Electrical
stimulation
has
been
shown
to
enhance
tissue
regeneration,
which
is
why
piezoelectric-polymer-based
scaffolds
are
on
the
rise
for
advanced
tissue-engineering
approaches.
Recent
studies
have
that
electrical
cues
can
modulate
cell
function
in
vitro
and
vivo
these
be
delivered
through
application
of
an
external
noninvasive
ultrasound
(US)
source
actuate
a
piezoelectric
polymer.
However,
poly(l-lactide)
(PLLA)
possesses
shear
coefficient
therefore
requires
different
strategies
US
relative
other
well-established
materials
such
as
poly(vinylidene
fluoride-trifluoroethylene)
P(VDF-TrFE).
Thus,
this
work
compares
three
methods
ranging
from
1
500
kHz
(a
nanokicking
bioreactor,
transducer,
bath)
PLLA
diaphragm
with
aim
creating
bioelectrical
culture
device.
The
bath
stimulated
films
(37
kHz)
generated
output
voltage
548
±
16
mV,
highest
all
tested
systems.
nanokicker
(1.3
were
associated
4.8
0.7
probe
(500
actuated
9.1
0.8
still
high
enough
stimulation.
Moreover,
influence
film
tension
was
examined,
reduced
observed
increase
response
by
118%
reduce
P(VDF-TrFE)
24%.
This
shows
PLLA-based
designed
manner
take
advantage
effect
PLLA,
when
applying
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(40)
Published: May 15, 2024
Abstract
Prevention
of
aseptic
loosening,
the
main
reason
for
secondary
surgery
bone
implants,
is
great
crucial
clinical
importance.
As
a
promising
bioactive
material
to
promote
regeneration,
piezoelectric
materials
preventing
loosening
has
not
been
reported.
Here,
surface
coating
presented
implants
based
on
poly(L‐lactic
acid)
(PLLA).
The
ingeniously
utilizes
zoledronic
acid
(ZA),
drug
used
treat
osteoporosis,
as
nucleating
agent
enhance
piezoelectricity
PLLA.
can
only
provide
continuous
porous
environment
stimulate
osteogenic
differentiation
without
intervention,
but
also
effectively
inhibit
osteolytic
activity
osteoclasts
through
slow
release
ZA,
achieving
long‐term
effectiveness
with
single
implantation.
rat
femur
cavity
implantation
experiment
suggests
that,
PLLA/ZA
rapidly
initiate
osseointegration
implant
and
mitigate
risk
even
in
presence
metal
submicroscopic
particles
that
induce
loosening.
This
strategy
piezo‐enhanced
PLLA
drug‐loaded
may
new
idea
modification
implants.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 8, 2025
Sonodynamic
therapy
(SDT)
represents
a
promising
approach
for
cancer
treatment.
Compared
to
photodynamic
therapy,
SDT
offers
increased
penetration
depth
and
higher
precision.
However,
the
practical
application
of
is
constrained
by
low
water
solubility,
poor
tumor
specificity,
metabolic
susceptibility
most
sonosensitizers.
Recent
research
has
explored
use
piezoelectric
materials
as
sonosensitizers
in
treatment
inhibition
bacterial
growth.
Upon
ultrasound
excitation,
separation
electron-hole
(e--h+)
pairs
occurs
within
material.
By
improving
crystal
structure
material
or
incorporating
other
nanoparticles
prevent
rapid
recombination
e--h+
pairs,
accumulates
charges
conduction
band
valence
band,
achieving
redox
potential
O2/·O2
-.
This
enables
serve
sonosensitizer,
leading
concept
termed
Sono-Piezo
Dynamic
Therapy
(SPDT).
review
aims
define
SPDT,
provide
systematic
overview
historical
development
SDT,
elucidate
mechanisms
which
act
Importantly,
various
will
be
discussed
terms
their
feasibility,
advantages,
disadvantages
sonosensitizers,
offering
new
perspectives
identifying
ACS Applied Polymer Materials,
Journal Year:
2024,
Volume and Issue:
6(13), P. 7561 - 7571
Published: June 27, 2024
The
shear
piezoelectricity
of
polylactide
(PLA)
depends
on
the
chain
orientation,
crystallinity,
and
optical
purity,
but
their
combined
influence
piezoelectric
properties
has
never
been
studied.
This
work
examines
effect
purity
morphology
induced
by
cold-drawing
heat
treatment.
Moreover,
force
frequency
during
dynamic
mechanical
activation
response
PLA
was
results
this
present
for
first
time
a
coefficient
purely
amorphous
as-drawn
film
(d14
=
2.3
±
0.1
pC
N–1),
exhibiting
high
orientation
without
crystallites,
leading
to
ductile
behavior.
Postdrawn
annealing
increased
157%
due
crystallinity
crystal
resulting
in
brittle
Upon
increasing
from
88
99%
l-isomer
content,
(d14)
shown
be
improved
degree
lamellar
thickness.
Dynamic
analysis
revealed
linear
strain
rate
dependence
PLA.
led
further
increase
470%
1
kHz.
These
unfold
potential
fabrication
films
with
ductility
final
biomedical
applications.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(19), P. 2797 - 2797
Published: Oct. 2, 2024
Bone
repair
and
regeneration
require
physiological
cues,
including
mechanical,
electrical,
biochemical
activity.
Many
biomaterials
have
been
investigated
as
bioactive
scaffolds
with
excellent
electrical
properties.
Amongst
biomaterials,
piezoelectric
materials
(PMs)
are
gaining
attention
in
biomedicine,
power
harvesting,
biomedical
devices,
structural
health
monitoring.
PMs
unique
properties,
such
the
ability
to
affect
movements
deliver
stimuli
damaged
bone
or
cells
without
an
external
source.
The
crucial
property
is
its
piezoelectricity.
Bones
can
generate
charges
potential
response
mechanical
stimuli,
they
influence
growth
regeneration.
Piezoelectric
respond
human
microenvironment
important
factor
repair.
This
manuscript
overview
of
fundamentals
generating
effect
their
on
paper
focuses
state
art
materials,
polymers,
ceramics,
composites,
application
tissue
engineering.
We
present
information
from
point
view
highlight
promising
upcoming
approaches
new
generations
materials.
Advanced Materials Technologies,
Journal Year:
2024,
Volume and Issue:
9(12)
Published: April 12, 2024
Abstract
Cough
is
a
common
symptom
of
various
respiratory
diseases.
However,
recognizing
subject's
cough
using
acoustic
imaging
can
be
challenging
due
to
the
complexity
coughing
and
vulnerability
acquisition
external
interference.
This
research
aims
address
these
issues
by
utilizing
flexible
piezoelectric
ionic
liquid‐doped
poly(L‐lactic
acid)
(PLLA)
sensor
gather
pressure
signals
from
human
surface.
1‐butyl‐3‐methylimidazolium
bis
(trifluoromethylsulfonyl)imide
([BMIm]TFSI)
liquid
(IL)
enhance
performance
PLLA
thin
film,
corresponding
output
voltage,
impact
sensitivity
are
improved
three
times
105.1%
for
PLLA/IL
film
with
1
wt%
IL,
140
°C
annealing
2
h
four
drawing
ratio.
The
effect
IL
on
crystallization
behavior
properties
films
during
their
preparation
investigated.
integrated
into
wearable
electronic
system
which
collects
transmits
cough‐induced
vibrations
filter
denoising,
then
acquired
data
decomposed
Empirical
Mode
Decomposition
method
trained
in
multi‐layer
perception
model
detect
coughing.
It's
evident
that
sensors
applied
recognition
show
great
potential
applications
intelligent
healthcare.
Journal of Functional Biomaterials,
Journal Year:
2023,
Volume and Issue:
14(6), P. 299 - 299
Published: May 28, 2023
Exosomes
have
been
proven
to
play
a
positive
role
in
tendon
and
tendon–bone
healing.
Here,
we
systematically
review
the
literature
evaluate
efficacy
of
exosomes
Following
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
guidelines,
systematic
comprehensive
was
performed
on
21
January
2023.
The
electronic
databases
searched
included
Medline
(through
PubMed),
Web
Science,
Embase,
Scopus,
Cochrane
Library
Ovid.
In
end,
total
1794
articles
were
reviewed.
Furthermore,
“snowball”
search
also
carried
out.
Finally,
forty-six
studies
analysis,
with
sample
size
being
1481
rats,
416
mice,
330
rabbits,
48
dogs,
12
sheep.
these
studies,
promoted
healing
displayed
improved
histological,
biomechanical
morphological
outcomes.
Some
suggested
mechanism
promoting
healing,
mainly
through
following
aspects:
(1)
suppressing
inflammatory
response
regulating
macrophage
polarization;
(2)
gene
expression,
reshaping
cell
microenvironment
reconstructing
extracellular
matrix;
(3)
angiogenesis.
risk
bias
low
whole.
This
provides
evidence
effect
preclinical
studies.
unclear-to-low
highlights
significance
standardization
outcome
reporting.
It
should
be
noted
that
most
suitable
source,
isolation
methods,
concentration
administration
frequency
are
still
unknown.
Additionally,
few
used
large
animals
as
subjects.
Further
may
required
comparing
safety
different
treatment
parameters
animal
models,
which
would
conducive
design
clinical
trials.
Small Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Piezoelectric
micro‐
and
nanomaterials
can
generate
local
electrical
signals
when
subjected
to
mechanical
stress,
a
phenomenon
that
be
exploited
trigger
beneficial
effects
at
the
cell
tissue
level.
In
recent
years,
research
on
biodegradable
piezoelectric
material
has
gained
momentum,
as
these
materials
degrade
after
fulfilling
their
function.
Thus,
they
promise
considerably
impact
regenerative
medicine,
targeted
therapy,
microrobotics,
with
better
chances
match
regulatory
requirements
respect
nondegradable
counterparts.
This
review
offers
comprehensive
overview
of
advancements
in
nanomaterials,
focusing
mechanisms,
types,
methods
enhance
properties.
Current
characterization
techniques,
emphasizing
both
piezoelectricity
biodegradability
micro/nano
scale,
are
also
discussed.
Furthermore,
it
is
discussed
how
use
intelligent
platforms
for
medicine
responsive
drug
delivery
systems.
The
application
microrobotics
examined,
particularly
potential
minimally
invasive
procedures.
Finally,
challenges
future
directions
highlighted,
underscoring
importance
versatile
advancing
biomedical
technologies.
