Layered double hydroxides for regenerative nanomedicine and tissue engineering: recent advances and future perspectives DOI Creative Commons

Junsi Luo,

Yiteng Cui,

Laijun Xu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 22, 2025

With the rapid development of nanotechnology, layered double hydroxides (LDHs) have attracted considerable attention in biomedical field due to their highly tunable composition and structure, superior biocompatibility, multifunctional bioactivity, exceptional drug delivery performance. However, a focused comprehensive review addressing role LDHs specifically tissue regeneration has been lacking. This aims fill that gap by providing systematic in-depth overview recent advances application across various regenerative domains, including bone repair, cartilage reconstruction, angiogenesis, wound healing, nerve regeneration. Beyond presenting emerging applications, places particular emphasis on elucidating underlying mechanisms through which exert therapeutic effects. Although demonstrate promise medicine, clinical translation remains its infancy. To address this, we not only provided our insights into personalized problems arise tissues, but also discussing prospecting common challenges LDHs. These include optimizing synthesis techniques, enhancing biosafety stability, improving drug-loading efficiency, designing composite materials, establishing pathways facilitate transition from laboratory research practice.

Language: Английский

Layered double hydroxide-based nanomaterials for biomedical applications DOI
Tingting Hu, Zi Gu, Gareth R. Williams

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(14), P. 6126 - 6176

Published: Jan. 1, 2022

Against the backdrop of increased public health awareness, inorganic nanomaterials have been widely explored as promising nanoagents for various kinds biomedical applications. Layered double hydroxides (LDHs), with versatile physicochemical advantages including excellent biocompatibility, pH-sensitive biodegradability, highly tunable chemical composition and structure, ease composite formation other materials, shown great promise in In this review, we comprehensively summarize recent advances LDH-based Firstly, material categories are discussed. The preparation surface modification nanomaterials, pristine LDHs, nanocomposites LDH-derived then described. Thereafter, systematically describe potential LDHs applications drug/gene delivery, bioimaging diagnosis, cancer therapy, biosensing, tissue engineering, anti-bacteria. Finally, on basis current state art, conclude insights remaining challenges future prospects rapidly emerging field.

Language: Английский

Citations

261

Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications DOI Creative Commons
Lei Li, Irem Soyhan, Eliza M. Warszawik

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(20)

Published: March 19, 2024

Abstract Layered double hydroxides (LDHs) have been widely studied for biomedical applications due to their excellent properties, such as good biocompatibility, degradability, interlayer ion exchangeability, high loading capacity, pH‐responsive release, and large specific surface area. Furthermore, the flexibility in structural composition ease of modification LDHs makes it possible develop specifically functionalized meet needs different applications. In this review, recent advances applications, which include LDH‐based drug delivery systems, cancer diagnosis therapy, tissue engineering, coatings, functional membranes, biosensors, are comprehensively discussed. From these various research fields, can be seen that there is great potential possibility use However, at same time, must recognized actual clinical translation still very limited. Therefore, current limitations related on discussed by combining limited examples with requirements biomaterials. Finally, an outlook future provided.

Language: Английский

Citations

32

Solubilization techniques used for poorly water-soluble drugs DOI Creative Commons

Bing Xie,

Yaping Liu, Xiaotong Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4683 - 4716

Published: Sept. 2, 2024

About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.

Language: Английский

Citations

19

Nanomedicine: How nanomaterials are transforming drug delivery, bio-imaging, and diagnosis DOI Creative Commons
Fatma Kurul, Hasret Turkmen, Arif E. Çetin

et al.

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 7, P. 100129 - 100129

Published: Jan. 1, 2025

Citations

18

Enhanced tumor self-targeting of lemon-derived extracellular vesicles by embedding homotypic cancer cell membranes for efficient drug delivery DOI Creative Commons
Luyao Yang, Liang Ge, Bingjie Cai

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 1, 2025

Language: Английский

Citations

2

Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering DOI Creative Commons
Vera Regina Leopoldo Constantino, Mariana Pires Figueiredo, Vagner Roberto Magri

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 413 - 413

Published: Jan. 26, 2023

The development of biomaterials has a substantial role in pharmaceutical and medical strategies for the enhancement life quality. This review work focused on versatile based nanocomposites comprising organic polymers class layered inorganic nanoparticles, aiming drug delivery (oral, transdermal, ocular delivery) tissue engineering (skin bone therapies). Layered double hydroxides (LDHs) are 2D nanomaterials that can intercalate anionic bioactive species between layers. layers hold metal cations confer intrinsic biological activity to LDHs as well biocompatibility. intercalation allows formation systems with elevated loading capacity modified release profiles promoted by ion exchange and/or solubilization. integration, antigenicity, stimulation collagen formation, among other beneficial characteristics LDH, have been observed vivo assays. association properties biocompatible LDH-drug nanohybrids produces multifunctional compatible living matter. Such stimuli-responsive, show appropriate mechanical properties, be prepared creative methods allow fine-tuning release. They processed end form films, beads, gels, monoliths etc., reach orientated therapeutic applications. Several studies attest higher performance polymer/LDH-drug nanocomposite compared hybrid or free drug.

Language: Английский

Citations

31

Biomaterials with cancer cell-specific cytotoxicity: challenges and perspectives DOI

Zhaoyou Chu,

Wanni Wang,

Zheng Wang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8847 - 8877

Published: Jan. 1, 2024

Significant advances have been made in materials for biomedical applications, including tissue engineering, bioimaging, cancer treatment,

Language: Английский

Citations

15

Nano‐bio interactions between 2D nanomaterials and mononuclear phagocyte system cells DOI Creative Commons
Jing Zhao, Zheng Chen,

Shanbiao Liu

et al.

BMEMat, Journal Year: 2024, Volume and Issue: 2(2)

Published: Jan. 10, 2024

Abstract Two‐dimensional (2D) nanomaterials, known for their unique atomic arrangements and exceptional physicochemical properties, have garnered significant attention in biomedical applications, particularly the realms of immunotherapy tissue engineering tumor therapy. These applications necessitate a thorough assessment potential influence 2D nanomaterials on immune cells. Notably, mononuclear phagocyte system (MPS) cells, which play pivotal roles both innate adaptive immunity, are essential maintaining organismal homeostasis. MPS cells with phagocytic capability contribute to prevention foreign body invasion elimination dead or senescent Furthermore, including macrophages dendritic serve as vital bridges between responses. Therefore, understanding nano‐bio interactions is imperative. cellular uptake, cytocompatibility, immunological impact invaluable purposeful design nanomaterials. Herein, we provide an overview latest advancements discuss current challenges future prospects employing field nanomedicine.

Language: Английский

Citations

13

Facile fabrication of a fungicide and plant immune inducer co-delivery nanosystem for enhanced control efficacy against plant disease DOI
Yunhao Gao, Zhiyuan Zhou, Gang Tang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 482, P. 148817 - 148817

Published: Jan. 18, 2024

Language: Английский

Citations

11

Two-dimensional nanomaterials induced nano-bio interfacial effects and biomedical applications in cancer treatment DOI Creative Commons
Yan Wang, Xiao Zhang, Hua Yue

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 18, 2024

Abstract Two-dimensional nanomaterials (2D NMs), characterized by a large number of atoms or molecules arranged in one dimension (typically thickness) while having tiny dimensions the other two dimensions, have emerged as pivotal class materials with unique properties. Their flat and sheet-like structure imparts distinctive physical, chemical, electronic attributes, which offers several advantages biomedical applications, including enhanced surface area for efficient drug loading, surface-exposed allowing precise chemical modifications, ability to form hierarchical multilayer structures synergistic functionality. Exploring their nano-bio interfacial interactions biological components holds significant importance comprehensively systematically guiding safe applications. However, current lack in-depth analysis comprehensive understanding effects on cancer treatment motivates our ongoing efforts this field. This study provides survey recent advances utilizing 2D NMs treatment. It insights into structural characteristics, synthesis methods, modifications diverse NMs. The investigation further delves formation interfaces during vivo utilization. Notably, discusses wide array applications With potential revolutionize therapeutic strategies outcomes, are poised at forefront treatment, holding promise transformative advancements. Graphical

Language: Английский

Citations

11