Lipid-Conjugated Reduced Haloperidol in Association with Glucose-Based Nanospheres: A Strategy for Glioma Treatment DOI
Aasia Ansari, Tithi Bhattacharyya, Pritam Das

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Aggressive glioma exhibits a poor survival rate. Increased tumor aggression is linked to both cells and tumor-associated macrophages (TAMs), which induce pro-aggression, invasion, metastasis. Imperatively, for effective treatment, it important target TAMs. Haloperidol, neuropsychotic drug, avidly targets the sigma receptor (SR), expressed in higher levels cell types. Herein, we present development of novel cationic lipid-conjugated reduced haloperidol (±RHPC8), aims mediate SR-targeted antiglioma effect. Hypothetically, ±RHPC8 would act simultaneously as an SR-targeting ligand anticancer agent. As blood-brain barrier (BBB) obstructs direct targeting situ glioma, used BBB-crossing glucose-based carbon nanospheres (CSPs) deliver within tumor-bearing mouse brain. The resultant ±RHPC8-CSP nanoconjugate targeted SR-expressing cells. In orthotopic subcutaneous models, prolonged regressed tumors compared other treated groups. Notably, was significantly taken up by TAMs thus resulting macrophage polarization from M2 M1, exhibited markedly expression immunosuppressive cytokines released TAMs, including TGF-β, IL-10, VEGF. conclusion, designed presented nanodrug delivery system brain cancer treatment.

Language: Английский

Current advance of nanotechnology in diagnosis and treatment for malignant tumors DOI Creative Commons

Bilan Wang,

Shiqi Hu, Yan Teng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

Citations

99
Brain-Targeting Drug Delivery Systems: The State Of The Art In Treatment Of Glioblastoma DOI Creative Commons

Bo Sun,

Rong Li, Ning Ji

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101443 - 101443

Published: Jan. 5, 2025

Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and poor prognosis. The blood-brain barrier (BBB) blood-tumor (BTB) present significant obstacles to efficacy of tumor-targeted pharmacotherapy, thereby impeding therapeutic potential numerous candidate drugs. Targeting delivery adequate doses drug across BBB treat GBM has become prominent research area in recent years. This emphasis driven exploration evaluation diverse technologies for with some already undergoing clinical trials. review provides thorough overview advancements challenges targeted treatment. It specifically emphasizes systemic administration strategies assess their limitations Furthermore, this highlights promising future directions development intelligent systems aimed at overcoming current enhancing against GBM. These not only support foundational on but also offer methodological approaches applications.

Language: Английский

Citations

4
Advanced Nanoparticle Engineering for Precision Therapeutics of Brain Diseases DOI
Muhammad Ismail, Jiayi Liu,

Ningyang Wang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123138 - 123138

Published: Jan. 28, 2025

Language: Английский

Citations

3
Diversity of extracellular HSP70 in cancer: advancing from a molecular biomarker to a novel therapeutic target DOI Creative Commons
Binbin Hu, Guihong Liu, Kejia Zhao

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 5, 2024

Heat shock protein 70 (HSP70) is a highly conserved functioning as “molecular chaperone”, which integral to folding and maturation. In addition its high expression within cells upon stressful challenges, HSP70 can be translocated the cell membrane or released from in free form extracellular vesicles (EVs). Such trafficking of also present cancer cells, overexpressed various types patient samples across range common malignancies, signifying that (eHSP70) serve tumor biomarker. eHSP70 involved broad cancer-related events, including proliferation apoptosis, matrix (ECM) remodeling, epithelial-mesenchymal transition (EMT), angiogenesis, immune response. induce resistance treatments, such chemotherapy, radiotherapy, anti-programmed death-1 (PD-1) immunotherapy. Though role tumors contradictory, characterized by both pro-tumor anti-tumor effects, serves promising target treatment. this review, we comprehensively summarized current knowledge about progression treatment discussed feasibility biomarker therapeutic target.

Language: Английский

Citations

13
Metformin‐Mediated Immunosuppressive Microenvironment Remodeling in Combination with Chemotherapy via a Spatial‐Specific Multi‐Responsive Carrier‐Free Self‐Assembled Nanoparticle DOI
Yujun Song,

Yufan Du,

Chuan Hu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(25)

Published: Jan. 28, 2024

Abstract The complex tumor immune pathology requires a precise spatial‐control release of the combination drugs, but most multi‐drug loaded nanoparticles all drugs simultaneously in microenvironment (TME), making them difficult to reach exact action site. To address spatial specific carrier‐free self‐assembled multi‐responsive nanodrug delivery system is designed, which p ‐phthalaldehyde ( ‐APA) and dithiodipropionic acid are used connect metformin (MET) 7‐ethyl‐10‐hydroxycamptothecin (SN38) through matrix metalloproteinase‐2 (MMP‐2) responsive peptide, dipyridamole (DIP) further (MA‐GPLGVRGDK‐SS‐SN38@DIP, MR NPs). NPs first target by enhanced permeability retention effect, then highly expressed MMP‐2 at site cleaves GPLGVRGDK, breaking nanoparticle into three parts—DIP, MA‐GPLG, VRGDK‐SS‐SN38. DIP automatically binds with platelets TME, inhibiting their function restraining metastasis. MA‐GPLG releases MET response acidic TME reverse immunosuppressive networks PD‐L1 downregulation M2‐like macrophages repolarization. Moreover, VRGDK‐SS‐SN38 overexpressed integrin α v β 3 receptor achieve cells killing. Overall, this study offers an intelligent spatial‐specific drug breast cancer, specifically, therefore reverses inhibits

Language: Английский

Citations

11
Nanomedicine facilitated cell signaling blockade: difficulties and strategies to overcome glioblastoma DOI

Mohammad Habeeb,

Hariharan Thirumalai Vengateswaran, Huay Woon You

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(7), P. 1677 - 1705

Published: Jan. 1, 2024

Nanocarriers loaded with anticancer agents strategically intervene to block cell signaling pathways in glioblastoma.

Language: Английский

Citations

9
Blood–Brain Barrier Conquest in Glioblastoma Nanomedicine: Strategies, Clinical Advances, and Emerging Challenges DOI Open Access
Mengyun Duan,

Ruina Cao,

Yuan Yang

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(19), P. 3300 - 3300

Published: Sept. 27, 2024

Glioblastoma (GBM) is a prevalent type of malignancy within the central nervous system (CNS) that associated with poor prognosis. The standard treatment for GBM includes surgical resection tumor, followed by radiotherapy and chemotherapy; yet, despite these interventions, overall outcomes remain suboptimal. blood–brain barrier (BBB), which plays crucial role in maintaining stability brain tissue under normal physiological conditions CNS, also poses significant obstacle to effective delivery therapeutic agents GBMs. Recent preclinical studies have demonstrated nanomedicine systems (NDDSs) offer promising results, demonstrating both targeting safety, thereby presenting potential solution targeted drug delivery. In this review, we first explore various strategies employed overcome BBB Subsequently, results clinical translation NDDSs are summarized, highlighting progress made. Finally, discuss advancing development accelerating their translational research through well-designed trials therapy.

Language: Английский

Citations

8
A Self‐Cascading Catalytic Therapy and Antigen Capture Scaffold‐Mediated T Cells Augments for Postoperative Brain Immunotherapy DOI

Bhanu Nirosha Yalamandala,

Thrinayan Moorthy, Zhuo‐Hao Liu

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract The recruitment of T lymphocytes holds great potential for suppressing the most aggressive glioblastoma (GBM) recurrence with immunotherapy. However, phenomenon immune privilege and generally low immunogenicity vaccines often reduce presence within brain tumors, especially in tumor clusters. In this study, an implantable self‐cascading catalytic therapy antigen capture scaffold (CAS) that can boost efficiency at post‐surgery antigens via urethane‐polyethylene glycol‐polypropylene glycol (PU‐EO‐PO) segments are developed postoperative CAS consists 3D‐printed elastomers modified iron (Fe 2+ ) metal‐organic frameworks (MOFs, MIL88) acts as a programmed peroxide mimic cancer cells to initiate Fenton reaction sustain ROS production. With assistance chloroquine (CQ), autophagy is inhibited through lysosome deacidification, which interrupts self‐defense mechanism, further enhances cytotoxicity, releases antigens. Then, containing PU‐EO‐PO groups depot detain autologous tumor‐associated dendritic maturation cell augments sustained stimulation. enhanced response tumors improved survival

Language: Английский

Citations

8
Biomimetic platelet-like nanoparticles enhance targeted hepatocellular carcinoma therapy DOI
Yuesong Wu, Qingze Fan,

Jiahan Zhou

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 240, P. 113973 - 113973

Published: May 16, 2024

Language: Английский

Citations

5
Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment DOI
Yulei Mu, Zhen Zhang, Huiqun Zhou

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(16), P. 4045 - 4064

Published: Jan. 1, 2024

With the increasing research and deepening understanding of glioblastoma (GBM) tumour microenvironment (TME), novel more effective therapeutic strategies have been proposed. The GBM TME involves intricate interactions between non-tumour cells, promoting progression. Key goals for treatment include improving immunosuppressive microenvironment, enhancing cytotoxicity immune cells against tumours, inhibiting growth proliferation. Consequently, remodeling using nanotechnology has emerged as a promising approach. Nanoparticle-based drug delivery enables targeted delivery, thereby specificity, facilitating combination therapies, optimizing metabolism. This review provides an overview discusses methods nanotechnology. Specifically, it explores application in ameliorating cell immunosuppression, inducing immunogenic death, stimulating, recruiting regulating metabolism, modulating crosstalk tumours other cells.

Language: Английский

Citations

5