Recent advances in selective photothermal therapy of tumor

Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)

Published: Oct. 24, 2021

Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways improve the efficiency of tumor ablation treat cancer, PTT may cause severe damage normal tissue due systemic distribution photothermal agents (PTAs) body and inaccurate laser exposure during To further survival rate patients reduce possible side effects on other parts body, it is still necessary explore PTAs with high selectivity precise In this review, we summarized strategies treatment PTT, such as increasing accumulation at sites endowing self-regulating conversion function. The views challenges selective were discussed, especially prospects their clinical applications.

Language: Английский

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Manganese‐Based Tumor Immunotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(19)

Published: Sept. 19, 2022

Abstract As an essential micronutrient, manganese (Mn) participates in various physiological processes and plays important roles host immune system, hematopoiesis, endocrine function, oxidative stress regulation. Mn‐based nanoparticles are considered to be biocompatible show versatile applications nanomedicine, particular utilized tumor immunotherapy the following ways: 1) acting as a nanocarrier deliver immunotherapeutic agents for immunotherapy; 2) serving adjuvant regulate microenvironment enhance 3) activating host's system through cGAS‐STING pathway trigger 4) real‐time monitoring effect by magnetic resonance imaging (MRI) since Mn 2+ ions ideal MRI contrast agent which can significantly T 1 ‐weighted signal after binding proteins. This comprehensive review focuses on most recent progress of nanoplatforms immunotherapy. The characteristics first discussed guide design multifunctional nanoplatforms. Then biomedical nanoplatforms, including alone, immunotherapy‐involved multimodal synergistic therapy, imaging‐guided detail. Finally, challenges future developments highlighted.

Language: Английский

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Recent Advances in Engineered Materials for Immunotherapy‐Involved Combination Cancer Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(31)

Published: May 28, 2021

Abstract Immunotherapy that can activate immunity or enhance the immunogenicity of tumors has emerged as one most effective methods for cancer therapy. Nevertheless, single‐mode immunotherapy is still confronted with several critical challenges, such low immune response, tumor infiltration, and complex immunosuppression microenvironment. Recently, combination other therapeutic modalities a powerful strategy to augment outcome in fighting against cancer. In this review, recent research advances chemotherapy, phototherapy, radiotherapy, sonodynamic therapy, metabolic microwave thermotherapy are summarized. Critical challenges future direction immunotherapy‐based also discussed.

Language: Английский

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Reversing cold tumors to hot: An immunoadjuvant-functionalized metal-organic framework for multimodal imaging-guided synergistic photo-immunotherapy

Bioactive Materials, Journal Year: 2020, Volume and Issue: 6(2), P. 312 - 325

Published: Aug. 29, 2020

Immunotherapy assays using immunoadjuvants and tumor antigens could greatly increase the survival rates of patients with malignant tumors. As effective carriers, metal-organic frameworks (MOFs) have been widely utilized in cancer therapy due to their remarkable histocompatibility low toxicity. Herein, we constructed a multimodal imaging-guided synergistic photoimmunotherapy by employing specific MOF (MIL101-NH2) as core carrier; was dual-dressed photoacoustic fluorescent signal donors (indocyanine green, ICG) immune adjuvants (cytosine-phosphate-guanine sequence, CpG) named [email protected] This nanocarrier passively target site through EPR effect achieve imaging (fluorescence, photoacoustic, photothermal magnetic resonance imaging) tumor. Synergistic achieved via simultaneous photodynamic methods 808 nm laser irradiation. GSH-controlled release immunoadjuvant into microenvironment. Furthermore, released tumor-associated antigen along CpG induce transformation cells from cold hot activating system, which significantly enhanced cytotoxicity high cure minimal side-effects. strategy utilizing provides promising approach for diagnosis treatment cancer.

Language: Английский

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Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking Aptamers for Enhanced Adoptive Immunotherapy in Solid Tumors

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(29), P. 12022 - 12028

Published: April 4, 2020

Abstract Herein, we propose an aptamer‐equipping strategy to generate specific, universal and permeable (SUPER) NK cells for enhanced immunotherapy in solid tumors. were chemically equipped with TLS11a aptamer targeting HepG2 PDL1‐specific without genetic alteration. The dual aptamer‐equipped exhibited high specificity tumor cells, resulting higher cytokine secretion apoptosis/necrosis compared parental or single cells. Interestingly, induced remarkable upregulation of PDL1 expression enhancing checkpoint blockade. Furthermore, vivo intravital imaging demonstrated infiltration into deep region, leading therapeutic efficacy This work offers a straightforward chemical equip aptamers, holding considerable potential adoptive

Language: Английский

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Review of Functionalized Nanomaterials for Photothermal Therapy of Cancers

ACS Applied Nano Materials, Journal Year: 2021, Volume and Issue: 4(11), P. 11353 - 11385

Published: Nov. 16, 2021

Photothermal therapy (PTT) is recognized as a promising approach for cancer theranostics via the nonradiative conversion of light into heat energy. PTT treatment able to reduce adverse side effects traditional chemotherapy. Some nanomaterials functionalized with unique physical and chemical properties have been integrated multiple imaging modalities therapeutic function applications. In past decade, various applications reviewed, but comprehensive survey all classes photothermal developed in recent years has not done. A discussion mechanisms using different their application combination useful providing insights material development disease future. this review, advancement excellence combined therapies field anticancer are discussed. The momentous property tailored advancing noninvasive also highlighted. Because great deal decades reviewed years, we only include latest results reported 5 comparison.

Language: Английский

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Therapeutic DNAzymes: From Structure Design to Clinical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(30)

Published: Feb. 5, 2023

Therapeutic DNAzymes have unceasingly intrigued the scientific community owing to their prosperous gene regulation capability. The efficacy of against many types diseases has been extensively studied for over two decades. However, high expectations are still not translated clinic because low effectiveness in vivo. Over last five years, several aspects considered optimize DNAzyme-integrated therapeutics, including structural stability, mechanism exploration, cell internalization rate, cofactor activation, and off-target effects. Hence, this review first discusses early monotherapy design DNAzymes. Subsequently, latest modes action reviewed, followed by an elaboration on stabilization strategies considering catalytic core substrate-binding arms. DNAzyme-based synergistic therapy is then examined, highlighting responsive carrier construction, effects, discovered advanced functions, concerns. Beyond this, key clinical advances elucidated showcasing progress. Finally, future trends development challenges DNAzyme-powered therapeutics coming years discussed detail.

Language: Английский

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Tumor microenvironment-responsive manganese-based nanomaterials for cancer treatment

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 480, P. 215027 - 215027

Published: Jan. 16, 2023

Language: Английский

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NK cell-based tumor immunotherapy

Bioactive Materials, Journal Year: 2023, Volume and Issue: 31, P. 63 - 86

Published: Aug. 9, 2023

Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-infected tumor cells. They are particularly powerful for elimination of hematological cancers, have attracted considerable interests therapy solid tumors. However, the treatment tumors with NK less effective, which can be attributed very complicated immunosuppressive microenvironment that may lead inactivation, insufficient expansion, short life, poor infiltration Fortunately, development advanced nanotechnology has provided potential solutions these issues, could improve immunotherapy efficacy In this review, we summarize activation inhibition mechanisms in tumors, recent advances cell-based boosted by diverse nanomaterials. We also propose challenges opportunities clinical application immunotherapy.

Language: Английский

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Exploring the revolutionary potential of MXene nanoparticles in breast Cancer therapy: A review of applications and future prospects

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114411 - 114411

Published: March 15, 2025

Language: Английский

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