This
study
presents
the
use
of
nanoscale
covalent
organic
frameworks
(nCOFs)
conjugated
with
tumor-targeting
peptides
for
targeted
therapy
triple-negative
breast
cancer
(TNBC).
While
have
previously
been
used
delivery,
their
conjugation
COFs
represents
an
innovative
approach
in
this
field.
In
particular,
we
developed
alkyne-functionalized
nCOFs
chemically
modified
cyclic
RGD
(Alkyn-nCOF-cRGD).
configuration
is
designed
to
specifically
target
α
Accounts of Chemical Research,
Journal Year:
2024,
Volume and Issue:
57(8), P. 1174 - 1187
Published: April 1, 2024
ConspectusSupramolecular
coordination
complexes
(SCCs)
are
predictable
and
size-tunable
supramolecular
self-assemblies
constructed
through
directional
bonds
between
readily
available
organic
ligands
metallic
receptors.
Based
on
planar
3D
structures,
SCCs
can
be
mainly
divided
into
two
categories:
metallacycles
(e.g.,
rhomboidal,
triangular,
rectangular,
hexagonal)
metallacages
tetrahedral,
hexahedral,
dodecahedral).
The
enable
the
efficient
formation
of
with
well-defined
architectures
geometries.
exhibit
several
advantages,
including
good
directionality,
strong
interaction
force,
tunable
modularity,
solution
processability,
making
them
highly
attractive
for
biomedical
applications,
especially
in
cellular
imaging
cancer
therapy.
Compared
their
molecular
precursors,
demonstrate
enhanced
uptake
a
strengthened
tumor
accumulation
effect,
owing
to
inherently
charged
structures.
These
properties
chemotherapeutic
potential
inherent
platinum
have
promoted
widespread
application
antitumor
Furthermore,
defined
structures
SCCs,
achieved
via
design
modification
assembly
elements
introduction
different
functional
groups,
combat
malignant
tumors
multipronged
treatment
modalities.
Because
development
cancer-treatment
methodologies
integrated
clinics
has
evolved
from
single-modality
chemotherapy
synergistic
multimodal
therapy,
therapy
is
crucial.
While
some
pioneering
reviews
explored
bioapplications
often
categorized
by
specific
function
or
focusing
metal
ligand
types,
comprehensive
exploration
multifunctionality
critical
gap
current
literature.In
this
Account,
we
focus
platinum-based
applications
other
metals,
such
as
Pd-,
Rh-,
Ru-,
Ir-based
been
Therrien
Casini
et
al.,
garnered
significant
interest,
unique
advantages
which
enhance
efficacy,
considered
prominent
candidates
therapies
desirable
properties,
potent
activity,
exceptionally
low
systemic
toxicity,
active
tumor-targeting
ability,
uptake.
diverse
diagnostic
therapeutic
modalities
chemotherapy,
photothermal
photodynamic
therapy)
single
platform
based
Consequently,
herein,
summarize
our
recent
research
particular
emphasis
cooperative
interplay
methods.
In
Conclusions
section,
present
key
advancements
basis
findings
propose
future
directions
that
may
significantly
impact
field.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(9), P. 10451 - 10465
Published: April 25, 2024
The
continuous
rise
in
atmospheric
CO2
concentration,
overconsumption
of
energy
resources,
and
release
extraordinary
organic
pollutants
are
challenging
issues
the
modern
era.
Catalytic
technology
offers
a
promising
solution
to
tackle
these
environmental
challenges
parallel
by
facilitating
highly
effective
sustainable
processes.
Herein,
we
report
fabrication
series
different
nature
polyarylimide
(PAI)-based
covalent–organic
frameworks
(COFs)
via
polycondensation
reaction
altering
linkers,
solvents,
other
experimental
conditions.
To
optimize
their
catalytic
performance,
resultant
PAI-COFs
were
further
decorated
with
metal–organic
(ZIF-67).
decoration
COF4
ZIF-67
led
adjusted
bandgaps,
created
an
active
site,
enhanced
charge
separation
migration
photoexcited
electron–hole
(e–h)
pairs,
extended
light
absorption
visible
region,
also
facilitated
transferring
electrons
between
COFs
MOFs
photoelectron
modulation
approach.
Based
on
our
findings,
it
is
confirmed
that
(MOFs)
optimal
catalysts
compared
(COF1,
COF2,
COF3)
(ZIF-8).
Interestingly,
pristine
COF4,
5ZIF-67/COF4
nanohybrid
revealed
∼8-fold
∼5.3-fold
for
conversion,
direct
capturing,
photoelectrochemical
conversion
faradaic
efficiency
50%.
Likewise,
as-fabricated
catalyst
exhibits
exceptional
activities
photocatalytic
hydrogen
production
pollutant
oxidation.
Ultimately,
this
work
will
provide
roadmap
design
COF-based
nanohybrids
applications.
Chemistry of Materials,
Journal Year:
2024,
Volume and Issue:
36(5), P. 2177 - 2193
Published: March 1, 2024
Bacterial
infection,
the
cause
of
many
diseases,
has
become
one
most
severe
global
public
health
threats.
The
emergence
antimicrobial
resistance
poses
a
significant
challenge
in
treating
bacterial
infections.
Recently,
synthetic
macrocycles
with
various
well-defined
cavities
and
excellent
dynamic,
reversible,
directional
noncovalent
interactions
can
not
only
form
complexation
biomarkers
or
drugs
via
host–guest
recognition
but
also
enable
controlled
drug
delivery
response
to
external
stimuli,
such
as
pH,
thermal,
redox,
competitive
binding,
light
irradiation.
Therefore,
macrocycle-based
functional
materials
have
received
increasing
attention
promising
candidates
for
precise
on-demand
bacteria
inhibition.
This
Perspective
provides
an
overview
recent
progress
design
synthesis
antibacterial
properties.
mechanisms
applications
are
discussed
detail.
Finally,
existing
challenges
future
opportunities
this
emerging
research
field
put
forward
hope
promoting
further
development
toward
superior
biomedical
applications.
Materials Horizons,
Journal Year:
2024,
Volume and Issue:
11(9), P. 2077 - 2094
Published: Jan. 1, 2024
Fluorescent
covalent
organic
frameworks
(COFs)
are
promising
candidates
for
imaging
living
cells
due
to
their
unique
properties.
Herein,
we
critically
reviewed
the
progress
and
structure–activity
relations
of
COFs
effective
bioimaging.
Cell Reports Physical Science,
Journal Year:
2024,
Volume and Issue:
5(3), P. 101845 - 101845
Published: Feb. 26, 2024
Covalent
organic
frameworks
(COFs)
have
emerged
as
an
important
material
for
antimicrobial
applications
due
to
their
customizable
porous
structures,
abundant
active
sites,
and
good
stability.
In
this
perspective,
we
explore
the
topological
connectivity
in
construction
of
currently
developed
COFs,
which
mainly
include
–B–O–,
–N–H–,
β-ketoenamine,
azine/triazine.
The
advantages
pristine
COFs
mono-
synergistic
antimicrobials
are
integrated
discussed.
We
further
summarize
COF-embedded
hybrid
materials,
such
COFs/metal
nanoparticles,
COFs/metal-organic
frameworks,
COFs/carbon
COFs/other
demonstrate
diverse
design
application
concepts.
Finally,
outline
challenges
promising
prospects
COF
materials
biomedical
industrial
fields,
emphasizing
need
these
from
a
multidimensional
perspective.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
63(8)
Published: Nov. 21, 2023
Nanomedicines
are
extensively
used
in
cancer
therapy.
Covalent
organic
frameworks
(COFs)
crystalline
porous
materials
with
several
benefits
for
therapy,
including
porosity,
design
flexibility,
functionalizability,
and
biocompatibility.
This
review
examines
the
use
of
COFs
therapy
from
perspective
reticular
chemistry
function-oriented
design.
First,
modification
sites
functionalization
methods
discussed,
followed
by
their
potential
as
multifunctional
nanoplatforms
tumor
targeting,
imaging,
integrating
functional
components.
Finally,
some
challenges
clinical
translation
presented
hope
promoting
development
COF-based
anticancer
nanomedicines
bringing
closer
to
trials.
