Ultrastable in-situ silver nanoparticle dressing for effective prevention and treatment of wound infection in emergency DOI Creative Commons
Wei Wang, Ziwei Hu,

Wanying Mo

et al.

Engineered Regeneration, Journal Year: 2024, Volume and Issue: 5(1), P. 111 - 123

Published: Jan. 14, 2024

The use of antibacterial dressings is crucial in the prevention and treatment wound infection emergency situations. However, efficacy compromised by long-term storage or exposure to harsh conditions. Here, an ultrastable in-situ silver nanoparticle dressing (AgSNP@CD) was prepared for effective emergency. fabrication process AgSNP@CD simple, suitable large-scale production. Due strong interaction between synthesized AgNPs cotton fabric, owned remarkable stability, thus retaining its antimicrobial even after (up 2 years) under extreme conditions (damp heat, low temperatures, low-oxygen, water immersion, acid-alkali erosion). Both vitro vivo results demonstrated extraordinary stability AgSNP@CD, facilitating healing In particular, exhibited a superior effect on severe bacteria-infected trauma can prevent occurrence sepsis effectively. exceptional complex make it well-suited strategy

Language: Английский

Intelligent Electrospinning Nanofibrous Membranes for Monitoring and Promotion of Wound Healing DOI Creative Commons
Zhi Qu, Yang Wang, Yanhong Dong

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101093 - 101093

Published: May 18, 2024

The incidence of chronic wound healing is promoted by the growing trend elderly population, obesity, and type II diabetes. Although numerous dressings have been studied over years, it still challenging for many to perfectly adapt process due dynamic complicated microenvironment. Aiming at an optimal reproduction physiological environment, multifunctional electrospinning nanofibrous membranes (ENMs) emerged as a promising platform treatment owing their resemblance extracellular matrix (ECM), adjustable preparation processes, porousness, good conformability site. Moreover, profiting from booming development human-machine interaction artificial intelligence, next generation intelligent (iENMs) based dressing substrates that could realize real-time monitoring proceeding individual-based therapy has evoked surge interest. In this regard, general wound-related biomarkers are overviewed firstly representative iENMs stimuli-responsive materials briefly summarized. Subsequently, emergent applications highlighted. Finally, opportunities challenges next-generation well translating into clinical practice evaluated.

Language: Английский

Citations

16
Poly(p-Phenylene Benzobisoxazole) Nanofiber: A Promising Nanoscale Building Block Toward Extremely Harsh Conditions DOI
Baolong Yuan, Bin Yang, Ping Xu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Since the invention and commercialization of poly(

Language: Английский

Citations

2
Polysaccharide Electrospun Nanofibers for Wound Healing Applications DOI Creative Commons

Guoxin Tan,

Lijie Wang, Weisan Pan

et al.

International Journal of Nanomedicine, Journal Year: 2022, Volume and Issue: Volume 17, P. 3913 - 3931

Published: Sept. 1, 2022

As a type of biological macromolecule, natural polysaccharides have been widely used in wound healing due to their low toxicity, good biocompatibility, degradability and reproducibility.Electrospinning is versatile simple technique for producing continuous nanoscale fibers from variety synthetic polymers.The application electrospun nanofibers as dressings has made great progress they are considered one the most effective dressings.This paper reviews preparation polysaccharide by electrospinning prospects field healing.A nanofibers, including chitosan, starch, alginate, hyaluronic acid introduced.The strategy functions promoting summarized.In addition, future challenges also discussed.

Language: Английский

Citations

59
Stimuli‐Responsive Electrospun Fluorescent Fibers Augmented with Aggregation‐Induced Emission (AIE) for Smart Applications DOI Creative Commons
Vishal Kachwal, Jin‐Chong Tan

Advanced Science, Journal Year: 2022, Volume and Issue: 10(1)

Published: Nov. 14, 2022

Abstract This review addresses the latest advancements in integration of aggregation‐induced emission (AIE) materials with polymer electrospinning, to accomplish fine‐scale electrospun fibers tunable photophysical and photochemical properties. Micro‐ nanoscale augmented AIE dyes (termed AIEgens) are bespoke composite systems that can overcome limitation posed by aggregation‐caused quenching, a critical deficiency conventional luminescent materials. comprises three parts. First, reader is exposed basic concepts fundamental mechanisms underpinning restriction intermolecular motions. followed an introduction electrospinning techniques pertinent AIE‐based fibers, core parameters for controlling fiber architecture resultant Second, exemplars drawn from research demonstrate how nanofibers porous films incorporating modified AIEgens (especially tetraphenylethylene triphenylamine derivatives) yield enhanced photostability, photothermal properties, photoefficiency (quantum yield), improved device sensitivity. Advanced applications several promising sectors, encompassing optoelectronics, drug delivery biology, chemosensors mechanochromic sensors, innovative devices, among others. Finally, outstanding challenges together potential opportunities nascent field AIE‐active presented, stimulating frontier explorations this exciting field.

Language: Английский

Citations

45
Flexible, robust and self-peeling PLA/AgNWs nanofiber membranes with photothermally antibacterial properties for wound dressing DOI

Yonghe Zhao,

Qinqin Lu,

Junzhi Wu

et al.

Applied Surface Science, Journal Year: 2023, Volume and Issue: 615, P. 156284 - 156284

Published: Jan. 2, 2023

Language: Английский

Citations

33
Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications DOI Creative Commons

Yamei Xu,

Qiyuan Hu,

Zongyun Wei

et al.

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Diabetic ulcers (DUs) are one of the most serious complications diabetes mellitus. The application a functional dressing is crucial step in DU treatment and associated with patient's recovery prognosis. However, traditional dressings simple structure single function cannot meet clinical requirements. Therefore, researchers have turned their attention to advanced polymer hydrogels solve therapeutic bottleneck treatment. Hydrogels class gels three-dimensional network that good moisturizing properties permeability promote autolytic debridement material exchange. Moreover, mimic natural environment extracellular matrix, providing suitable surroundings for cell proliferation. Thus, different mechanical strengths biological been extensively explored as platforms. In this review, we define types elaborate mechanisms by which they repair DUs. summarize pathological process DUs review various additives used Finally, examine limitations obstacles exist development clinically relevant applications these appealing technologies. This defines carefully diabetic (DUs), summarizes DUs, reviews bioactivators

Language: Английский

Citations

32
Oxidization enhances type I ROS generation of AIE-active zwitterionic photosensitizers for photodynamic killing of drug-resistant bacteria DOI Creative Commons
Jianye Gong,

Lingxiu Liu,

Chunbin Li

et al.

Chemical Science, Journal Year: 2023, Volume and Issue: 14(18), P. 4863 - 4871

Published: Jan. 1, 2023

Type I photosensitizers (PSs) with an aggregation-induced emission (AIE) feature have received sustained attention for their excellent theranostic performance in the treatment of clinical diseases. However, development AIE-active type PSs strong reactive oxygen species (ROS) production capacity remains a challenge due to lack in-depth theoretical studies on aggregate behavior and rational design strategies. Herein, we proposed facile oxidization strategy enhance ROS generation efficiency PSs. Two AIE luminogens, MPD its oxidized product MPD-O were synthesized. Compared MPD, zwitterionic showed higher efficiency. The introduction electron-withdrawing atoms results formation intermolecular hydrogen bonds molecular stacking MPD-O, which endowed more tightly packed arrangement state. Theoretical calculations demonstrated that accessible intersystem crossing (ISC) channels larger spin-orbit coupling (SOC) constants provide further explanation superior evidenced effectiveness enhancing ability by strategy. Moreover, DAPD-O, cationic derivative was synthesized improve antibacterial activity showing photodynamic against methicillin-resistant S. aureus both vitro vivo. This work elucidates mechanism offers new guideline exploitation

Language: Английский

Citations

28
Smart One‐for‐All Agent with Adaptive Functions for Improving Photoacoustic /Fluorescence Imaging‐Guided Photodynamic Immunotherapy DOI
Heqi Gao,

Xinwen Qi,

Jingtian Zhang

et al.

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Feb. 19, 2023

Multifunctional phototheranostics that integrate several diagnostic and therapeutic strategies into one platform hold great promise for precision medicine. However, it is really difficult molecule to possess multimodality optical imaging therapy properties all functions are in the optimized mode because absorbed photoenergy fixed. Herein, a smart one-for-all nanoagent photophysical energy transformation processes can be facilely tuned by external light stimuli developed precise multifunctional image-guided therapy. A dithienylethene-based designed synthesized has two light-switchable forms. In ring-closed form, most of dissipates via nonradiative thermal deactivation photoacoustic (PA) imaging. ring-open possesses obvious aggregation-induced emission features with excellent fluorescence photodynamic properties. vivo experiments demonstrate preoperative PA help delineate tumors high-contrast manner, intraoperative able sensitively detect tiny residual tumors. Furthermore, induce immunogenic cell death elicit antitumor immunity significantly suppress solid This work develops agent related phototheranostic light-driven structure switch, which promising biomedical applications.

Language: Английский

Citations

27
AIEgen-based smart system for fungal-infected wound monitoring and on-demand photodynamic therapy DOI Creative Commons
Kun Zhou, Siyuan Wang,

Letian Xu

et al.

Matter, Journal Year: 2023, Volume and Issue: 6(10), P. 3449 - 3462

Published: July 19, 2023

Language: Английский

Citations

25
Aggregation-induced emission biomaterials for anti-pathogen medical applications: detecting, imaging and killing DOI Creative Commons
Zicong Zhang,

Ziwei Deng,

Lixun Zhu

et al.

Regenerative Biomaterials, Journal Year: 2023, Volume and Issue: 10

Published: Jan. 1, 2023

Abstract Microbial pathogens, including bacteria, fungi and viruses, greatly threaten the global public health. For pathogen infections, early diagnosis precise treatment are essential to cut mortality rate. The emergence of aggregation-induced emission (AIE) biomaterials provides an effective promising tool for theranostics infections. In this review, recent advances about AIE anti-pathogen summarized. With excellent sensitivity photostability, have been widely applied pathogens. Besides, different types methods based on will be presented in detail, chemotherapy phototherapy. Finally, existing deficiencies future development applications discussed.

Language: Английский

Citations

23