Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: May 22, 2025
With
the
rapid
development
of
nanotechnology,
layered
double
hydroxides
(LDHs)
have
attracted
considerable
attention
in
biomedical
field
due
to
their
highly
tunable
composition
and
structure,
superior
biocompatibility,
multifunctional
bioactivity,
exceptional
drug
delivery
performance.
However,
a
focused
comprehensive
review
addressing
role
LDHs
specifically
tissue
regeneration
has
been
lacking.
This
aims
fill
that
gap
by
providing
systematic
in-depth
overview
recent
advances
application
across
various
regenerative
domains,
including
bone
repair,
cartilage
reconstruction,
angiogenesis,
wound
healing,
nerve
regeneration.
Beyond
presenting
emerging
applications,
places
particular
emphasis
on
elucidating
underlying
mechanisms
through
which
exert
therapeutic
effects.
Although
demonstrate
promise
medicine,
clinical
translation
remains
its
infancy.
To
address
this,
we
not
only
provided
our
insights
into
personalized
problems
arise
tissues,
but
also
discussing
prospecting
common
challenges
LDHs.
These
include
optimizing
synthesis
techniques,
enhancing
biosafety
stability,
improving
drug-loading
efficiency,
designing
composite
materials,
establishing
pathways
facilitate
transition
from
laboratory
research
practice.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(14), P. 6126 - 6176
Published: Jan. 1, 2022
Against
the
backdrop
of
increased
public
health
awareness,
inorganic
nanomaterials
have
been
widely
explored
as
promising
nanoagents
for
various
kinds
biomedical
applications.
Layered
double
hydroxides
(LDHs),
with
versatile
physicochemical
advantages
including
excellent
biocompatibility,
pH-sensitive
biodegradability,
highly
tunable
chemical
composition
and
structure,
ease
composite
formation
other
materials,
shown
great
promise
in
In
this
review,
we
comprehensively
summarize
recent
advances
LDH-based
Firstly,
material
categories
are
discussed.
The
preparation
surface
modification
nanomaterials,
pristine
LDHs,
nanocomposites
LDH-derived
then
described.
Thereafter,
systematically
describe
potential
LDHs
applications
drug/gene
delivery,
bioimaging
diagnosis,
cancer
therapy,
biosensing,
tissue
engineering,
anti-bacteria.
Finally,
on
basis
current
state
art,
conclude
insights
remaining
challenges
future
prospects
rapidly
emerging
field.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(20)
Published: March 19, 2024
Abstract
Layered
double
hydroxides
(LDHs)
have
been
widely
studied
for
biomedical
applications
due
to
their
excellent
properties,
such
as
good
biocompatibility,
degradability,
interlayer
ion
exchangeability,
high
loading
capacity,
pH‐responsive
release,
and
large
specific
surface
area.
Furthermore,
the
flexibility
in
structural
composition
ease
of
modification
LDHs
makes
it
possible
develop
specifically
functionalized
meet
needs
different
applications.
In
this
review,
recent
advances
applications,
which
include
LDH‐based
drug
delivery
systems,
cancer
diagnosis
therapy,
tissue
engineering,
coatings,
functional
membranes,
biosensors,
are
comprehensively
discussed.
From
these
various
research
fields,
can
be
seen
that
there
is
great
potential
possibility
use
However,
at
same
time,
must
recognized
actual
clinical
translation
still
very
limited.
Therefore,
current
limitations
related
on
discussed
by
combining
limited
examples
with
requirements
biomaterials.
Finally,
an
outlook
future
provided.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4683 - 4716
Published: Sept. 2, 2024
About
40%
of
approved
drugs
and
nearly
90%
drug
candidates
are
poorly
water-soluble
drugs.
Low
solubility
reduces
the
drugability.
Effectively
improving
bioavailability
is
a
critical
issue
that
needs
to
be
urgently
addressed
in
development
application.
This
review
briefly
introduces
conventional
solubilization
techniques
such
as
solubilizers,
hydrotropes,
cosolvents,
prodrugs,
salt
modification,
micronization,
cyclodextrin
inclusion,
solid
dispersions,
details
crystallization
strategies,
ionic
liquids,
polymer-based,
lipid-based,
inorganic-based
carriers
bioavailability.
Some
most
commonly
used
carrier
materials
for
presented.
Several
using
summarized.
Furthermore,
this
summarizes
mechanism
each
technique,
reviews
latest
research
advances
challenges,
evaluates
potential
clinical
translation.
could
guide
selection
approach,
dosage
form,
administration
route
Moreover,
we
discuss
several
promising
attracting
increasing
attention
worldwide.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(2), P. 413 - 413
Published: Jan. 26, 2023
The
development
of
biomaterials
has
a
substantial
role
in
pharmaceutical
and
medical
strategies
for
the
enhancement
life
quality.
This
review
work
focused
on
versatile
based
nanocomposites
comprising
organic
polymers
class
layered
inorganic
nanoparticles,
aiming
drug
delivery
(oral,
transdermal,
ocular
delivery)
tissue
engineering
(skin
bone
therapies).
Layered
double
hydroxides
(LDHs)
are
2D
nanomaterials
that
can
intercalate
anionic
bioactive
species
between
layers.
layers
hold
metal
cations
confer
intrinsic
biological
activity
to
LDHs
as
well
biocompatibility.
intercalation
allows
formation
systems
with
elevated
loading
capacity
modified
release
profiles
promoted
by
ion
exchange
and/or
solubilization.
integration,
antigenicity,
stimulation
collagen
formation,
among
other
beneficial
characteristics
LDH,
have
been
observed
vivo
assays.
association
properties
biocompatible
LDH-drug
nanohybrids
produces
multifunctional
compatible
living
matter.
Such
stimuli-responsive,
show
appropriate
mechanical
properties,
be
prepared
creative
methods
allow
fine-tuning
release.
They
processed
end
form
films,
beads,
gels,
monoliths
etc.,
reach
orientated
therapeutic
applications.
Several
studies
attest
higher
performance
polymer/LDH-drug
nanocomposite
compared
hybrid
or
free
drug.
BMEMat,
Journal Year:
2024,
Volume and Issue:
2(2)
Published: Jan. 10, 2024
Abstract
Two‐dimensional
(2D)
nanomaterials,
known
for
their
unique
atomic
arrangements
and
exceptional
physicochemical
properties,
have
garnered
significant
attention
in
biomedical
applications,
particularly
the
realms
of
immunotherapy
tissue
engineering
tumor
therapy.
These
applications
necessitate
a
thorough
assessment
potential
influence
2D
nanomaterials
on
immune
cells.
Notably,
mononuclear
phagocyte
system
(MPS)
cells,
which
play
pivotal
roles
both
innate
adaptive
immunity,
are
essential
maintaining
organismal
homeostasis.
MPS
cells
with
phagocytic
capability
contribute
to
prevention
foreign
body
invasion
elimination
dead
or
senescent
Furthermore,
including
macrophages
dendritic
serve
as
vital
bridges
between
responses.
Therefore,
understanding
nano‐bio
interactions
is
imperative.
cellular
uptake,
cytocompatibility,
immunological
impact
invaluable
purposeful
design
nanomaterials.
Herein,
we
provide
an
overview
latest
advancements
discuss
current
challenges
future
prospects
employing
field
nanomedicine.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Feb. 18, 2024
Abstract
Two-dimensional
nanomaterials
(2D
NMs),
characterized
by
a
large
number
of
atoms
or
molecules
arranged
in
one
dimension
(typically
thickness)
while
having
tiny
dimensions
the
other
two
dimensions,
have
emerged
as
pivotal
class
materials
with
unique
properties.
Their
flat
and
sheet-like
structure
imparts
distinctive
physical,
chemical,
electronic
attributes,
which
offers
several
advantages
biomedical
applications,
including
enhanced
surface
area
for
efficient
drug
loading,
surface-exposed
allowing
precise
chemical
modifications,
ability
to
form
hierarchical
multilayer
structures
synergistic
functionality.
Exploring
their
nano-bio
interfacial
interactions
biological
components
holds
significant
importance
comprehensively
systematically
guiding
safe
applications.
However,
current
lack
in-depth
analysis
comprehensive
understanding
effects
on
cancer
treatment
motivates
our
ongoing
efforts
this
field.
This
study
provides
survey
recent
advances
utilizing
2D
NMs
treatment.
It
insights
into
structural
characteristics,
synthesis
methods,
modifications
diverse
NMs.
The
investigation
further
delves
formation
interfaces
during
vivo
utilization.
Notably,
discusses
wide
array
applications
With
potential
revolutionize
therapeutic
strategies
outcomes,
are
poised
at
forefront
treatment,
holding
promise
transformative
advancements.
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