Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

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Emerging nitric oxide gas‐assisted cancer photothermal treatment

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 24, 2024

Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.

Language: Английский

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Endoplasmic Reticulum‐Targeting Iridium(III) Nanosonosensitizer Amplifies Immunogenic Cell Death for Boosted Tumor Sono‐Immunotherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)

Published: Feb. 27, 2024

Abstract Reactive oxygen species (ROS)‐induced endoplasmic reticulum (ER) stress in sonodynamic therapy (SDT) can elicit immunogenic cell death (ICD)‐initiated antitumor immunity for augmented sono‐immunotherapy. However, unsatisfactory activity and mediocre ER induction ability of sonosensitizers essentially restrict SDT efficacy ICD stimulation. Herein, a versatile ER‐targeting Iridium(III) nanosonosensitizer is developed as superior inducer boosted tumor An ingenious cholic acid (CA)‐functionalized sonosensitizer Ir‐CA well‐designed skillfully crosslinked with human serum albumin (HSA) to form HSA@Ir‐CA. With high stability, favorable tumor‐targeting ability, reduction‐responsiveness, HSA@Ir‐CA preferentially accumulates sites enhanced cellular uptake, followed by rapid disassembly responding intracellular reductive environment. The uncaged selectively accumulate precisely disrupt situ produced type I II ROS upon US irradiation high‐efficiency SDT. Moreover, the maximized eminently amplifies evoke robust systemic immunity, inhibiting growths primary/distant tumor, lung metastasis, recurrence. This combined immune checkpoint inhibitor (αPD‐L1) further achieves reinforced therapeutic outcome against immunologically “cold” tumor. study presents an effective paradigm optimize amplify ICD‐initiated responses

Language: Английский

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Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 16, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain

Language: Английский

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Iridium nanoparticles supported on polyaniline nanotubes for peroxidase mimicking towards total antioxidant capacity assay of fruits and vegetables

Food Chemistry, Journal Year: 2024, Volume and Issue: 445, P. 138732 - 138732

Published: Feb. 13, 2024

Language: Английский

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Dual‐Programmable Semiconducting Polymer NanoPROTACs for Deep‐Tissue Sonodynamic‐Ferroptosis Activatable Immunotherapy

Small, Journal Year: 2023, Volume and Issue: 20(8)

Published: Oct. 10, 2023

Abstract Proteolysis‐targeting chimeras (PROTACs) can provide promising opportunities for cancer treatment, while precise regulation of their activities remains challenging to achieve effective and safe therapeutic outcomes. A semiconducting polymer nanoPROTAC (SPN FeP ) is reported that ultrasound (US) tumor microenvironment dual‐programmable PROTAC activity deep‐tissue sonodynamic‐ferroptosis activatable immunotherapy. SPN formed through a nano‐precipitation sonodynamic polymer, ferroptosis inducer, newly synthesized molecule. The polymers work as sonosensitizers produce singlet oxygen ( 1 O 2 via effect under US irradiation, inducers react with intratumoral hydrogen peroxide (H generate hydroxyl radical (·OH). Such reactive species (ROS) generation not only triggers immunogenic cell death (ICD), but also induces on‐demand delivery molecules into sites. effectively activated nanoPROTACs degrade nicotinamide phosphoribosyl transferase (NAMPT) suppress infiltration myeloid‐derived suppressive cells (MDSCs), thus promoting antitumor immunity. In such way, mediates immunotherapy entirely inhibiting growths in both subcutaneous 2‐cm tissue‐covered deep mouse models. This study presents strategy based on PROTACs combinational therapy.

Language: Английский

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Transition-Metal-Oxide-Based Nanozymes for Antitumor Applications

Materials, Journal Year: 2024, Volume and Issue: 17(12), P. 2896 - 2896

Published: June 13, 2024

Transition metal oxide (TMO)-based nanozymes have appeared as hopeful tools for antitumor applications due to their unique catalytic properties and ability modulate the tumor microenvironment (TME). The purpose of this review is provide an overview latest progress made in field TMO-based nanozymes, focusing on enzymatic activities participating ions. These exhibit catalase (CAT)-, peroxidase (POD)-, superoxide dismutase (SOD)-, oxidase (OXD)-, glutathione (GSH-OXD)-like activities, enabling them regulate reactive oxygen species (ROS) levels (GSH) concentrations within TME. Widely studied transition metals include Fe, Mn, Cu, Ce, hybrid multimetallic oxides, which are also summarized. highlights several innovative nanozyme designs multifunctional capabilities. Despite significant challenges such long-term biosafety, targeting precision, mechanisms, theoretical supports remain be addressed, these discussed. This contributes summary understanding rapid development holds great promise advancing nanomedicine improving cancer treatment.

Language: Английский

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Sulfur/nitrogen co-doped carbon-based copper nanozyme with high peroxidase-like activity for dual-channel paper-based detection of melatonin

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 418, P. 136246 - 136246

Published: July 4, 2024

Language: Английский

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Nanozyme-based cancer theranostics: A scientometric analysis and comprehensive review

Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102386 - 102386

Published: July 13, 2024

Language: Английский

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Amino acid-based metallo-supramolecular nanoassemblies capable of regulating cellular redox homeostasis for tumoricidal chemo-/photo-/catalytic combination therapy

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 663, P. 810 - 824

Published: Feb. 29, 2024

Language: Английский

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