World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(11), P. 956 - 973
Published: Nov. 25, 2024
Recent advancements in nanomedicine have highlighted the potential of exosome (Ex)-based therapies, utilizing naturally derived nanoparticles, as a novel approach to targeted cancer treatment.
Language: Английский
Bioactive Materials, Journal Year: 2024, Volume and Issue: 44, P. 131 - 151
Published: Oct. 15, 2024
Language: Английский
Citations
18
Small, Journal Year: 2024, Volume and Issue: 20(29)
Published: Feb. 20, 2024
As the global population ages, bone diseases have become increasingly prevalent in clinical settings. These conditions often involve detrimental factors such as infection, inflammation, and oxidative stress that disrupt homeostasis. Addressing these disorders requires exogenous strategies to regulate osteogenic microenvironment (OME). The regulation of OME can be divided into four processes: induction, modulation, protection, support, each serving a specific purpose. To this end, metal-organic frameworks (MOFs) are an emerging focus nanomedicine, which show tremendous potential due their superior delivery capability. MOFs play numerous roles metal ion donors, drug carriers, nanozymes, photosensitizers, been extensively explored recent studies. This review presents comprehensive introduction by MOF-based nanomaterials. By discussing various functional MOF composites, work aims inspire guide creation sophisticated efficient nanomaterials for disease management.
Language: Английский
Citations
12
Deleted Journal, Journal Year: 2024, Volume and Issue: 2(3)
Published: May 29, 2024
Abstract The skin interfaces with the external environment, acting as both a physical barrier and an immunologic defense. dynamic interactions between various cell types are essential for homeostasis function. Emerging research has unveiled significant role of extracellular vesicles (EVs) key mediators communication in regulating many aspects physiological pathological processes. In this review, we provide overview recent advances understanding roles EVs health, aging, diseases, discuss natural engineered disease treatment along potential challenges. burgeoning area may expand new therapeutic approaches disorders open avenues personalized skincare treatments.
Language: Английский
Citations
10
Regenerative Therapy, Journal Year: 2024, Volume and Issue: 26, P. 260 - 274
Published: June 1, 2024
Chronic wounds represent a significant global burden, afflicting millions with debilitating complications. Despite standard care, impaired healing persists due to factors like persistent inflammation and tissue regeneration. Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) offer an innovative regenerative medicine approach, delivering cell-derived therapeutic cargo in engineered nanoscale delivery systems. This review examines pioneering bioengineering strategies engineer MSC-EVs into precision nanotherapeutics for chronic wounds. Emerging technologies CRISPR gene editing, microfluidic manufacturing, biomimetic systems are highlighted their potential enhance MSC-EV targeting, optimize enrichment, ensure consistent clinical-grade production. However, key hurdles remain, including batch variability, rigorous safety assessment tumorigenicity, immunogenicity, biodistribution profiling. Crucially, collaborative frameworks harmonizing regulatory science patient advocacy hold the expediting clinical translation. By overcoming these challenges, could catalyze new era of off-the-shelf therapies, restoring hope afflicted by non-healing
Language: Английский
Citations
9
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Extracellular vesicles (EVs) hold promise for tissue regeneration, but their low yield and limited therapeutic efficacy hinder clinical translation. Bioreactors provide a larger culture surface area stable environment large-scale EV production, yet ability to enhance is limited. Physical stimulation, by inducing cell differentiation modulating cargo composition, offers more efficient, cost-effective, reproducible approach compared the loading of EVs biochemical priming parental cells. Herein, effects 3D-printed perfusion bioreactor with topographical cue on macrophage bioactivity were assessed. The results indicate that increased 12.5-fold enhanced in promoting osteogenic angiogenesis via upregulated miR-210-3p. Mechanistically, fluid shear stress activates Piezo1, triggering Ca2+ influx Yes-associated protein (YAP) nuclear translocation, secretion enhancing M2 polarization conjunction morphological changes guided aligned topography. Moreover, porous electrospun membrane-hydrogel composite scaffold loaded bioreactor-derived exhibited outstanding rat cranial defect model. This study presents scalable, platform production EVs, potentially overcoming key challenges translating EV-based therapies clinic.
Language: Английский
Citations
1
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2377 - 2393
Published: March 1, 2024
Abstract: Chronic kidney diseases (CKD) present a formidable global health challenge, characterized by deficiency of effective treatment options. Extracellular vesicles (EVs), recognized as multifunctional drug delivery systems in biomedicine, have gained accumulative interest. Specifically, engineered EVs emerged promising therapeutic approach for targeted delivery, potentially addressing the complexities CKD management. In this review, we systematically dissect EVs, elucidating their classification, biogenesis, composition, and cargo molecules. Furthermore, explore techniques EV engineering strategies precise renal focusing on loading transportation, providing comprehensive perspective. Moreover, review also discusses summarizes diverse applications CKD, emphasizing anti-inflammatory, immunomodulatory, renoprotective, tissue-regenerating effects. It critically evaluates challenges limitations translating therapies from laboratory settings to clinical applications, while outlining future prospects emerging trends. Keywords: extracellular vesicles, nanomaterials, chronic diseases, systems, application
Language: Английский
Citations
3
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 8815 - 8830
Published: Aug. 1, 2024
Diabetic wounds pose a significant challenge in modern healthcare due to their chronic and complex nature, often resulting delayed healing, infections, and, severe cases, amputations. In recent years, nanotherapeutic approaches have emerged as promising strategies address the unique pathophysiological characteristics of diabetic wounds. This review paper provides comprehensive overview latest advancements nanotherapeutics for wound treatment. We discuss various nanomaterials delivery systems employed these emerging therapies. Furthermore, we explore integration biomaterials enhance efficacy interventions. By examining current state-of-the-art research, challenges, prospects, this aims offer valuable insights researchers, clinicians, professionals working field care.
Language: Английский
Citations
2
Tzu Chi Medical Journal, Journal Year: 2024, Volume and Issue: unknown
Published: May 24, 2024
Extracellular vesicles (EVs) have emerged as key players in intercellular communication, disease pathology, and therapeutic innovation. Initially overlooked cellular debris, EVs are now recognized vital mediators of cell-to-cell ferrying a cargo proteins, nucleic acids, lipids, providing resilience response to stresses. This review provides comprehensive overview EVs, focusing on their role biomarkers diagnosis, functional significance physiological pathological processes, the potential bioengineering for applications. offer promising avenue noninvasive diagnosis monitoring, reflecting state originating cells. Their diagnostic spans spectrum diseases, including cancer, cardiovascular disorders, neurodegenerative infectious diseases. Moreover, presence bodily fluids such blood, urine, cerebrospinal fluid enhances utility, presenting advantages over traditional methods. Beyond diagnostics, mediate crucial roles facilitating transfer bioactive molecules between communication modulates various processes tissue regeneration, immune modulation, neuronal communication. Dysregulation EV-mediated is implicated diseases highlighting potential. Bioengineering techniques avenues manipulating applications, from isolation purification engineering targeted delivery systems. These approaches hold promise developing novel therapeutics tailored specific revolutionizing personalized medicine. However, challenges standardization, scalability, regulatory approval need addressing successful clinical translation. Overall, represent dynamic frontier biomedical research with vast therapeutics,
Language: Английский
Citations
1
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117392 - 117392
Published: Sept. 3, 2024
Sensorineural hearing loss is one of the most prevalent sensory deficits. Spiral ganglion neurons (SGNs) exhibit very limited regeneration capacity and their degeneration leads to profound loss. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEV) have been demonstrated repair tissue damage in various degenerative diseases. However, effects MSC-sEV on SGN remain unclear. In this study, we investigated efficacy for protection against ouabain-induced degeneration. were derived from rat bone marrow components related neuron growth determined by proteomic analysis. primary culture SGNs, significantly promoted neurite cone development. The RNA-Seq analysis SGNs showed that enriched pathways include development axon regeneration, consistent with proteomics. ouabain induced model, administration via intratympanic injection enhanced survival mitigated Furthermore, after treatment, displayed evident signs apoptosis, including nuclei condensation fragmentation, numerous cells exhibiting TUNEL-positive. effectively decreased number TUNEL-positive reduced caspase-3 activation. conclusion, our findings demonstrate potential preventing promoting neural growth, suggesting a specific efficient strategy
Language: Английский
Citations
0
Regenerative Therapy, Journal Year: 2024, Volume and Issue: 26, P. 1037 - 1047
Published: June 1, 2024
Language: Английский
Citations
0