Nanoplatforms Based on Covalent Organic Frameworks (COFs) for Biomedical Applications

Chemistry of Materials, Journal Year: 2023, Volume and Issue: 35(20), P. 8353 - 8370

Published: Oct. 12, 2023

Covalent organic frameworks (COFs) make up an emerging class of crystalline porous materials mainly composed light elements in the form dynamic covalent bonds. Owing to their two- or three-dimensional network structures and ideal properties, including low density, large specific surface area, high chemical stability, good biocompatibility, COFs have shown a wide range applications optoelectronic devices, energy conversion storage, adsorption separation, sensing, catalysis, biomedicine. This review provides overview recent advances functional COF-based nanoplatforms for biological diagnosis treatment, such as enzyme protein drug delivery, photodynamic/photothermal therapy, synergistic treatment. Challenges future directions developing biomedicine related are also discussed. We envisage that this will inspire scientists, chemists, biologists, clinical doctors working fields work closely move field toward trials human healthcare.

Language: Английский

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Lactate Efflux Inhibition by Syrosingopine/LOD Co‐Loaded Nanozyme for Synergetic Self‐Replenishing Catalytic Cancer Therapy and Immune Microenvironment Remodeling

Advanced Science, Journal Year: 2023, Volume and Issue: 10(26)

Published: June 29, 2023

An effective systemic mechanism regulates tumor development and progression; thus, a rational design in one-stone-two-birds strategy is meant for cancer treatment. Herein, hollow Fe

Language: Английский

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Nanozyme-enhanced ferroptosis for cancer treatment

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 8(7), P. 1685 - 1702

Published: Jan. 1, 2024

Nanozymes could mimic the catalytic activity of natural enzymes, then stimulate Fenton reaction for reactive oxygen species overproduction and lipid peroxidation, ultimately induce ferroptosis to exert anticancer effects.

Language: Английский

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A tumor‐targeting nano‐adjuvant for in situ vaccine based on ultrasound therapy

Aggregate, Journal Year: 2024, Volume and Issue: 5(3)

Published: Jan. 15, 2024

Abstract Ultrasound‐generated antigens combined with TLR7/8 agonists as adjuvants have demonstrated significant anti‐tumor efficacy an in‐situ vaccine. However, the use of can cause severe inflammatory responses. In this study, we present a novel tumor‐targeting nano‐adjuvant termed aPDL1‐PLG/R848 NPs, which are composed aPDL1 antibody, Fc‐III‐4C peptide linker (Fc‐linker) and poly( L ‐glutamic acid)‐ grafted ‐R848. Under ultrasound irradiation, antigen‐presenting cells activate immune mechanisms in vivo under dual stimulation situ adjuvants. The strategy inhibits primary tumor growth induces strong antigen‐specific memory effect to prevent recurrence vivo. This work offers safe potent platform for cancer vaccine based on therapy.

Language: Английский

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Nanoparticle-Mediated Synergistic Chemoimmunotherapy for Cancer Treatment

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4533 - 4568

Published: May 1, 2024

Until now, there has been a lack of effective strategies for cancer treatment. Immunotherapy high potential in treating several cancers but its efficacy is limited as monotherapy. Chemoimmunotherapy (CIT) holds promise to be widely used Therefore, identifying their involvement and synergy CIT approaches decisive. Nano-based drug delivery systems (NDDSs) are ideal because they can simultaneously target immune cells cells, promoting accumulation, reducing the toxicity drug. In this review, we first introduce five current immunotherapies, including checkpoint blocking (ICB), adoptive cell transfer therapy (ACT), vaccines, oncolytic virus (OVT) cytokine therapy. Subsequently, immunomodulatory effects chemotherapy by inducing immunogenic death (ICD), tumor killer infiltration, down-regulating immunosuppressive inhibiting checkpoints have described. Finally, NDDSs-mediated collaborative introduced detail, development nanoparticles prospected.

Language: Английский

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Toxic reactive oxygen species enhanced chemodynamic therapy by copper metal-nanocellulose based nanocatalysts

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 289, P. 119432 - 119432

Published: March 31, 2022

Language: Английский

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Tumor Metabolism-Rewriting Nanomedicines for Cancer Immunotherapy

ACS Central Science, Journal Year: 2023, Volume and Issue: 9(10), P. 1864 - 1893

Published: Sept. 22, 2023

Cancer immunotherapy has become an established therapeutic paradigm in oncologic therapy, but its efficacy remains unsatisfactory the majority of cancer patients. Accumulating evidence demonstrates that metabolically hostile tumor microenvironment (TME), characterized by acidity, deprivation oxygen and nutrients, accumulation immunosuppressive metabolites, promotes dysfunction tumor-infiltrating immune cells (TIICs) thereby compromises effectiveness immunotherapy. This indicates potential role metabolic intervention reinvigoration antitumor immunity. With merits multiple drug codelivery, cell organelle-specific targeting, controlled release, multimodal metabolism-rewriting nanomedicines have recently emerged as attractive strategy to strengthen responses. review summarizes current progress development multifunctional for evoking A special focus is placed on how these reinvigorate innate or adaptive immunity regulating glucose metabolism, amino acid lipid nucleotide metabolism at site. Finally, prospects challenges this emerging field are discussed.

Language: Английский

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A Mitochondria‐Targeted NIR‐II AIEgen Induced Pyroptosis for Enhanced Tumor Immunotherapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(29)

Published: June 7, 2023

Abstract Cancer immunotherapy is a favorable strategy for facilitating anti‐tumor immunity, but it shows limited benefits in clinical practice owing to the immunosuppressive tumor microenvironment. Pyroptosis great immunostimulatory effect on tumor, whereas lack of pyroptotic inducer with imaging property has restricted its progress theranostics. Herein, mitochondria‐targeted aggregation‐induced emission (AIE) luminogen (TPA‐2TIN) NIR‐II designed highly efficient induction cell pyroptosis. The fabricated TPA‐2TIN nanoparticles can be efficiently taken up by cells and selectively accumulated long term observed fluorescence imaging. More importantly, effectively stimulate immune responses both vitro vivo mediated mitochondrial dysfunctions subsequent activation pathway. Ultimately, reversal microenvironment significantly enhances checkpoint therapy. This study paves new avenue adjuvant cancer.

Language: Английский

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Inorganic Nanoparticle Functionalization Strategies in Immunotherapeutic Applications

Biomaterials Research, Journal Year: 2024, Volume and Issue: 28

Published: Jan. 1, 2024

Language: Английский

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A carrier-free photodynamic nanodrug to enable regulation of dendritic cells for boosting cancer immunotherapy

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 147, P. 366 - 376

Published: May 16, 2022

Language: Английский

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