Biodegradable nanomaterials for diagnosis and therapy of tumors DOI

Dongmiao Cao,

Liang Chen,

Ziwen Zhang

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(9), P. 1829 - 1848

Published: Jan. 1, 2023

Although degradable nanomaterials have been widely designed and applied for cancer bioimaging various treatments, few reviews of biodegradable reported. Herein, we summarized the representative research advances with respect to mechanism degradation their application in tumor imaging therapy. First, four kinds microenvironment (TME) responsive are presented, including pH, glutathione (GSH), hypoxia matrix metalloproteinase (MMP) degradation. Second, external stimulation is briefly. Next, outlined applications bioimaging. Finally, focused on some typical examples radiotherapy (RT), photothermal therapy (PTT), starvation therapy, photodynamic (PDT), chemotherapy, chemodynamic (CDT), sonodynamic (SDT), gene immunotherapy combination

Language: Английский

Biomimetic Nanosonosensitizers Combined with Noninvasive Ultrasound Actuation to Reverse Drug Resistance and Sonodynamic-Enhanced Chemotherapy against Orthotopic Glioblastoma DOI
Huaqing Chen, Shengping Zhang, Quan Fang

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 17(1), P. 421 - 436

Published: Dec. 27, 2022

Glioblastoma (GBM) is the most devastating brain tumor and highly resistant to conventional chemotherapy. Herein, we introduce biomimetic nanosonosensitizer systems (MDNPs) combined with noninvasive ultrasound (US) actuation for orthotopic GBM-targeted delivery sonodynamic-enhanced MDNPs were fabricated biodegradable pH-sensitive polyglutamic acid (PGA) chemotherapeutic agent sonosensitizer doxorubicin (DOX), camouflaged human GBM U87 cell membranes. presented homologous targeting accumulation in vivo long-term circulation ability. They effectively passed through blood-brain barrier (BBB) under US assistance reached site. exhibited controllable US-elicited sonodynamic effect by generation of reactive oxygen species (ROS). ROS not only induced cancer apoptosis but also downregulated drug-resistance-related factors disrupt chemoresistance increase sensitivity The study treatments further proved that US-augmented synergistic antitumor efficacy strongly prolonged survival rate mice. use low-dose DOX safety enabled repeated treatment (4 times) without obvious cardiotoxicity. This effective safe US-enhanced chemotherapy strategy advantages high drug holds great promise deep-seated drug-resistant tumors.

Language: Английский

Citations

56
Tumor Microenvironment-Adaptive Nanoplatform Synergistically Enhances Cascaded Chemodynamic Therapy DOI Creative Commons
Yuemin Wang, Duan Wang, Yuyue Zhang

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 22, P. 239 - 253

Published: Oct. 7, 2022

Chemodynamic therapy (CDT), a noninvasive strategy, has emerged as promising alternative to conventional chemotherapy for treating tumors. However, its therapeutic effect is limited by the amount of H2O2, pH value, hypoxic environment tumors, and it suboptimal tumor-targeting ability. In this study, tumor cell membrane-camouflaged mesoporous Fe3O4 nanoparticles loaded with perfluoropentane (PFP) glucose oxidase (GOx) are used microenvironment-adaptive nanoplatform ([email protected]2-G), which synergistically enhances antitumor CDT. Mesoporous selected inducers photothermal Fenton reactions nanocarriers. GOx depletes within cells starving cells, while producing H2O2 subsequent ·OH generation. Moreover, PFP, can carry O2, relieves hypoxia in provides O2 cascade reaction. Finally, camouflaged osteosarcoma membranes, endowing homologous targeting immune escape abilities. Both vivo vitro evaluations reveal high synergistic efficacy [email protected]2-G, desirable tumor-inhibition rate (90.50%), indicates great potential platform clinical cancer.

Language: Английский

Citations

54
Highly Efficient GSH-Responsive “Off–On” NIR-II Fluorescent Fenton Nanocatalyst for Multimodal Imaging-Guided Photothermal/Chemodynamic Synergistic Cancer Therapy DOI
Haimei Li, Yang Liu, Biao Huang

et al.

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(29), P. 10470 - 10478

Published: July 11, 2022

Accurate diagnosis and effective treatment of malignant tumors under the interference complex diverse tumor microenvironments (TMEs) have become focus research. Herein, an innovative TME-activated biomimetic nanocatalyst with quad-modal imaging capabilities second near-infrared (NIR-II) "turn-on" fluorescence imaging, magnetic resonance (MRI), photoacoustic (PAI), photothermal (PTI) was designed developed for self-enhanced photothermal/chemodynamic synergistic therapy. The catalyst fabricated by loading glucose oxidase (GOD) Ag2S quantum dots (QDs) on MnO2 nanosheets coating them a 4T1 cell membrane (AMG@CM), which enables to successfully escape immune clearance appealing tumor-targeting ability biocompatibility. NIR-II at 1130 nm QDs quenched could be recovered in vivo through glutathione (GSH)-induced degradation MnO2, enabling excellent TME-responsive visualization. Simultaneously, released Mn2+ can catalyze H2O2 produce abundant hydroxyl radicals (•OH), achieving synergistically enhanced chemodynamic therapy (CDT) radiation. Moreover, CDT GOD due extra produced H2O2. This work demonstrates novel highly efficient multimodal imaging-guided integrated strategy dual-enhanced precise treatment.

Language: Английский

Citations

51
Nano-ROS-generating approaches to cancer dynamic therapy: Lessons from nanoparticles DOI
Qinyi Zhang, Qiuhua Luo, Zimeng Liu

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 457, P. 141225 - 141225

Published: Dec. 29, 2022

Language: Английский

Citations

49
Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics DOI

Yifan Di,

Ruizhu Deng,

Zhu Liu

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122391 - 122391

Published: Nov. 15, 2023

Language: Английский

Citations

37
Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study DOI Creative Commons

Zhenjiang Wu,

Kunming Cheng,

Zefeng Shen

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 9, 2023

Background: Ultrasound-triggered sonodynamic therapy (SDT), as a non-invasive approach, has attracted considerable attention in wide variety of malignant tumors and other diseases. Over the past 2 decades, number scientific publications on SDT increased rapidly. However, there is still lack one comprehensive report that summarizes global research trends knowledge landscapes field detail. Thus, we performed bibliometric analysis from 2000 to 2021 track current hotspots highlight future directions. Methods: We collected Web Science Core Collection database. The annual citations, major contributors, popular journals, international collaborations, co-cited references co-occurrence keywords were analyzed visualized with CiteSpace, VOSviewer, R-bibliometrix. Results: A total 701 included. publication output 5 175 2021, average growth rate was 18.4%. China most productive country 463 documents (66.05%), Harbin Medical University prolific institution (N = 73). Ultrasound Medicine Biology published papers related SDT. Materials , Chemistry areas receiving interest. All divided into four different clusters including studies mechanisms, drug delivery nanoparticles, cancer therapy, well ultrasound sonosensitizers. In addition nanomaterials-related mesoporous silica nanosheets, liposomes, microbubble TiO nanoparticle, following directions such immunogenic cell death, metal-organic framework, photothermal hypoxia, tumor microenvironment, chemodynamic combination resistance, intensity focused ultrasound, delivery, Staphylococcus aureus also deserve further may continue explode future. Conclusion: bright treatment, nanomaterials have increasingly influenced development nano-technology. Overall, this study first attempt analyze SDT, which could provide valuable for later researchers better understand trends, frontiers domain.

Language: Английский

Citations

30
Biomimetic redox-responsive prodrug micelles with diselenide linkage for platinum nanozymes augmented sonodynamic/chemo combined therapy of colon cancer DOI

Yuanru Zhao,

Jingwen Xu, Yuanyuan Zhang

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 472, P. 144911 - 144911

Published: July 19, 2023

Language: Английский

Citations

29
A Phase Engineering Strategy of Perovskite‐Type ZnSnO3:Nd for Boosting the Sonodynamic Therapy Performance DOI
Rui Zhang,

Pengyu Zang,

Dan Yang

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(25)

Published: March 21, 2023

Abstract The sensitization performance of sonosensitizers plays a key role in the sonodynamic therapy (SDT) effect. Herein, ZnSnO 3 :Nd nanoparticles with R 3c phase/amorphous heterogeneous structure are developed by phase engineering strategy and applied as an ideal sonosensitizer. In crystalline perovskite‐type :Nd, substitution Zn 2+ Nd 3+ causes O 2p non‐bonded state to move toward Fermi level, which optimizes band for ultrasound reducing bandgap. Meanwhile, unequal charge can also form electron traps oxygen vacancies shorten migration distance, accelerates electron–hole separation inhibits carrier recombination, thus improving acoustic sensitivity. Moreover, dangling bonds exposed on surface amorphous provide more active sites, localized states may promote separation, resulting synergistic SDT particular, released from acidic tumor microenvironment (TME) reduces adenosine triphosphate production inhibiting transport chain , promotes cell apoptosis through destroying redox balance TME. Combining inherent second near infrared computed tomography imaging capabilities, this nanoplatform shows promising perspective clinic field.

Language: Английский

Citations

25
An Ultrasound‐Triggered STING Pathway Nanoagonist for Enhanced Chemotherapy‐Induced Immunogenic Cell Death DOI
Ye Tian, Hao Tian, Bei Li

et al.

Small, Journal Year: 2024, Volume and Issue: 20(26)

Published: Jan. 15, 2024

Abstract Although chemotherapy has the potential to induce tumor immunotherapy via immunogenic cell death (ICD) effects, how control intensity of immune responses still deserves further exploration. Herein, a controllable ultrasound (US)‐triggered chemo‐immunotherapy nanoagonist is successfully synthesized by utilizing pH and reactive oxygen species (ROS) dual‐responsive PEG‐polyphenol assemble sonosensitizer zinc oxide (ZnO) doxorubicin (DOX). The PZnO@DOX nanoparticles have an intelligent disassembly release DOX ions in acidic conditions. Notably, US irradiation generates ROS sonodynamic therapy accelerates drug process. Interestingly, after PZnO@DOX+US treatment, injured cells double‐stranded DNA (dsDNA) from nucleus mitochondria into cytosol. Subsequently, both dsDNA bind with cyclic GMP‐AMP synthase activate stimulator interferon genes (STING) pathway, resulting dendritic maturation, ultimately promoting DOX‐induced ICD effects antigen‐specific T immunity. Therefore, chemotherapy‐induced can be modulated non‐invasive US.

Language: Английский

Citations

12
Multivalence Manganese Mediated Dual ROS Generator for Augmented Chemodynamic Therapy and Activated Antitumor Immunogenic Responses DOI

Linlin Huo,

Shiqi Zhu,

Jie Zeng

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(3), P. 885 - 895

Published: Feb. 8, 2024

The efficacy of chemodynamic therapy (CDT) and its potential to induce immunogenic cell death (ICD) are highly dependent on the types efficiency generated reactive oxygen species (ROS). Herein, we innovatively develop a manganese platinum (MnPt) nanozyme with dual ROS generation for magnetic resonance imaging guided CDT ICD. multivalence state Mn ions authorizes MnPt simultaneously generate hydroxyl radical singlet under high H2O2 acid condition, which obviously increases ROS. Significantly, mild photothermal conversion enzyme-like activity endow regulate tumor microenvironment elevate operating rate, further increasing in vitro/vivo. Moreover, exaltation both significantly enhances immunogenicity initiates immune response limit metastases. This study provides practical strategy accurate diagnosis efficient tumors.

Language: Английский

Citations

9