Journal of Materials Chemistry B,
Journal Year:
2021,
Volume and Issue:
9(9), P. 2285 - 2294
Published: Jan. 1, 2021
A
facile
and
green
method
was
developed
to
fabricate
Nd-DTPA
on
a
large
scale
without
byproducts
for
CT/spectral
CT
NIR
II
fluorescence
imaging
of
the
gastrointestinal
tract
in
vivo.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2020,
Volume and Issue:
12(6)
Published: May 22, 2020
Abstract
X‐ray
imaging
is
the
most
widely
used
diagnostic
method
in
modern
medicine
and
several
advanced
forms
of
this
technology
have
recently
emerged.
Iodinated
molecules
barium
sulfate
suspensions
are
clinically
approved
contrast
agents
used.
However,
these
existing
provide
limited
information,
suboptimal
for
new
techniques
developing
safety
concerns.
Thus,
over
past
15
years,
there
has
been
a
rapid
growth
development
nanoparticles
as
agents.
Nanoparticles
desirable
features
such
high
payloads,
potential
long
circulation
times,
tunable
physicochemical
properties.
also
range
biomedical
applications
disease
treatment,
targeted
imaging,
cell
tracking.
In
review,
we
discuss
principles
behind
generation
introduce
types
modalities,
well
elements
chemical
compositions
that
suitable
novel
agent
development.
We
focus
on
progress
nanoparticle
developed
to
be
renally
clearable,
circulating,
theranostic,
targeted,
or
feature
conjunction
with
newly
multi‐energy
computed
tomography
mammographic
technologies.
Finally,
offer
perspectives
current
limitations
emerging
research
topics
expectations
future
field.
This
article
categorized
under:
Diagnostic
Tools
>
vivo
Nanodiagnostics
Imaging
Nanotechnology
Approaches
Biology
Nanoscale
Systems
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: March 18, 2022
Ultrasounds
are
often
used
in
cancer
treatment
protocols,
e.g.
to
collect
tumor
tissues
the
right
location
using
ultrasound-guided
biopsy,
image
region
of
more
affordable
and
easier
use
apparatus
than
MRI
CT,
or
ablate
HIFU.
The
efficacy
these
methods
can
be
further
improved
by
combining
them
with
various
nano-systems,
thus
enabling:
(i)
a
better
resolution
ultrasound
imaging,
allowing
for
example
visualization
angiogenic
blood
vessels,
(ii)
specific
targeting
anti-tumor
chemotherapeutic
drugs
gases
attached
encapsulated
nano-systems
released
controlled
manner
under
application,
(iii)
at
site
moderate
heating
temperatures
Furthermore,
some
display
adjustable
sizes,
i.e.
nanobubbles
grow
into
micro-bubbles.
Such
dual
size
is
advantageous
since
it
enables
gathering
within
same
unit
properties
nano
bubbles
via
EPR
effect
enhanced
contrasting
micro
bubbles.
Interestingly,
way
which
act
against
could
principle
also
adjusted
accurately
selecting
nano-system
among
large
choice
tuning
values
parameters,
lead,
due
their
mechanical
nature,
effects
such
as
cavitation
that
usually
not
observed
purely
electromagnetic
waves
potentially
help
destroying
tumor.
This
review
highlights
clinical
potential
combined
treatments
improve
benefit/risk
ratio
current
treatments.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(6), P. 2733 - 2733
Published: March 17, 2023
Rhenium
(Re)
is
widely
used
in
the
diagnosis
and
treatment
of
cancer
due
to
its
unique
physical
chemical
properties.
Re
has
more
valence
electrons
outer
shell,
allowing
it
exist
a
variety
oxidation
states
form
different
geometric
configurations
with
many
ligands.
The
luminescence
properties,
lipophilicity,
cytotoxicity
complexes
can
be
adjusted
by
changing
ligand
Re.
This
article
mainly
reviews
development
radionuclide
188Re
radiotherapy
some
innovative
applications
as
well
therapeutic
approaches
imaging
techniques
therapy.
In
addition,
current
application
future
challenges
opportunities
are
also
discussed.
Science Progress,
Journal Year:
2024,
Volume and Issue:
107(1)
Published: Jan. 1, 2024
X-ray
computed
tomography
(CT)
and
magnetic
resonance
(MR)
imaging
are
essential
tools
in
modern
medical
diagnosis
treatment.
However,
traditional
contrast
agents
inadequate
the
of
various
health
conditions.
Consequently,
development
targeted
nano-contrast
has
become
a
crucial
area
focus
image-enhancing
agents.
To
fully
understand
current
agents,
this
review
provides
an
overview
preparation
methods
research
advancements
CT
MR
CT/MR
multimodal
described
previous
publications.
Due
to
physicochemical
properties
nanomaterials,
such
as
self-assembly
surface
modifiability,
these
specific
can
greatly
improve
targeting
lesions
through
clearly
highlight
distinction
between
normal
tissues
both
MR.
As
result,
they
have
potential
be
used
early
stages
disease
diagnostic
capacity
level
imaging.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 4143 - 4170
Published: July 1, 2023
Abstract:
The
diagnosis
of
gastrointestinal
(GI)
diseases
currently
relies
primarily
on
invasive
procedures
like
digestive
endoscopy.
However,
these
can
cause
discomfort,
respiratory
issues,
and
bacterial
infections
in
patients,
both
during
after
the
examination.
In
recent
years,
nanomedicine
has
emerged
as
a
promising
field,
providing
significant
advancements
diagnostic
techniques.
Nanoprobes,
particular,
offer
distinct
advantages,
such
high
specificity
sensitivity
detecting
GI
diseases.
Integration
nanoprobes
with
advanced
imaging
techniques,
nuclear
magnetic
resonance,
optical
fluorescence
imaging,
tomography,
correlation
significantly
enhanced
detection
capabilities
for
tumors
inflammatory
bowel
disease
(IBD).
This
synergy
enables
early
precise
staging
disorders.
Among
nanoparticles
investigated
clinical
applications,
superparamagnetic
iron
oxide,
quantum
dots,
single
carbon
nanotubes,
nanocages
have
extensively
studied
utilized
agents.
review
aimed
to
provide
insights
into
potential
applications
modern
specific
focus
their
role
facilitating
range
disorders,
including
IBD
colorectal
cancer
(CRC).
Additionally,
we
discussed
challenges
associated
implementation
nanotechnology-based
diagnostics
explored
future
prospects
translation
this
field.
Keywords:
nano-diagnostics,
gastroenterology,
tumor,
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(5), P. 3337 - 3345
Published: May 3, 2024
A
stimuli-responsive
drug
delivery
nanocarrier
with
a
core–shell
structure
combining
photothermal
therapy
and
chemotherapy
for
killing
cancer
cells
was
constructed
in
this
study.
The
multifunctional
ReS2@mSiO2-RhB
entails
an
ReS2
hierarchical
nanosphere
coated
fluorescent
mesoporous
silica
shell.
three-dimensional
nanostructure
is
capable
of
effectively
absorbing
near-infrared
(NIR)
light
converting
it
into
heat.
These
nanospheres
were
generated
by
hydrothermal
synthesis
process
leading
to
the
self-assembly
few-layered
nanosheets.
shell
further
on
surface
through
surfactant-templating
sol–gel
approach
provide
accessible
mesopores
uploading.
dye
(Rhodamine
B)
covalently
attached
precursors
incorporated
during
walls
toward
conferring
imaging
capability
nanocarrier.
Doxorubicin
(DOX),
known
drug,
used
proof-of-concept
study
assess
material's
ability
function
as
carrier.
While
pores
are
not
capped,
molecule
loading
release
take
advantage
pH-governed
electrostatic
interactions
between
wall.
enabled
content
high
19.83
mg/g
doxorubicin.
ReS2@mSiO2-RhB-DOX
nanocarrier's
cumulative
rate
at
pH
values
that
simulate
physiological
conditions
showed
significant
responsiveness,
reaching
59.8%
6.8
98.5%
5.5.
vitro
testing
using
HeLa
cervical
proved
has
strong
eradication
upon
irradiation
NIR
laser
owing
combined
effect.
results
highlight
potential
nanoparticles
future.
Journal of Nanobiotechnology,
Journal Year:
2021,
Volume and Issue:
19(1)
Published: March 31, 2021
Abstract
Metal
sulfide
nanomaterials
(MeSNs)
are
a
novel
class
of
metal-containing
composed
metal
ions
and
sulfur
compounds.
During
the
past
decade,
scientists
found
that
MeSNs
engineered
by
specific
approaches
not
only
had
high
biocompatibility
but
also
exhibited
unique
physicochemical
properties
for
cancer
therapy,
such
as
Fenton
catalysis,
light
conversion,
radiation
enhancement,
immune
activation.
To
clarify
development
promote
clinical
transformation
MeSNs,
first
section
this
paper
describes
appropriate
fabrication
medical
science
analyzes
features
limitations
each
approach.
Secondly,
we
sort
out
mechanisms
functional
in
including
drug
delivery,
phototherapy,
radiotherapy,
chemodynamic
gas
immunotherapy.
It
is
worth
noting
intact
degradation
products
can
exert
different
types
anti-tumor
activities.
Thus,
usually
exhibit
synergistic
antitumor
properties.
Finally,
future
expectations
challenges
research
translational
medicine
spotlighted.
Nanoscale Horizons,
Journal Year:
2022,
Volume and Issue:
7(5), P. 533 - 542
Published: Jan. 1, 2022
Gastrointestinal
(GI)
tract
is
one
of
the
hard-to-reach
target
tissues
for
delivery
contrast
agents
and
drugs
mediated
by
nanoparticles
due
to
its
harsh
environment.
Herein,
we
overcame
this
barrier
designing
orally
ingestible
probiotic
vectors
'hitchhiking'
ultrasmall
hafnia
(HfO2)
(∼1-2
nm)
nanoparticles.
The
minute-made
synthesis
these
accomplished
through
a
simple
reduction
reaction.
These
were
incubated
with
bacteria
potential
health
benefits
non-specifically
taken
up
their
small
size.
Subsequently,
lyophilized
packed
into
capsule
be
administered
as
radiopaque
delineating
GI
features.
nano-bio-hybrid
entities
could
successfully
utilized
in
vivo
conventional
multispectral
computed
tomography
(CT).
We
demonstrated
'color'
accumulated
using
advanced
detectors
photon
counting
CT.
enhanced
nano-bio-interfacing
capability
achieved
here
can
circumvent
traditional
nanoparticle
solubility
problems
while
offering
patient
friendly
approach
imaging
replace
currently
practiced
barium
meal.
