase TiO2 (i.e., ReS2-C6H5C(═O)-O-TiO2 denoted ReS2-BzO-TiO2). This enhances energy at conduction band minimum ReS2-BzO-TiO2, leading to efficiently improved reduction. Through (a Z-scheme path) recombination charges photocatalyst restrained, resulting photocatalytic activity (9.5 mmol h-1 per gram nanosheets, 4750-fold enhancement compared bulk with cycling more than 20 h. Our results provide effective TMDs preventing self-oxidation, increases durability rate

Language: Английский

Citations

61
Artificial Engineered Natural Killer Cells Combined with Antiheat Endurance as a Powerful Strategy for Enhancing Photothermal‐Immunotherapy Efficiency of Solid Tumors DOI
Da Zhang, Youshi Zheng,

Ziguo Lin

et al.

Small, Journal Year: 2019, Volume and Issue: 15(42)

Published: Aug. 29, 2019

Although photothermal therapy (PTT) is preclinically applied in solid tumor treatment, incomplete removal of PTT and heat endurance cells induces significant relapse after therefore lowering the therapeutic efficiency PTT. Herein, a programmable strategy that integrates agents (PTAs), DNAzymes, artificial engineered natural killer (A-NK) for immunotherapy hepatocellular carcinoma (HCC) designed. The novel PTAs, termed as Mn-CONASHs, with 2D structure are synthesized by coordination tetrahydroxyanthraquinone Mn2+ ions. By further adsorbing polyetherimide/DNAzymes on surface, DNAzymes@Mn-CONASHs exhibit excellent light-to-heat conversion ability, microenvironment enhanced T1 -MRI guiding antiheat ability. Furthermore, NK HCC specific targeting TLS11a-aptamer decoration constructed specifically eliminating any possible residual PTT, to systematically enhance efficacy avoid relapse. Taken together, potential A-NK combined powerful immuno-enhancing tumors highlighted, current might provide promising prospects cancer therapy.

Language: Английский

Citations

60
PEGylated rhenium nanoclusters: a degradable metal photothermal nanoagent for cancer therapy DOI Creative Commons
Zhaohua Miao, Sheng Chen, Cheng‐Yan Xu

et al.

Chemical Science, Journal Year: 2019, Volume and Issue: 10(21), P. 5435 - 5443

Published: Jan. 1, 2019

PEGylated rhenium nanoclusters were developed as a degradable and renal-clearable metallic photothermal nanoagent for CT imaging tumor therapy.

Language: Английский

Citations

59
Recent advances on TMDCs for medical diagnosis DOI
Si Meng, Yuyan Zhang, Huide Wang

et al.

Biomaterials, Journal Year: 2020, Volume and Issue: 269, P. 120471 - 120471

Published: Oct. 27, 2020

Language: Английский

Citations

58
Rhenium Sulfide Nanoparticles as a Biosafe Spectral CT Contrast Agent for Gastrointestinal Tract Imaging and Tumor Theranostics in Vivo DOI
Xiaoyi Wang, Jiaojiao Wang, Jinbin Pan

et al.

ACS Applied Materials & Interfaces, Journal Year: 2019, Volume and Issue: 11(37), P. 33650 - 33658

Published: Aug. 26, 2019

Spectral computed tomography (CT) imaging as a novel technique shows promising prospects in the accurate diagnosis of various diseases. However, clinically iodinated contrast agents suffer from poor signal-to-noise ratio, and emerging heavy-metal-based CT arouse great biosafety concern. Herein, we show fabrication rhenium sulfide (ReS2) nanoparticles, clinic radiotherapy sensitizer, biosafe spectral agent for gastrointestinal tract tumor theranostics vivo by teaching old drugs new tricks. The ReS2 nanoparticles were fabricated one-pot facile method at room temperature, exhibited sub-10 nm size, favorable monodispersity, admirable aqueous solubility, strong X-ray attenuation capability. More importantly, proposed possess an outstanding ability undoubted therapeutic agent. Besides, appealing photothermal performance due to their intense near-infrared absorption. nano-agent not only guarantees obvious enhancement vivo, but also allows effective imaging-guided therapy. "teaching tricks" strategy shortens time cuts cost required clinical application nano-agents based on existing toxicology testing trial results, lays down low-cost, time-saving, energy-saving development multifunctional toward applications.

Language: Английский

Citations

55