The Progress and Prospect of Zeolitic Imidazolate Frameworks in Cancer Therapy, Antibacterial Activity, and Biomineralization

Advanced Healthcare Materials, Journal Year: 2020, Volume and Issue: 9(12)

Published: May 7, 2020

Abstract The progressive development of zeolitic imidazolate frameworks (ZIFs), as a subfamily metal‐organic (MOFs), and their unique features, including tunable pore size, large surface area, high thermal stability, biodegradability/biocompatibility, have made them attractive in the field biomedicine, especially for drug delivery biomineralization applications. porosity ZIFs gives opportunity encapsulating amount therapeutic drugs, proteins, imaging cargos, or combination to construct advanced multifunctional systems (DDSs) with combined capabilities. This review summarizes recent strategies on design fabrication ZIF‐based nansystems exploration biomedical field. First, developments adjustment particle functionality, morphology are discussed, which important achieving optimized therapeutic/theranostic nanosystems. Second, trends application ZIF nanocarriers loading diverse anticancer medicines, antibiotic enzymes, photosensitizers, well photothermal agents, investigated order understand how DDSs can be designed based nanoparticles treat different diseases, such cancer infection. Finally, prospects future research direction applications nanomedicines discussed.

Language: Английский

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Therapeutic strategies against bacterial biofilms

Fundamental Research, Journal Year: 2021, Volume and Issue: 1(2), P. 193 - 212

Published: Feb. 21, 2021

The emergence of multi-drug resistance makes bacterial infection a major threat to public health and economy. formation biofilms is one the main reasons resistance. complexity chemical composition physical structure elimination mature difficult problem. highly antibiotic resistant property urgently calls for potent antimicrobial agents novel antibiofilm strategies. Researchers have made lot efforts in this field. Here we review current strategies eliminate progress related drug delivery nanosystems, with aim inspiring researchers design new systems.

Language: Английский

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Metal organic frameworks for antibacterial applications

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 435, P. 134975 - 134975

Published: Feb. 2, 2022

Language: Английский

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Organic Photo-antimicrobials: Principles, Molecule Design, and Applications

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(43), P. 17891 - 17909

Published: Oct. 22, 2021

The emergence of multi-drug-resistant pathogens threatens the healthcare systems world-wide. Recent advances in phototherapy (PT) approaches mediated by photo-antimicrobials (PAMs) provide new opportunities for current serious antibiotic resistance. During PT treatment, reactive oxygen species or heat produced PAMs would react with cell membrane, consequently leaking cytoplasm components and effectively eradicating different like bacteria, fungi, viruses, even parasites. This Perspective will concentrate on development organic (OPAMs) their application as practical therapeutic agents into therapy local infections, wound dressings, removal biofilms from medical devices. We also discuss how to design highly efficient OPAMs modifying chemical structure conjugating a targeting component. Moreover, this provides discussion general challenges direction what further needs be done. It is hoped that through overview, can prosper more widely used microbial infections future, especially at time when global COVID-19 epidemic getting serious.

Language: Английский

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Green metal-organic frameworks (MOFs) for biomedical applications

Microporous and Mesoporous Materials, Journal Year: 2022, Volume and Issue: 335, P. 111670 - 111670

Published: Jan. 3, 2022

Language: Английский

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Continuous Self‐Oxygenated Double‐Layered Hydrogel under Natural Light for Real‐Time Infection Monitoring, Enhanced Photodynamic Therapy, and Hypoxia Relief in Refractory Diabetic Wounds Healing

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(32)

Published: May 31, 2022

Abstract The human health is still threatened by refractory keratitis and diabetic foot ulcers caused bacterial infections, hypoxia, chronic inflammation, so that patients are exposed to the risk of amputation, vision loss, even death. Herein, an oxygen‐producing double‐layered hydrogel developed can visualize infections supply oxygen enhance antimicrobial photodynamic therapy (PDT) inflammation alleviation for wounds healing. inner layer (containing oxidized sodium alginate/carboxymethyl chitosan [CMCS] via Schiff‐base) incorporated with a metal–organic framework (PCN‐224) pH indicator (bromothymol blue). outer agarose CMCS) loads photosynthetic cyanobacteria continuously generate relieve hypoxia tissue PDT efficiency. Meanwhile, some unique advantages reflected continuous under natural light, such as cell migration acceleration, relief, promotion skin capillary formation, wound recovery. Therefore, self‐oxygenated offers tremendous benefits in synergistic treatment anaerobe from timely infection monitoring repair.

Language: Английский

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Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(6), P. 3209 - 3209

Published: March 16, 2022

Antimicrobial photodynamic therapy and allied antimicrobial chemotherapy have shown remarkable activity against bacterial pathogens in both planktonic biofilm forms. There has been little or no resistance development therapy. Furthermore, recent developments therapies that involve combination with photothermal hyperthermia therapy, magnetic antibiotic cold atmospheric pressure plasma additive synergistic enhancement of its efficacy. This paper reviews applications non-invasive often used it, including sonodynamic nanozyme enhanced The antibiofilm mechanisms are discussed. review proposes these technologies a great potential to overcome the associated formation.

Language: Английский

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Self-powered enzyme-linked microneedle patch for scar-prevention healing of diabetic wounds

Science Advances, Journal Year: 2023, Volume and Issue: 9(28)

Published: July 14, 2023

Diabetic wounds with complex pathological features and a difficult-to-heal nature remain formidable challenge. To address this challenge, we design fabricate self-powered enzyme-linked microneedle (MN) patch composed of anode cathode MN arrays, which respectively contain glucose oxidase (GOx) horseradish peroxidase (HRP) encapsulated in ZIF-8 nanoparticles. The enzymatic cascade reaction the can effectively reduce local hyperglycemia diabetic while generating stable microcurrents to promote rapid healing wounds. Therefore, treated exhibit rapid, complete, scar-preventative healing, be attributed synergistic actions hypoglycemic, antibacterial, anti-inflammatory, bioelectrical stimulation. In brief, is an effective method rapidly wound prevent scar formation.

Language: Английский

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Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 13966 - 14037

Published: Nov. 22, 2023

Phosphorescence, characterized by luminescent lifetimes significantly longer than that of biological autofluorescence under ambient environment, is great value for biomedical applications. Academic evidence fluorescence imaging indicates virtually all metrics (sensitivity, resolution, and penetration depths) are improved when progressing into wavelength regions, especially the recently reported second near-infrared (NIR-II, 1000–1700 nm) window. Although emission probes does matter, it not clear whether guideline "the wavelength, better effect" still suitable developing phosphorescent probes. For tissue-specific bioimaging, long-lived probes, even if they emit visible phosphorescence, enable accurate visualization large deep tissues. studies dealing with bioimaging tiny architectures or dynamic physiopathological activities, prerequisite rigorous planning long-wavelength being aware cooperative contribution long wavelengths improving spatiotemporal depth, sensitivity bioimaging. In this Review, emerging molecular engineering methods room-temperature phosphorescence discussed through lens photophysical mechanisms. We highlight roles from to NIR-II windows toward bioapplications. To appreciate such advances, challenges prospects in rapidly growing described.

Language: Английский

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Tunable Zeolitic Imidazolate Framework‐8 Nanoparticles for Biomedical Applications

Small Methods, Journal Year: 2023, Volume and Issue: 8(3)

Published: Nov. 23, 2023

Abstract Zeolite imidazole framework‐8 (ZIF‐8) is the most prestigious one among zeolitic imidazolate framework (ZIF) with tunable dimensions and unique morphological features. Utilizing its synthetic adjustability structural regularity, ZIF‐8 exhibits enhanced flexibility, allowing for a wide range of functionalities, such as loading nanoparticle components while preserving biomolecules activity. Extensive efforts are made from investigating synthesis techniques to develop novel applications over decades. In this review, development recent progress various approaches briefly summarized. addition, interesting properties adjustable porosity, excellent thermal, chemical stabilities introduced. Further, five representative biomedical highlighted based on above physicochemical properties. Finally, remaining challenges offered insights into future outlook also discussed. This review aims understand co‐relationships between structures offering opportunity construct attractive materials promising characteristics.

Language: Английский

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