Journal of advanced Biomedical and Pharmaceutical Sciences,
Journal Year:
2023,
Volume and Issue:
6(4), P. 184 - 187
Published: Oct. 1, 2023
Cannabinoids
have
many
important
properties,
such
as
anti-inflammatory,
antioxidant,
and
neuroprotective
effects
that
make
cannabinoids
promising
to
reduce
kidney
liver
toxicity.There
are
some
conditions,
oxidative
stress
fibrosis,
well
inflammation,
associated
with
nephrotoxicity
hepatotoxicity.Cannabinoids
showed
the
ability
these
effects.According
numerous
experimental
investigations
preclinical
models,
compounds
appear
play
a
part
in
controlling
inflammation
cell
death
by
activating
certain
receptors
regulating
cellular
pathways.However,
assure
safety
effectiveness
of
cannabinoids,
further
research
is
required
develop
dose
regimens
comprehend
medication
interactions.Measurements
cannabinoid
optimal
dosages,
frequency,
duration
treatment
need
be
addressed
carefully.
Food & Function,
Journal Year:
2023,
Volume and Issue:
14(20), P. 9226 - 9242
Published: Jan. 1, 2023
Selenium
deficiency
cause
oxidative
stress
through
upregulation
of
miR-138-5p
targeting
SelM,
which
disrupted
Ca
2+
and
energy
metabolic
homeostasis
allowing
hepatocyte
necroptosis
leading
to
hepatitis
in
chickens.
Environmental and Molecular Mutagenesis,
Journal Year:
2023,
Volume and Issue:
64(7), P. 382 - 392
Published: July 15, 2023
Cadmium
(Cd),
a
heavy
metal,
is
used
in
wide
range
of
applications,
such
as
plastics,
electroplating
process,
electronics,
and
so
forth.
Due
to
its
bioaccumulation
ability,
Cd
can
contaminate
soil,
water,
air
food.
To
determine
the
effect
exposure
on
necroptosis
pig
spleen
mechanistic
investigation,
we
constructed
model
pigs
by
feeding
them
food
containing
20
mg/kg
Cd.
In
this
study,
analyzed
effects
through
HE
staining,
Quantitative
real-time
PCR
(qRT-PCR),
Western
blot
(WB),
principal
component
analysis
(PCA).
Results
show
that
destroy
structure
function
spleen,
which
closely
related
necroptosis.
Further
results
induce
ROS-mediated
activation
Signal
transducer
activator
transcription
1/Receptor-Interacting
Serine/Threonine-Protein
Kinase
3
(STAT1/RIPK3)
signaling
pathway
spleen.
Additionally,
also
affect
stability
mitochondrial-associated
endoplasmic
reticulum
membrane
(MAMs)
structure,
contributes
process
Our
study
provides
insights
into
physiological
toxicity
caused
exposure.
