Lanthanide-Doped Upconversion Luminescence: A New Frontier in Pathogenic Bacteria and Metabolite Detection from Design to Point-of-Care Application

Chemosensors, Journal Year: 2025, Volume and Issue: 13(2), P. 60 - 60

Published: Feb. 8, 2025

Pathogens and their metabolites in food present significant risks to both human health economic development. Rising living standards increasing awareness of safety have driven the demand for sensitive rapid detection methods. Lanthanide-doped upconversion nanoparticles (UCNPs), with exceptional optical properties, emerged as a promising platform developing biosensors detect pathogenic bacteria metabolites. The integration UCNPs point-of-care testing (POCT) has garnered considerable attention its portability immediacy, highlighting future biosensing, particularly applications requiring quick accurate diagnostics. This review explores recognition elements design principles commonly used UCNP-based examines various applications, including lateral flow assays, microfluidic systems, photoelectrochemical devices, smartphone-integrated platforms. Despite advancements, challenges remain applicability commercialization biosensing technology. Future research should focus on enhancing sensitivity specificity, scalable cost-effective production methods, integrating advanced digital technologies enable broader adoption. Addressing these challenges, establishing regulatory frameworks, considering sustainability will be crucial fully realizing potential biosensors.

Language: Английский

---

High‐Sensitivity Ratiometric Temperature Sensing and Information Encryption Based on Upconversion Emissions from Lanthanide Ions Doped BaTiO₃ Phosphor

Advanced Optical Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract Upconversion emissions from lanthanide ions have unparalleled advantages in the field of temperature sensing and information encryption. Despite extensive research on probes, developing highly sensitive measurement applications still poses a significant challenge. This study utilizes doped BaTiO₃ as foundational material to develop fiber optic probe with enhanced sensitivity. The optical temperature‐sensing capabilities are assessed based intensity ratio various energy levels BaTiO₃: Yb/Tm/Er phosphors. Notably, non‐thermal coupling level between Tm Er demonstrates highest sensitivity, achieving maximum relative sensitivity 2.70% K⁻¹ at 303 K. By leveraging temperature‐dependent color change material, large‐capacity photonic barcode for storage encrypted transmission is developed, thereby expanding potential monitoring.

Language: Английский

---

Advancing gastric cancer treatment: nanotechnology innovations and future prospects

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: Nov. 20, 2024

Gastric cancer (GC) is the fifth most common worldwide, particularly prevalent in Asia, especially China, where both its incidence and mortality rates are significantly high. Meanwhile, nanotechnology has demonstrated great potential treatment of GC. In particular, nanodrug delivery systems have improved therapeutic efficacy targeting through various functional modifications, such as peptides, tumor microenvironment responsiveness, instrument-based methods. For instance, silica (SiO2) excellent biocompatibility can be used a drug carrier, with porous structure enhancing loading capacity. Polymer nanoparticles regulate release mechanisms by altering material composition preparation Lipid efficiently encapsulate hydrophilic drugs promote cellular uptake, while carbon-based biosensors delivery. Targets integrins, HER2 receptors, been to improve GC treatment. Nanodrug techniques not only enhance capabilities but also selectively target cells. Currently, there lack systematic summarization synthesis regarding relationship between treatment, which some extent hinders researchers clinicians from searching for referencing related studies, thereby reducing work efficiency. This study aims systematically summarize existing research on making it easier professionals search reference, promoting further role their clinical applications review discusses functionalized nanocarriers recent years, including surface modifications targeted markers, combination phototherapy, chemotherapy, immunotherapy, along advantages challenges. It examines future prospects nanomaterials The focuses combined application multiple modalities, demonstrating multimodal treatments. Furthermore, thoroughly explores specific challenges that face biocompatibility, control, translation issues, providing outlook developments. Additionally, this emphasizes value feasibility applications, contrasting reviews focus basic research. Through these innovations, we offer new perspectives directions development

Language: Английский

---

Red/near-infrared light triggered photorelease via sensitized photolysis

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216117 - 216117

Published: July 27, 2024

Language: Английский

---

Boosted sensitive optical thermometers utilizing synergistic effects of thermal enhancement and quenching in Er/Yb/Nd triply-doped Bi4Ti3O12 nanosheets

Journal of Alloys and Compounds, Journal Year: 2024, Volume and Issue: 1005, P. 176133 - 176133

Published: Aug. 23, 2024

Language: Английский

---

Luminescent Lanthanides in Biorelated Applications: From Molecules to Nanoparticles and Diagnostic Probes to Therapeutics

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Lanthanides are particularly effective in their clinical applications magnetic resonance imaging and diagnostic assays. They have open-shell 4f electrons that give rise to characteristic narrow, line-like emission which is unique from other fluorescent probes biological systems. Lanthanide luminescence signal offers selection of detection pathways based on the choice ion visible near-infrared with long lifetimes lend themselves time-resolved measurements for optical multiplexing schemes novel bioimaging applications. The delivery lanthanide agents cells allows localized bioresponsive activity therapies. Detection region spectrum coupled technological advances microscopies opens new avenues deep-tissue surgical interventions. This review focuses different ways can be exploited nucleic acid enzyme detection, anion recognition, cellular imaging, tissue photoinduced therapeutic We focused hierarchy designs include luminescent lanthanides as biology considering coordination complexes, multimetallic systems metal-organic frameworks nanoparticles highlighting strategies downshifting, upconversion revealing some opportunities challenges offer potential further development field.

Language: Английский

---

Intrinsic Optical Response of Levitating Upconverting Single Particles

ACS Photonics, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

---

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

ABSTRACT Extracellular vesicles (EVs) are essential for host–pathogen interactions, mediating processes such as immune modulation and pathogen survival. Pathogen‐derived EVs hold significant diagnostic potential because of their unique cargo, offering a wealth biomarkers. In this review, we first discuss the roles derived from various pathogens in interactions summarize latest advancements detection based on EVs. Then, highlight innovative strategies, including novel aggregate materials machine learning approaches, enhancing EV analysis. Finally, challenges field future directions advancing EV‐based diagnostics, aiming to translate these insights into clinical applications.

Language: Английский

---

Nanomaterials-Integrated CRISPR/Cas Systems: Expanding the Toolbox for Optical Detection

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Nanomaterials-integrated CRISPR/Cas systems have rapidly emerged as powerful next-generation platforms for optical biosensing. These integrated harness the precision of CRISPR/Cas-mediated nucleic acid detection while leveraging unique properties nanomaterials to achieve enhanced sensitivity and expanded analytical capabilities, thereby broadening their diagnostic potential. By incorporating a diverse range nanomaterials, these effectively expand toolbox detection, offering adaptable solutions tailored various challenges. This review provides comprehensive overview successfully into CRISPR/Cas-based sensing systems. It examines multiple modalities, including fluorescence, electrochemiluminescence, colorimetry, surface-enhanced Raman spectroscopy, highlighting how facilitate signal amplification, enable multiplexing, support development point-of-care applications. Additionally, practical applications in critical fields such healthcare diagnostics environmental monitoring are showcased. While offer considerable advantages, several real-world challenges complexity assay workflows, impact cost, regulatory hurdles must be addressed before widespread implementation can achieved. identifying obstacles proposing strategic solutions, we aim pave way continued advancement adoption nanomaterial-integrated biosensing technologies.

Language: Английский

---

Light-Emitting Materials for Point-of-Care Diagnostics

Engineering materials, Journal Year: 2025, Volume and Issue: unknown, P. 145 - 167

Published: Jan. 1, 2025

Language: Английский

---