Oxidative stress modulating nanomaterials and their biochemical roles in nanomedicine

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 9(10), P. 1630 - 1682

Published: Jan. 1, 2024

Many pathological conditions are predominantly associated with oxidative stress, arising from reactive oxygen species (ROS); therefore, the modulation of redox activities has been a key strategy to restore normal tissue functions. Current approaches involve establishing favorable cellular environment through administration therapeutic drugs and redox-active nanomaterials (RANs). In particular, RANs not only provide stable reliable means delivery but also possess capacity finely tune various interconnected components, including radicals, enzymes, proteins, transcription factors, metabolites. Here, we discuss roles that engineered play in spectrum conditions, such as cancer, neurodegenerative diseases, infections, inflammation. We visualize dual functions both generator scavenger ROS, emphasizing their profound impact on diverse The focus this review is solely inorganic (inorganic RANs). Additionally, deliberate challenges current RANs-based propose potential research directions for future clinical translation.

Language: Английский

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Single-Atom-Based Nanoenzyme in Tissue Repair

ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12639 - 12671

Published: May 8, 2024

Since the discovery of ferromagnetic nanoparticles Fe3O4 that exhibit enzyme-like activity in 2007, research on nanoenzymes has made significant progress. With in-depth study various and rapid development related nanotechnology, have emerged as a promising alternative to natural enzymes. Within nanozymes, there is category metal-based single-atom nanozymes been rapidly developed due low cast, convenient preparation, long storage, less immunogenicity, especially higher efficiency. More importantly, possess capacity scavenge reactive oxygen species through mechanisms, which beneficial tissue repair process. Herein, this paper systemically highlights types metal their catalytic recent applications repair. The existing challenges are identified prospects future composed metallic nanomaterials proposed. We hope review will illuminate potential repair, encouraging sequential clinical translation.

Language: Английский

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Erythrocyte membrane coated with nitrogen-doped quantum dots and polydopamine composite nano-system combined with photothermal treatment of Alzheimer's disease

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 663, P. 856 - 868

Published: March 2, 2024

Language: Английский

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Interactions between nanoparticles and pathological changes of vascular in Alzheimer’s disease

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115219 - 115219

Published: Feb. 23, 2024

Language: Английский

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Neuromodulation by nanozymes and ultrasound during Alzheimer’s disease management

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 30, 2024

Language: Английский

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Design, Current States, and Challenges of Nanomaterials in Anti-Neuroinflammation: A Perspective on Alzheimer’s Disease

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102669 - 102669

Published: Jan. 1, 2025

Language: Английский

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Nanomedicines for Alzheimer's disease: Therapies based on pathological mechanisms

Brain‐X, Journal Year: 2023, Volume and Issue: 1(3)

Published: July 28, 2023

Abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. Because of complex pathogenesis AD and unique location lesions, effective clinical treatment strategies for this remain elusive. However, development nanotechnology has allowed a new era to emerge. nanomedicines are products interdisciplinary research that enable high precision targeted delivery. Additionally, they can specifically regulate various pathogenic factors. This review focuses on based pathological mechanisms target lesions. We also discuss precise regulatory effects (including nanomaterials themselves) proteins, neuroinflammatory molecules, other summarize trials have examined drugs, highlighting progress in their translation. Nanotechnology‐based nascent field, complete cure distant at present; therefore, we elaborate shortcomings current nanomedicines. Finally, prospects guide future

Language: Английский

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In-situ growth of CeO2 on biofilms: Innovative nanoparticles for photothermal therapy & multi-pronged attack on Alzheimer’s disease

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 238, P. 113887 - 113887

Published: April 1, 2024

Language: Английский

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Two birds with one stone: A multi-functional nanoplatform for sensitive detection and real-time inactivation of pathogenic bacteria with NIR-triggered PTT/PDT

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 481, P. 148649 - 148649

Published: Jan. 8, 2024

Language: Английский

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Serum albumin-embedding copper nanoclusters inhibit Alzheimer’s β-amyloid fibrillogenesis and neuroinflammation

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 672, P. 53 - 62

Published: May 31, 2024

Language: Английский

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