An Immunomodulatory Hydrogel by Hyperthermia‐Assisted Self‐Cascade Glucose Depletion and ROS Scavenging for Diabetic Foot Ulcer Wound Therapeutics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(48)

Published: Oct. 7, 2023

Abstract Current therapeutic protocols for diabetic foot ulcers (DFUs), a severe and rapidly growing chronic complication in patients, remain nonspecific. Hyperglycemia‐caused inflammation excessive reactive oxygen species (ROS) are common obstacles encountered DFU wound healing, often leading to impaired recovery. These two effects reinforce each other, forming an endless loop. However, adequate inclusive methods still lacking target these aspects break the vicious cycle. This study proposes novel approach treating wounds, utilizing immunomodulatory hydrogel achieve self‐cascade glucose depletion ROS scavenging regulate microenvironment. Specifically, AuPt@melanin‐incorporated (GHM3) dressing is developed facilitate efficient hyperthermia‐enhanced local scavenging. Mechanistically, vitro/vivo experiments RNA sequencing analysis demonstrate that GHM3 disrupts ROS‐inflammation cascade cycle downregulates ratio of M1/M2 macrophages, consequently improving outcomes dorsal skin wounds rats. In conclusion, this proposed offers facile, safe, highly treatment modality DFUs.

Language: Английский

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Injectable and self-healable nano-architectured hydrogel for NIR-light responsive chemo- and photothermal bacterial eradication

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(7), P. 1905 - 1925

Published: Jan. 1, 2024

A stimuli-responsive, injectable, and in situ -forming hydrogel with synergistic, self-healing, on-demand drug-delivery antibacterial properties.

Language: Английский

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Chitosan-Based Biomaterial in Wound Healing: A Review

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 28, 2024

Wound healing is an evolving and intricate technique that vital to the restoration of tissue integrity function. Over past few decades, chitosan a biopolymer derived from chitin, became known as emerging biomaterial in field wounds due its distinctive characteristics including biocompatibility, biodegradability, affinity biomolecules, wound-healing activity. This natural polymer exhibits excellent capabilities by accelerating development new skin cells, reducing inflammation, preventing infections. Due distinct biochemical innate antibacterial activity, has been extensively researched wound dressing. Chronic wounds, such diabetic ulcers liver disease, are growing medical problem. Chitosan-based biomaterials promising solution domain care. The article analyzes depth chitosan-based their impact on also methods enhance advantages incorporating bioactive compounds. literature review aimed improve understanding knowledge about use healing.

Language: Английский

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Polymer hydrogels: Classification and recent advances

Journal of Macromolecular Science Part A, Journal Year: 2024, Volume and Issue: 61(5), P. 265 - 288

Published: March 19, 2024

Hydrogels comprise of a group crosslinked hydrophilic polymeric materials which are capable absorbing and holding large quantities water in their three-dimensional network structure without undergoing dissolution. More importantly, the ability 'smart' hydrogels to respond certain environmental changes e.g. pH, heat, light, magnetic field, biomolecules have set them apart as unique class materials. A combination several such useful properties resulted tremendous progress toward development advanced hydrogel-based materials, is evident from an explosive amount research publications available this area over last few decades. Owing particularly biocompatibility biodegradability, become material prime importance context wide range applications starting simple contact lenses more complex ones tissue repair, drug delivery, sensors, 3D bioprinting, soft robotics agriculture. This review includes i) overview its classifications based on source, structure, crosslinking mechanism stimuli responsiveness, ii) detailed discussion some most works being carried out field years smart that need hour, domain biomedical applications.

Language: Английский

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Insights of biopolymeric blended formulations for diabetic wound healing

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 656, P. 124099 - 124099

Published: April 16, 2024

Language: Английский

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Hydrogels loaded with MSC‐derived small extracellular vesicles: A novel cell‐free tissue engineering system for diabetic wound management

View, Journal Year: 2024, Volume and Issue: 5(4)

Published: July 18, 2024

Abstract With the aging and obesity era, increasing incidence of diabetes diabetic complications, especially non‐healing wounds, imposes a serious economic burden on both patients society. The complex microenvironments, including hyperglycemia, bacterial infection, ischemia, nerve damage, lead to prolonged inflammation proliferation phase wounds. Mesenchymal stem cell‐derived small extracellular vesicles (MSC‐sEVs), which contain rich variety therapeutic molecules, have been chased for decades because their potential roles in cellular communication, tissue regeneration, drug delivery. As powerful tools controlled‐sustained release sEVs, biocompatible hydrogels applied wide range biomedical applications. Herein, we first summarize pathological features such as angiopathy, neuropathy, immune cell dysfunction. Then, discuss biological properties, performance, stability pure MSC‐sEVs. After that, components, application patterns, responsiveness hydrogels. Next, loading avenues MSC‐sEVs into hydrogel, behaviors sEVs from hydrogels, influence crosslinking method hydrogel‐sEV composites. Finally, provide an overview current applications loaded with novel cell‐free engineering system managing wounds propose critical unsolved issues. This review is expected meaningful guidance developing wound management.

Language: Английский

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Biopolymer-based hydrogels for biomedical applications: Bioactivity and wound healing properties

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216093 - 216093

Published: July 25, 2024

Language: Английский

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Multifunctional and theranostic hydrogels for wound healing acceleration: An emphasis on diabetic-related chronic wounds

Environmental Research, Journal Year: 2023, Volume and Issue: 238, P. 117087 - 117087

Published: Sept. 15, 2023

Language: Английский

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Teicoplanin‐Decorated Reduced Graphene Oxide Incorporated Silk Protein Hybrid Hydrogel for Accelerating Infectious Diabetic Wound Healing and Preventing Diabetic Foot Osteomyelitis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: April 24, 2024

Developing hybrid hydrogel dressings with anti-inflammatory, antioxidant, angiogenetic, and antibiofilm activities higher bone tissue penetrability to accelerate diabetic wound healing prevent foot osteomyelitis (DFO) is highly desirable in managing wounds. Herein, the glycopeptide teicoplanin used for first time as a green reductant chemically reduce graphene oxide (GO). The resulting teicoplanin-decorated reduced (rGO) incorporated into mixture of silk proteins (SP) crosslinked genipin yield physicochemically rGO-SP hydrogel. This exhibits high porosity, self-healing, shear-induced thinning, increased cell proliferation migration, mechanical properties suitable engineering. Moreover, eradicates bacterial biofilms index agar hydroxyapatite disks covered biofilms, mimicking tissue. In vivo, accelerates noninfected wounds rat infected mouse by upregulating anti-inflammatory cytokines downregulating matrix metalloproteinase-9, promoting M2 macrophage polarization angiogenesis. implantation site tibia improves regeneration. Hence, can be promising dressing treating infectious wounds, providing further advantage preventing DFO.

Language: Английский

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Natural Polymeric Hydrogels Encapsulating Small Molecules for Diabetic Wound Healing

Gels, Journal Year: 2023, Volume and Issue: 9(11), P. 867 - 867

Published: Oct. 30, 2023

Diabetes is a condition correlated with high number of diagnosed chronic wounds as result complex pathophysiological mechanism. Diabetic are characterized by disorganized and longer stages, compared to normal wound healing. Natural polymer hydrogels can act good dressings due their versatile physicochemical properties, represented mainly water content biocompatibility. bioactive polymers loaded compounds providing antibacterial antioxidant modulation inflammation adherence wounded tissue, traditional dressings, which enables promising future applications for diabetic compounds, such polyphenols, polysaccharides proteins have great advantages in promoting healing diabetes antioxidant, anti-inflammatory, antimicrobial, anti-allergic properties. The present paper aims review the mechanisms underlining main issues those specifically occurring diabetes. Also, highlights recent state art related effect enriched natural developed biocompatible functional materials improving diabetic-related novel therapeutic strategies that could prevent limb amputation increase quality life patients.

Language: Английский

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