Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Abstract
Owing
to
the
unpredictable
size
of
wounds
and
irregular
edges
formed
by
trauma,
nanofibers’
highly
customizable
adherent
in
situ
deposition
can
contribute
intervention
healing
process.
However,
electrospinning
is
limited
constraints
conventional
polymeric
materials
despite
its
potential
for
anti-inflammatory
antimicrobial
properties.
Here,
inspired
Janus
structure
biochemistry
nanometal
ions,
we
developed
an
sprayed
method
overcome
bacterial
infections
immune
imbalances
during
wound
healing.
The
bilayer
fiber
scaffold
has
a
hydrophobic
outer
layer
composed
polycaprolactone
(PCL)
hydrophilic
inner
gelatin,
poly(L-lactic
acid)
(PLLA),
magnesium
oxide
nanoparticles,
constituting
PCL/PLLA-gelatin-MgO
(PPGM)
electrospun
scaffold.
This
blocked
colonization
growth
bacteria
remained
stable
on
continuous
properties
promote
Furthermore,
PPGM
modulated
collagen
inflammatory
microenvironment
full-thickness
skin
model,
significantly
accelerating
vascularization
epithelialization
progression.
personalized
excellent
as
new
type
dressing
first
aid
healthcare.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: Feb. 2, 2023
Despite
all
the
efforts
made
in
tissue
engineering
for
tendon
repair,
management
of
injuries
still
poses
a
challenge,
as
current
treatments
are
unable
to
restore
function
tendons
following
injuries.
Hydrogels,
due
their
exceptional
biocompatibility
and
plasticity,
have
been
extensively
applied
regarded
promising
candidate
biomaterials
regeneration.
Varieties
approaches
designed
functionally-adapted
hydrogels
combined
with
other
factors
(e.g.,
bioactive
molecules
or
drugs)
materials
enhancement
repair.
This
review
first
summarized
state
knowledge
on
mechanisms
underlying
process
healing.
Afterward,
we
discussed
novel
strategies
fabricating
overcome
issues
frequently
encountered
during
applications
including
poor
mechanical
properties
undesirable
degradation.
In
addition,
comprehensively
rational
design
promoting
stem-cell-based
Polymers,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1566 - 1566
Published: March 21, 2023
With
the
degradation
after
aging
and
destruction
of
high-intensity
exercise,
frequency
tendon
injury
is
also
increasing,
which
will
lead
to
serious
pain
disability.
Due
structural
specificity
tissue,
traditional
treatment
repair
has
certain
limitations.
Biodegradable
polymer
electrospinning
technology
with
good
biocompatibility
degradability
can
effectively
tendons,
its
mechanical
properties
be
achieved
by
adjusting
fiber
diameter
spacing.
Here,
this
review
first
briefly
introduces
structure
function
process
injury.
Then,
different
kinds
biodegradable
natural
polymers
for
are
summarized.
advantages
disadvantages
three-dimensional
(3D)
electrospun
products
in
regeneration
summarized,
as
well
optimization
scaffolds
bioactive
materials
latest
application
engineering.
Bioactive
molecules
optimize
these
improve
their
performance.
Importantly,
we
discuss
3D
scaffold’s
superior
stages
repair.
Meanwhile,
combination
other
advanced
technologies
greater
potential
Finally,
relevant
patents
repairing
damaged
clinical
applications,
problems
current
development,
future
directions
In
general,
use
fibers
a
promising
exciting
research
field,
but
further
needed
fully
understand
tissue
Journal of Biosciences and Medicines,
Journal Year:
2024,
Volume and Issue:
12(03), P. 275 - 290
Published: Jan. 1, 2024
Regenerative
medicine
progress
is
based
on
the
development
of
cell
and
tissue
bioengineering.
One
aims
engineering
scaffolds,
which
should
substitute
functions
replaced
organ
after
their
implantation
into
body.
The
material
must
meet
a
range
requirements,
including
biocompatibility,
mechanical
strength,
elasticity.
Furthermore,
materials
have
to
be
attractive
for
growth:
stimulate
adhesion,
migration,
proliferation
differentiation.
natural
biomaterials
silk
its
component
(silk
fibroin).
An
increasing
number
scientists
in
world
are
studying
fibroin.
purpose
this
review
article
provide
information
about
properties
fibroin),
as
well
manufacture
clinical
application
each
configuration
fibroin
medicine.
Materials
research
methods.
Actual
publications
foreign
authors
resources
PubMed,
Medline,
E-library
been
analyzed.
selection
criteria
were
containing
structure
components
silk,
methods
production
nature.
This
placed
strong
emphasis
fibroin,
ways
artificial
modification
it
use
various
sphere
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Abstract
Owing
to
the
unpredictable
size
of
wounds
and
irregular
edges
formed
by
trauma,
nanofibers’
highly
customizable
adherent
in
situ
deposition
can
contribute
intervention
healing
process.
However,
electrospinning
is
limited
constraints
conventional
polymeric
materials
despite
its
potential
for
anti-inflammatory
antimicrobial
properties.
Here,
inspired
Janus
structure
biochemistry
nanometal
ions,
we
developed
an
sprayed
method
overcome
bacterial
infections
immune
imbalances
during
wound
healing.
The
bilayer
fiber
scaffold
has
a
hydrophobic
outer
layer
composed
polycaprolactone
(PCL)
hydrophilic
inner
gelatin,
poly(L-lactic
acid)
(PLLA),
magnesium
oxide
nanoparticles,
constituting
PCL/PLLA-gelatin-MgO
(PPGM)
electrospun
scaffold.
This
blocked
colonization
growth
bacteria
remained
stable
on
continuous
properties
promote
Furthermore,
PPGM
modulated
collagen
inflammatory
microenvironment
full-thickness
skin
model,
significantly
accelerating
vascularization
epithelialization
progression.
personalized
excellent
as
new
type
dressing
first
aid
healthcare.
