Polymer-Plastics Technology and Materials,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 23
Published: Dec. 16, 2024
Polymers
have
become
a
versatile
tool
in
pharmaceutical
chemistry
through
techniques
and
new
formulation.
This
review
presents
an
overview
of
the
general
topic
drug
delivery
polymers,
places
particular
focus
on
their
specific
contributions,
discusses
significant
issues
like
biocompatibility,
controlled
release
targeted
delivery.
Unlike
previous
reviews,
it
captures
recent
development
biodegradable,
smart
stimuli-responsive
abilities
to
improve
therapy
outcomes
patient
adherence
treatments.
Furthermore,
this
work
also
has
enhanced
understanding
advanced
polymer-based
systems
such
as
polymeric
nanoparticles,
bioconjugation
strategies
natural
with
examples
various
therapeutic
areas.
The
stands
for
itself
by
expanding
discussion
regulatory
clinical
realism
difficulties
well
safety,
efficacy,
acceptance
considerations.
In
addition,
emphasizes
role
interdisciplinary
intersectoral
cooperation
cross-country
collaborations
developing
polymers-based
applications
precision
medicine.
way,
provides
fresh
view
both
present
advancements
future
possibilities
technologies
dedicated
achievements
globally
inspire
researchers
practitioners.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
Transdermal
drug
delivery
presents
a
promising
noninvasive
approach,
bypassing
first-pass
metabolism
and
gastrointestinal
degradation.
However,
the
stratum
corneum
(SC)
barrier
limits
absorption,
necessitating
development
of
effective
systems.
Microneedles,
particularly
polymer-based
ones,
offer
solution
by
penetrating
SC
while
avoiding
critical
nerves
capillaries.
These
microneedles
are
biodegradable,
nontoxic,
easily
manufacturable,
making
them
highly
attractive
platform
for
transdermal
delivery.
their
clinical
application
remains
limited
due
to
suboptimal
therapeutic
efficacy
slow
release
rates.
Recent
advancements
have
introduced
incorporation
nanodrugs,
such
as
nanoparticles
encapsulated
drugs,
into
enhance
efficiency.
Among
materials
explored,
graphene
its
derivatives,
including
oxide
(GO)
reduced
(rGO),
garnered
significant
attention.
Their
exceptional
mechanical
strength,
electrical
conductivity,
antibacterial
properties
not
only
improve
performance
but
also
rates
biocompatibility.
This
review
synthesizes
current
state
microneedle
technologies,
focusing
on
materials,
fabrication
techniques,
challenges.
It
examines
potential
graphene-based
microneedles,
comparing
traditional
in
terms
efficiency
stability.
The
highlights
key
challenges,
scalability,
biocompatibility,
complexity,
suggests
future
research
directions
address
these
issues.
quantum
dots
(GQDs)
is
identified
avenue
improving
profiles,
stability,
real-time
tracking
diffusion.
Finally,
outlines
emerging
applications,
smart
systems,
biosensing,
monitoring,
urging
further
exploration
unlock
full
graphene-enhanced
settings.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
21(11), P. 1559 - 1572
Published: May 9, 2024
Three-Dimensional
(3D)
microneedles
have
recently
gained
significant
attention
due
to
their
versatility,
biocompatibility,
enhanced
permeation,
and
predictable
behavior.
The
incorporation
of
biological
agents
into
these
3D
constructs
has
advanced
the
traditional
microneedle
an
effective
platform
for
wide-ranging
applications.
Gels,
Journal Year:
2023,
Volume and Issue:
9(10), P. 806 - 806
Published: Oct. 7, 2023
Polymeric
hydrogels
are
a
complex
class
of
materials
with
one
common
feature—the
ability
to
form
three-dimensional
networks
capable
imbibing
large
amounts
water
or
biological
fluids
without
being
dissolved,
acting
as
self-sustained
containers
for
various
purposes,
including
pharmaceutical
and
biomedical
applications.
Transdermal
microneedles
pain-free
drug
delivery
system
that
continues
on
the
path
widespread
adoption—regulatory
guidelines
horizon,
investments
in
field
continue
grow
annually.
Recently,
have
generated
interest
transdermal
due
their
tunable
properties,
allowing
them
be
exploited
systems
extraction
tools.
As
hydrogel
new
emerging
technology,
fabrication
faces
challenges
must
resolved
redeem
themselves
viable
option.
This
article
discusses
from
material
perspective,
regardless
mechanism
action.
It
cites
recent
advances
formulation,
presents
relevant
characterization
methods,
manufacturing
regulatory
facing
these
technologies
before
approval.
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(5), P. 2294 - 2309
Published: April 24, 2024
Bioanalyte
collection
by
blood
draw
is
a
painful
process,
prone
to
needle
phobia
and
injuries.
Microneedles
can
be
engineered
penetrate
the
epidermal
skin
barrier
collect
analytes
from
interstitial
fluid,
arising
as
safe,
painless,
effective
alternative
hypodermic
needles.
Although
there
are
plenty
of
reviews
on
various
types
microneedles
their
use
drug
delivery
systems,
lack
systematization
application
polymeric
for
diagnosis.
In
this
review,
we
focus
current
state
art
field,
while
providing
information
safety,
preclinical
clinical
trials,
market
distribution,
outline
what
believe
will
future
health
monitoring.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(18), P. 2568 - 2568
Published: Sept. 11, 2024
Our
comprehensive
review
plunges
into
the
cutting-edge
advancements
of
polymeric
microneedle
drug
delivery
systems,
underscoring
their
transformative
potential
in
realm
transdermal
administration.
scrutiny
centers
on
substrate
materials
pivotal
for
construction
and
core
properties
that
dictate
efficacy.
We
delve
distinctive
interplay
between
microneedles
dermal
layers,
mechanisms
by
which
this
synergy
enhances
absorption
precision
targeting.
Moreover,
we
examine
acupoint-target
organ-ganglion
nexus,
an
innovative
strategy
steers
concentration
to
specific
targets,
offering
a
paradigm
medicine.
A
thorough
analysis
clinical
applications
systems
is
presented,
highlighting
adaptability
impact
across
spectrum
therapeutic
domains.
This
also
accentuates
systems'
promise
bolster
patient
compliance,
attributed
minimally
invasive
painless
mode
delivery.
present
forward-looking
strategies
aimed
at
optimizing
stimulation
sites
amplify
benefits.
The
anticipation
set
introduction
superior
biocompatible
with
advanced
mechanical
properties,
customizing
cater
specialized
demands.
In
parallel,
deliberate
safety
boosting
loading
capacities
solidifying
efficacy
microneedle-based
therapeutics.
summation,
role
technology
contemporary
healthcare,
charting
course
future
investigative
endeavors
developmental
strides
within
burgeoning
field.
