Bioorganic Chemistry, Journal Year: 2023, Volume and Issue: 132, P. 106349 - 106349
Published: Jan. 8, 2023
Language: Английский
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(24)
Published: April 26, 2023
Photodynamic therapy (PDT), with its advantages of high targeting, minimally invasive, and low toxicity side effects, has been widely used in the clinical various tumors, especially superficial tumors. However, tumor microenvironment (TME) presents hypoxia due to oxygen (O2 ) supply caused by abnormal vascularization neoplastic tissues O2 consumption induced rapid proliferation cells. The efficacy oxygen-consumping PDT can be hampered a hypoxic TME. To address this problem, researchers have developing advanced nanoplatforms strategies enhance therapeutic effect treatment. This review summarizes recent against TME, thus enhancing efficacy, including increasing content TME through delivering tumors situ generations ; decreasing during design type I photosensitizers. Moreover, synergistically combined other methods such as chemotherapy, photothermal therapy, immunotherapy, gas is accounted for addressing challenging problems mono environments, resistance, proliferation, metastasis. Finally, perspectives opportunities challenges future research translations are provided.
Language: Английский
Citations
88
RSC Advances, Journal Year: 2023, Volume and Issue: 13(21), P. 14443 - 14460
Published: Jan. 1, 2023
This review summarizes the common inorganic and organic photothermal nanoagents their applications in tumor therapy. Additionally, challenges future prospects of nanomaterial-based therapy cancer treatment are discussed.
Language: Английский
Citations
77
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(29)
Published: June 9, 2023
Abstract Growing concern about photothermal tumor therapy (PTT) as a promising alternative to conventional liver cancer treatment, which is treatment strategy that utilizes near‐infrared (NIR) light‐induced agents (PTAs) yield effects localize thermal damage for tumors. Herein, given the gap between experimental research and clinical application, this review seeks timely summarize highlight recent progress of PTAs used in vivo vitro last five‐year. The implications various on multifunctional conversion capability, structure‐performance correlations PTT, together with evaluation their potential application are systematically dissected further dig out what buried mechanism is. Besides, higher requirements put forward discrepancies crucial issues faced by different PTT related medical technical obstacles being conquered, lays solid theoretical foundation field oncology whole, especially cancer. Finally, it expected can present valuable guidance design efficient, photostability, biosafety‐aware anticancer while stepping into fast traffic lane from bench bedside foreseeable future.
Language: Английский
Citations
56
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 310, P. 120721 - 120721
Published: Feb. 20, 2023
Language: Английский
Citations
49
Nanotheranostics, Journal Year: 2024, Volume and Issue: 8(2), P. 219 - 238
Published: Jan. 1, 2024
In 2020, approximately 10 million deaths worldwide were attributed to cancer, making it the primary cause of death globally.Photothermal therapy (PTT) is one novel ways treat and abolish cancer.PTT significantly impacts cancer theranostics compared other therapies like surgery, chemotherapy, radiotherapy due its remarkable binding capability tumor sites lower invasiveness into normal healthy tissues.PTT relies on photothermal agents (PTAs), which generate heat by absorbing near-infrared (NIR) light destroying cells.Several PTT remain longer in reticuloendothelial system (RES) induce toxicity, restricting their use biomedical field.To overcome this problem, usage biodegradable nano-photothermal required.This review has discussed mechanism action different types bio-nanomaterials used for PTT.We also focussed combinatorial effects with effect human health.The role LED lights mild hypothermia been briefly review.
Language: Английский
Citations
17
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Photodynamic therapy (PDT) and photothermal (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, enhanced reproducibility. Nonetheless, how further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies performance PDT PTT by optimizing structural design SCOPAs. These encompass augmenting reactive oxygen species (ROS) generation, mitigating dependence, elevating light absorption capacity, broadening region, enhancing conversion efficiency (PCE). Additionally, this also underscores ideal for developing with balanced PTT. Furthermore, synergies are highlighted between other modalities such ferroptosis, gas therapy, chemotherapy, immunotherapy. By providing comprehensive analysis these strategies, aspires serve valuable resource clinicians researchers, facilitating wider application advancement SCOPAs‐mediated
Language: Английский
Citations
3
ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 10904 - 10917
Published: July 7, 2022
Semimetallic nanomaterials as photothermal agents for bioimaging and cancer therapy have attracted tremendous interest. However, the poor stability, low biocompatibility, single component limit their therapeutic efficiency in treatment. Here, manganese-doped VSe2 semimetallic nanosheets were prepared subsequently modified with chitosan (named VSe2/Mn-CS NSs) combined enzyme catalytic therapy. NSs show high property a conversion of 34.61% upon 808 nm near-infrared laser irradiation. In tumor microenvironment, can convert endogenous H2O2 into lethal hydroxyl radicals (•OH) to induce cell apoptosis. The interaction between glutathione (GSH) Se–Se bonds results depletion GSH level, valence states transition manganese ions is also beneficial consumption. This dual markedly enhances peroxidase (POD) activity, leading •OH production improved effect. What more, T1-weighted magnetic resonance photoacoustic imaging endow ability guide track treatment process. Our study provides research strategy application diagnosis
Language: Английский
Citations
46
Materials, Journal Year: 2022, Volume and Issue: 15(4), P. 1606 - 1606
Published: Feb. 21, 2022
Cancer remains one of the leading causes death in world. For a number neoplasms, efficiency conventional chemo- and radiation therapies is insufficient because drug resistance marked toxicity. Plasmonic photothermal therapy (PPT) using local hyperthermia induced by gold nanoparticles (AuNPs) has recently been extensively explored tumor treatment. However, despite attractive promises, current PPT status limited laboratory experiments, academic papers, only few preclinical studies. Unfortunately, most nanoformulations still share similar fate: great promises fair trials. This review discusses challenges prospects plasmonic nanomedicine based on photodynamic (PDT). We start with consideration fundamental principles underlying properties AuNPs to tune their plasmon resonance for desired NIR-I, NIR-2, SWIR optical windows. The basic simulation cross-sections heating under CW pulsed irradiation are discussed. Then, we consider state-of-the-art methods wet chemical synthesis popular PPPT such as silica/gold nanoshells, Au nanostars, nanorods, nanocages. efficiencies these compared, applications shortly In separate section, discuss fabrication other laser ablation liquid method. second part devoted our recent experimental results laser-activated interaction healthy tissues achievements research groups this application area. unresolved issues significant accumulation organs mononuclear phagocyte system, causing potential toxic effects nanoparticles, possibility recurrence due presence survived cells. prospective ways solving problems discussed, including developing combined antitumor PDT. conclusion summarize urgent needs PPT-based nanomedicine.
Language: Английский
Citations
45
Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 166, P. 42 - 68
Published: May 29, 2023
Language: Английский
Citations
38
ACS Nano, Journal Year: 2023, Volume and Issue: 17(20), P. 20218 - 20236
Published: Oct. 15, 2023
Low-temperature photothermal therapy (PTT) is a noninvasive method that harnesses the effect at low temperatures to selectively eliminate tumor cells, while safeguarding normal tissues, minimizing thermal damage, and enhancing treatment safety. First we evaluated transcriptome of cells gene level following low-temperature observed significant enrichment genes involved in cell cycle heat response-related signaling pathways. To address this challenge, have developed an engineering multifunctional nanoplatform offered all-in-one strategy for efficient sensitization PTT. Specifically, utilized MoS2 nanoparticles as core generate temperature (40–48 °C). The was coated with DPA load CPT-11 Fe2+ further modified PEG iRGD enhance specificity (MoS2/Fe@CPT-11-PEG-iRGD). Laser- acid-triggered release can significantly increase intracellular H2O2 content, cooperate ions lipid ROS activate ferroptosis. Furthermore, induced arrest temperature-sensitive S-phase, increased levels contributed degradation HSPs protein expression. This synergistic approach could effectively induce death by sensitized PTT combination ferroptosis chemotherapy. Our also maximize eradication prolong survival time tumor-bearing mice vivo. will provide more possibilities clinical applications potential avenues development multiple treatments.
Language: Английский
Citations
36