Single‐Atom Nanozymes for Catalytic Therapy: Recent Advances and Challenges

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(16)

Published: Jan. 4, 2024

Abstract As a powerful tool, nanozyme catalysts broaden the avenues to implement bio‐inspired solutions for addressing many important concerns, covering energy, healthcare, environment, and more. Recent endeavors, characterized by atomic precision, have enabled extensive exploration of single‐atom nanozymes (SAzymes) with high catalytic activity, superior substrate selectivity, integrated multifunctionalities, thus becoming an emerging field that bridges nanotechnology biology. This review provides brief outline progress summarizes latest research advances regarding SAzymes in biomedical therapeutics, mainly including tumor therapy, wound antibacterial tissue anti‐inflammatory focus on their prototypical synthesis therapeutic mechanisms. Finally, current challenges future perspectives engineering advanced are also discussed outlooked. It is anticipated this area shall provide useful guidance therapy.

Language: Английский

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Single-Atom Nanozymes: From Precisely Engineering to Extensive Applications

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(3), P. 347 - 357

Published: Feb. 3, 2024

ConspectusNanozymes are nanomaterials with intrinsic enzyme-like properties that can overcome the current limitations of natural enzymes, such as high preparation cost, instability, restricted application scenarios, etc. Since Fe3O4 nanoparticles (NPs) were shown to possess peroxidase (POD)-like activity in 2007, thousands reported mimic catalytic various types enzymes including catalase (CAT), haloperoxidase, superoxide dismutase (SOD), glucose oxidase, glutathione peroxidase, hydrolase, nuclease, nitroreductase, and others. Particularly, some nanozymes showed multienzyme-like activities regarding changes scenarios temperature, pH, Benefiting from their distinct physical-chemical characteristics properties, have been widely applied biomedical related fields vitro detections vivo therapeutic treatments. However, currently ambiguous structure–function correlations relatively inferior compared promote extensive efforts for modifications on development novel alternative nanozymes. The single-atom (SAzymes) present a unique way highly evolved enzyme active centers, because atomically dispersed sites, which leads atom utilization efficiency and, thus, potentially extraordinary activity. Also, abilities modify centers and/or tune interactions between metal supporting ligands provide precise engineer SAzymes at atomic levels. Given well-defined geometric electronic structures, thus serve exceptional templates deciphering relationships, is beneficial further improving performances.In this Account, we will review our recent other notable works developments effective mimics applications areas. We begin brief introduction why emergence SAzymes, artificial enzyme, tackles challenges facing. Next, focus systematic design, synthesis optimization especially impacts engineering environment an enzymologist perspective. For example, alternations first-shell ligand N P/S, SAzymes' CAT-like increased more than 4-fold. coordination numbers (x) Co–Nx(C) SAzyme significantly altered its oxidase (OXD)-like kinetics Then, discuss ways standardization specific kinetics. also wide ranges colorimetric biologicals, antibiosis treatments, cancer therapies. Finally, address future perspectives

Language: Английский

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NIR-enhanced Pt single atom/g-C3N4 nanozymes as SOD/CAT mimics to rescue ATP energy crisis by regulating oxidative phosphorylation pathway for delaying osteoarthritis progression

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 1 - 13

Published: Feb. 21, 2024

Osteoarthritis (OA) progresses due to the excessive generation of reactive oxygen and nitrogen species (ROS/RNS) abnormal ATP energy metabolism related oxidative phosphorylation pathway in mitochondria. Highly active single-atom nanozymes (SAzymes) can help regulate redox balance have shown their potential treatment inflammatory diseases. In this study, we innovatively utilised ligand-mediated strategies chelate Pt

Language: Английский

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Optimizing single-atom cerium nanozyme activity to function in a sequential catalytic system for colorimetric biosensing

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102236 - 102236

Published: April 1, 2024

Language: Английский

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NIR-II Light-Driven Genetically Engineered Exosome Nanocatalysts for Efficient Phototherapy against Glioblastoma

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(22), P. 15251 - 15263

Published: May 23, 2024

Glioblastoma (GBM) poses a significant therapeutic challenge due to its invasive nature and limited drug penetration through the blood–brain barrier (BBB). In response, here we present an innovative biomimetic approach involving development of genetically engineered exosome nanocatalysts (Mn@Bi2Se3@RGE-Exos) for efficient GBM therapy via improving BBB enzyme-like catalytic activities. Interestingly, photothermally activatable multiple reactivity is observed in such nanosystem. Upon NIR-II light irradiation, Mn@Bi2Se3@RGE-Exos are capable converting hydrogen peroxide into hydroxyl radicals, oxygen, superoxide providing peroxidase (POD), oxidase (OXD), catalase (CAT)-like nanocatalytic cascade. This consequently leads strong oxidative stresses damage cells. vitro, vivo, proteomic analysis further reveal potential disruption cellular homeostasis, enhancement immunological induction cancer cell ferroptosis, showcasing great promise anticancer efficacy against with favorable biosafety profile. Overall, success this study provides feasible strategy future design clinical stimuli-responsive medicine, especially context challenging brain cancers like GBM.

Language: Английский

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Immunological nanomaterials to combat cancer metastasis

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(12), P. 6399 - 6444

Published: Jan. 1, 2024

This review highlights recent advances in immunological nanomaterials against metastasis and summarizes various nanomaterial-mediated immunotherapy strategies.

Language: Английский

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Targeted Delivery of Active Sites by Oxygen Vacancy-Engineered Bimetal Silicate Nanozymes for Intratumoral Aggregation-Potentiated Catalytic Therapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(2), P. 1516 - 1530

Published: Jan. 3, 2024

Biodegradable silicate nanoconstructs have aroused tremendous interest in cancer therapeutics due to their variable framework composition and versatile functions. Nevertheless, low intratumoral retention still limits practical application. In this study, oxygen vacancy (OV)-enriched bimetallic nanozymes with Fe–Ca dual active sites via modification of oxidized sodium alginate gallic acid (GA) loading (OFeCaSA-V@GA) were developed for targeted aggregation-potentiated therapy. The band gap silica markedly decreased from 2.76 1.81 eV by codoping Fe3+ Ca2+, enabling its excitation a 650 nm laser generate reactive species. OV that occurred the hydrothermal synthetic stage OFeCaSA-V@GA can anchor metal ions form an atomic phase, offering massive fabrication method single-atom nanozymes. Density functional theory results reveal Ca promote adsorption H2O2, Fe accelerate dissociation thereby realizing synergetic catalytic effect. More importantly, delivery induce morphological transformation at tumor sites, leading high (the highest rate is 36.3%) theranostic components cells. Thus, finding may offer ingenious protocol designing engineering highly efficient long-retention nanodrugs.

Language: Английский

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Single-Atom-Based Nanoenzyme in Tissue Repair

ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12639 - 12671

Published: May 8, 2024

Since the discovery of ferromagnetic nanoparticles Fe3O4 that exhibit enzyme-like activity in 2007, research on nanoenzymes has made significant progress. With in-depth study various and rapid development related nanotechnology, have emerged as a promising alternative to natural enzymes. Within nanozymes, there is category metal-based single-atom nanozymes been rapidly developed due low cast, convenient preparation, long storage, less immunogenicity, especially higher efficiency. More importantly, possess capacity scavenge reactive oxygen species through mechanisms, which beneficial tissue repair process. Herein, this paper systemically highlights types metal their catalytic recent applications repair. The existing challenges are identified prospects future composed metallic nanomaterials proposed. We hope review will illuminate potential repair, encouraging sequential clinical translation.

Language: Английский

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Single‐Atom Iridium‐doped Carbon Dots Nanozyme with High Peroxidase‐Like Activity as Colorimetric Sensors for Multimodal Detection of Mercury Ions

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Nanozyme-based colorimetric sensors are promising approaches for environmental monitoring, food safety, and medical diagnostics. However, developing novel nanozymes that exhibit high catalytic activity, good dispersion in aqueous solution, sensitivity, selectivity, stability is challenging. In this study, the first time, single-atom iridium-doped carbon dot (SA Ir-CDs) synthesized via a simple situ pyrolysis process. Doping dots with iridium form of single atoms to achieve maximum atomic utilization not only enhances peroxidase (POD)-like activity 178.81 U mg-1 but also improves dispersibility solutions over 30 days. Hence, SA Ir-CD platform developed mercury ions (Hg2+) detection exhibited linear relationship from 0.01 10 µm limit 4.4 nm. Notably, changes color can be observed through naked eye smartphone, enabling convenient field onsite monitoring without need sophisticated analytical equipment. an approach fabricating metal-based POD-like developed, new effective easy-to-use sensor Hg2+ constructed.

Language: Английский

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Copper-instigated modulatory cell mortality mechanisms and progress in oncological treatment investigations

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 2, 2023

Copper, a transition metal, serves as an essential co-factor in numerous enzymatic active sites and constitutes vital trace element the human body, participating crucial life-sustaining activities such energy metabolism, antioxidation, coagulation, neurotransmitter synthesis, iron tetramer deposition. Maintaining equilibrium of copper ions within biological systems is paramount importance prevention atherosclerosis associated cardiovascular diseases. Copper induces cellular demise through diverse mechanisms, encompassing reactive oxygen species responses, apoptosis, necrosis, pyroptosis, mitochondrial dysfunction. Recent research has identified dubbed novel regulatory cell death modality—”cuprotosis”—wherein bind to acylated proteins tricarboxylic acid cycle respiration, resulting protein aggregation, subsequent downregulation iron-sulfur cluster expression, induction proteotoxic stress, eventual death. Scholars have synthesized complexes by combining with various ligands, exploring their significance applications cancer therapy. This review comprehensively examines multiple pathways copper-induced death, current status treatment.

Language: Английский

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