ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(11), P. 7535 - 7543
Published: Oct. 12, 2024
The
search
for
drug
nanocarriers
with
stimuli-responsive
properties
and
high
payloads
targeted
delivery
precision
medicine
is
currently
a
focal
point
of
biomedical
research,
but
this
endeavor
still
encounters
various
challenges.
Herein,
porous
organic
cage
(POC)
applied
to
paclitaxel
(PTX)
cancer
therapy
the
first
time.
Specifically,
water-soluble,
stable,
biocompatible
POC-based
nanocapsules
(PTX@POC@RH40)
PTX
encapsulation
efficiency
over
98%
can
be
synthesized
by
simply
grafting
nonionic
surfactant
(Polyoxyl
40
hydrogenated
castor
oil,
RH40)
on
POC
surface.
These
PTX@POC@RH40
demonstrate
remarkable
stability
more
than
week
without
aggregation
exhibit
pH-responsive
behavior
under
acidic
conditions
(pH
5.5)
display
sustained
release
at
both
pH
7.4
5.5.
Intravenous
administration
led
3.5-fold
increase
in
bioavailability
compared
free
group
rats.
Moreover,
vivo
mouse
model
experiments
involving
4T1
subcutaneous
breast
tumors
revealed
that
exhibited
enhanced
anticancer
efficacy
minimal
toxicity
PTX.
findings
underscore
potential
POCs
as
promising
therapeutic
applications.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: April 18, 2024
Abstract
Cancer,
a
complex
and
multifactorial
disease,
presents
significant
challenge
to
global
health.
Despite
advances
in
surgical,
radiotherapeutic
immunological
approaches,
which
have
improved
cancer
treatment
outcomes,
drug
therapy
continues
serve
as
key
therapeutic
strategy.
However,
the
clinical
efficacy
of
is
often
constrained
by
resistance
severe
toxic
side
effects,
thus
there
remains
critical
need
develop
novel
therapeutics.
One
promising
strategy
that
has
received
widespread
attention
recent
years
repurposing:
identification
new
applications
for
existing,
clinically
approved
drugs.
Drug
repurposing
possesses
several
inherent
advantages
context
since
repurposed
drugs
are
typically
cost-effective,
proven
be
safe,
can
significantly
expedite
development
process
due
their
already
established
safety
profiles.
In
light
this,
present
review
offers
comprehensive
overview
various
methods
employed
repurposing,
specifically
focusing
on
treat
cancer.
We
describe
antitumor
properties
candidate
drugs,
discuss
detail
how
they
target
both
hallmarks
tumor
cells
surrounding
microenvironment.
addition,
we
examine
innovative
integrating
with
nanotechnology
enhance
topical
delivery.
also
emphasize
role
play
when
used
part
combination
regimen.
To
conclude,
outline
challenges
associated
consider
future
prospects
these
transitioning
into
application.
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
14(3), P. 1132 - 1149
Published: Sept. 3, 2023
Cancer,
a
complex
and
heterogeneous
disease,
arises
from
genomic
instability.
Currently,
DNA
damage-based
cancer
treatments,
including
radiotherapy
chemotherapy,
are
employed
in
clinical
practice.
However,
the
efficacy
safety
of
these
therapies
constrained
by
various
factors,
limiting
their
ability
to
meet
current
demands.
Metal
nanoparticles
present
promising
avenues
for
enhancing
each
critical
aspect
therapy.
Their
customizable
physicochemical
properties
enable
development
targeted
personalized
treatment
platforms.
In
this
review,
we
delve
into
design
principles
optimization
strategies
metal
nanoparticles.
We
shed
light
on
limitations
therapy
while
highlighting
diverse
made
possible
These
encompass
drug
delivery,
inhibition
repair
mechanisms,
induction
cell
death,
cascading
immune
response.
Moreover,
explore
pivotal
role
factors
such
as
nanoparticle
size,
stimuli-responsiveness,
surface
modification
shaping
Finally,
insights
challenges
future
directions
advancing
therapy,
paving
way
novel
paradigms.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(42)
Published: Aug. 25, 2023
Developing
a
drug
delivery
platform
that
possesses
universal
loading
capacity
to
meet
various
requirements
of
cancer
treatment
is
challenging
yet
interesting
task.
Herein,
self-assembled
gelatin/silk
fibroin
composite
(GSC)
particle
based
system
developed
via
microphase
separation
followed
by
desolvation
process.
Thanks
its
preassembled
stage,
this
GSC
suitable
for
varying
types
drugs.
The
process
fix
drugs
inside
rapidly
and
densify
the
structure,
thereby
achieving
efficient
providing
comprehensive
protection
loaded
Actually,
size
brand-new
non-pore
dependent
can
be
easily
adjusted
from
100
nm
20
µm
fit
different
scenarios.
This
work
selects
with
3
diameter
as
inhaled
platform,
which
shows
an
excellent
transmucosal
penetration
lung
retention
ability.
Additionally,
MMP-9
sensitive
degradation
property
enhances
targeted
efficiency
reduces
side
effects.
Intestinally,
self-amplify
regulation
innate
immunity
reverse
cancerous
microenvironment
into
antitumor
niche,
significantly
improving
therapeutic
effect
study
provides
new
direction
develop
next-generation
cancer.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(7), P. 932 - 932
Published: July 12, 2024
Cancer
remains
a
significant
global
health
challenge,
with
traditional
therapies
like
surgery,
chemotherapy,
and
radiation
often
accompanied
by
systemic
toxicity
damage
to
healthy
tissues.
Despite
progress
in
treatment,
these
approaches
have
limitations
such
as
non-specific
targeting,
toxicity,
resistance
development
cancer
cells.
In
recent
years,
nanotechnology
has
emerged
revolutionary
frontier
therapy,
offering
potential
solutions
challenges.
Nanoparticles,
due
their
unique
physical
chemical
properties,
can
carry
therapeutic
payloads,
navigate
biological
barriers,
selectively
target
Metal-based
nanoparticles,
particular,
offer
properties
suitable
for
various
applications.
Recent
advancements
focused
on
the
integration
of
metal-based
nanoparticles
enhance
efficacy
precision
photodynamic
therapy.
Integrating
into
therapy
represents
paradigm
shift,
enabling
strategies
enhanced
specificity
reduced
off-target
effects.
This
review
aims
provide
comprehensive
understanding
pivotal
role
We
explore
mechanisms,
biocompatibility,
applications
highlighting
challenges
use,
well
combining
nanoparticles/photodynamic
other
synergistic
approach
treatment.
Biomarker Research,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Nov. 13, 2024
Lung
cancer
leads
in
causing
cancer-related
mortality
worldwide,
continually
posing
a
significant
threat
to
human
health.
Current
imaging
diagnostic
techniques,
while
offering
non-invasive
detection,
suffer
from
issues
such
as
insufficient
sensitivity
and
the
risks
associated
with
radiation
exposure.
Pathological
diagnosis,
gold
standard
for
confirmation,
also
faces
challenges
like
invasiveness
high
costs.
In
treatment,
surgery,
radiotherapy,
chemotherapy
are
main
modalities,
each
encountering
related
precision,
environmental
adaptability,
side
effects.
Nanotechnology's
advancement
provides
new
solutions
diagnosis
treatment
of
lung
cancer,
promising
enhance
accuracy
reduce
effects
during
treatment.
This
article
introduces
types
nanomaterials
used
field
comprehensive
overview
current
research
on
application
nanotechnology
early
screening,
monitoring
summarizing
ongoing
clinical
findings.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 2, 2024
Abstract
Circulating
tumor
cells
(CTCs)
are
widely
considered
as
a
reliable
and
promising
class
of
markers
in
the
field
liquid
biopsy.
As
CTCs
undergo
epithelial‐mesenchymal
transition
(EMT),
phenotype
detection
heterogeneous
based
on
EMT
is
great
significance.
In
this
report,
an
integrated
analytical
strategy
that
can
simultaneously
capture
differentially
detect
epithelial‐
mesenchymal‐expressed
bloods
non‐small
cell
lung
cancer
(NSCLS)
patients
proposed.
First,
commercial
biomimetic
polycarbonate
(PCTE)
microfiltration
membrane
employed
interface
for
heterogenous
CTCs.
Meanwhile,
differential
captured
realized
by
preparing
two
distinct
CdTe
quantum
dots
(QDs)
with
red
green
emissions,
attached
EpCAM
Vimentin
aptamers,
respectively.
For
combined
analysis,
polydimethylsiloxane
(PDMS)
chip
simple
structure
designed,
which
integrates
QDs‐based
This
not
only
implements
analysis
number
down
to
2
mL
−1
,
but
enables
process
tracking
according
specific
signals
QDs.
Finally,
method
successfully
applied
inspect
correlations
numbers
or
proportions
94
NSCLS
disease
stage
whether
there
distant
metastasis.
