Regenerative Biomaterials,
Journal Year:
2023,
Volume and Issue:
10
Published: Jan. 1, 2023
Cu-mediated
chemodynamic
therapy
(CDT)
has
attracted
prominent
attention
owing
to
its
advantages
of
pH
independence
and
high
efficiency
comparing
Fe-mediated
CDT,
while
the
application
Cu-based
CDT
agents
was
impeded
due
copper
consumption
caused
by
metabolism
loss
resultant
potential
toxicity.
Herein,
we
developed
a
new
copper-mediated
agent
with
extremely
low
Cu
usage
anchoring
on
cross-linked
lipoic
acid
nanoparticles
(Cu@cLAs).
After
endocytosis
into
tumor
cells,
Cu@cLAs
were
dissociated
LA
dihydrolipoic
(DHLA)
(reduced
form
LA)
released
Cu2+
Cu+
(oxidized
Cu2+),
two
redox
couples
recycled
each
other
in
cells
achieve
efficient
killing
cancer
delaying
metabolic
increasing
ROS
level
cells.
The
self-recycling
confirmed
sustained
Cu/DHLA
content
persistent
generation
process.
antitumor
study
based
MCF-7/R
nude
mice
gave
inhibitory
rate
up
77.9%
at
0.05
mg
kg-1,
first
dosage
reported
so
far
lower
than
that
normal
serum
(0.83
±
0.21
kg-1).
This
work
provides
not
only
promising
clinical
strategy
for
excessive
use
but
also
gives
clue
metal
mediated
disease
therapies
consumption.
Advanced NanoBiomed Research,
Journal Year:
2022,
Volume and Issue:
2(11)
Published: Oct. 9, 2022
Molybdenum
(Mo)
is
a
trace
dietary
element
that
essential
for
human
survival.
Several
molybdenum‐containing
enzymes
(e.g.,
aldehyde
oxidase,
xanthine
oxidase
and
sulfite
oxidase)
are
associated
with
key
metabolic
activities
in
the
body.
Molybdenum‐based
nanomaterials
(Mo‐NMs),
including
molybdenum
dichalcogenides,
oxides,
molybdenum‐based
polyoxometalates,
nanocomposites,
have
been
extensively
explored
biomedical
applications
photothermal
therapy
(PTT)
because
of
their
unique
chemical
physical
properties
as
well
excellent
biocompatibility
biodegradability.
PTT,
which
relies
on
converting
near‐infrared
(NIR)
light
energy
into
thermal
to
achieve
therapeutic
effects,
has
attracted
considerable
attention
past
decades
cancer
treatment
its
localized
trigger‐activated
effects.
In
this
review,
state‐of‐the‐art
progress
Mo‐NMs
summarized.
The
classification,
synthesis,
surface
functionalization
first
introduced.
Then
discussion
PTT
PTT‐combined
therapies
effective
focused
on.
Following
that,
toxicity
assessment
also
discussed.
Finally,
short
challenges
future
prospects
field
presented.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
33(2)
Published: Nov. 23, 2022
Abstract
Chronic
diseases
claim
millions
of
lives
every
year,
and
it
is
great
significance
to
explore
develop
advanced
drugs
improve
the
cure
rate
chronic
diseases.
Nanotheranostics
are
innovative
strategies
that
enable
integration
diagnostic
therapeutic
properties
into
a
single
nanosystem.
Despite
success
in
nanotheranostics,
their
applications
nanotheranostics
nanomedicine
still
infancy.
This
because
each
disease
has
its
corresponding
characteristic
pathological
microenvironment,
which
motivates
development
endogenous
biomarker‐responsive
nanosystems
meet
requirements
diagnosis
treatment.
Herein,
recent
progress
presented
biomedical
applications.
First,
classified
eight
subsections
according
type
diseases,
including
tumors,
cardiovascular
neurological
Wilson's
liver
kidney
diabetes
mellitus,
rheumatoid
arthritis.
In
following,
variety
intriguing
biomarkers‐responsive
briefly
elaborated,
such
as
biosensing,
diagnosis,
therapy,
combined
theranostics,
early
evaluation
therapy
effect,
etc.
Finally,
challenges
future
directions
from
research
clinical
translation
these
responsive
also
presented.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: April 20, 2023
Hepatocellular
carcinoma
(HCC),
one
of
the
most
common
cancers
worldwide,
exhibits
high
immune
heterogeneity
and
mortality.
Emerging
studies
suggest
that
copper
(Cu)
plays
a
key
role
in
cell
survival.
However,
relationship
between
Cu
tumor
development
remains
unclear.We
investigated
effects
cuproptosis-related
genes
(CRGs)
patients
with
HCC
TCGA-LIHC
(The
Cancer
Genome
Atlas-Liver
cancer,
n
=
347)
ICGC-LIRI-JP
(International
Consortium-Liver
Cancer-Riken-Japan,
203)
datasets.
Prognostic
were
identified
by
survival
analysis,
least
absolute
shrinkage
selection
operator
(Lasso)
regression
model
was
constructed
using
prognostic
two
Additionally,
we
analyzed
differentially
expressed
signal
pathway
enrichment.
We
also
evaluated
CRGs
on
infiltration
their
co-expression
checkpoint
(ICGs)
performed
validation
different
microenvironments
(TIMs).
Finally,
clinical
samples
predicted
prognosis
nomogram.A
total
59
included
for
15
significantly
influenced
datasets
identified.
Patients
grouped
risk
scores,
enrichment
analysis
suggested
immune-related
pathways
substantially
enriched
both
Tumor
revealed
PRNP
(Prion
protein),
SNCA
(Synuclein
alpha),
COX17
(Cytochrome
c
oxidase
chaperone
COX17)
may
be
closely
correlated
ICG
expression.
A
nomogram
to
predict
patients'
characteristics
scores.CRGs
regulate
targeting
TIM
ICGs.
such
as
PRNP,
SNCA,
could
promising
targets
therapy
future.
Experimental Hematology and Oncology,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: May 25, 2024
Abstract
Hematological
malignancies
(HMs)
encompass
a
diverse
group
of
blood
neoplasms
with
significant
morbidity
and
mortality.
Immunotherapy
has
emerged
as
validated
crucial
treatment
modality
for
patients
HMs.
Despite
notable
advancements
having
been
made
in
understanding
implementing
immunotherapy
HMs
over
the
past
decade,
several
challenges
persist.
These
include
immune-related
adverse
effects,
precise
biodistribution
elimination
therapeutic
antigens
vivo,
immune
tolerance
tumors,
evasion
by
tumor
cells
within
microenvironment
(TME).
Nanotechnology,
its
capacity
to
manipulate
material
properties
at
nanometer
scale,
potential
tackle
these
obstacles
revolutionize
outcomes
improving
various
aspects
such
drug
targeting
stability.
The
convergence
nanotechnology
given
rise
nano-immunotherapy,
specialized
branch
anti-tumor
therapy.
Nanotechnology
found
applications
chimeric
antigen
receptor
T
cell
(CAR-T)
therapy,
cancer
vaccines,
checkpoint
inhibitors,
other
immunotherapeutic
strategies
In
this
review,
we
delineate
recent
developments
discuss
current
field
nano-immunotherapy
HMs,
offering
novel
insights
into
nanotechnology-based
approaches
diseases.
BIO Integration,
Journal Year:
2024,
Volume and Issue:
5(1)
Published: Jan. 1, 2024
Abstract
Cancer
is
a
significant
disease
that
poses
major
threat
to
human
health.
Image-guided
cancer
therapy
refers
series
of
medical
procedures
use
imaging
technology
precisely
locate
and
treat
cancer.
Combining
the
dual
characteristics
images
functional
nanomaterial
(NM)
drug
carriers,
various
integrated
diagnosis
treatment
probes
have
been
developed
for
in
vivo
dynamic
monitoring
therapeutic
effect
evaluation
drugs
based
on
imaging.
Copper
(Cu)-based
NMs
emerged
as
valuable
products
nanotechnology
due
their
unique
physicochemical
properties,
which
are
influenced
by
factors,
such
size,
shape,
surface
properties.
In
field
imaging,
Cu-based
offer
combination
desirable
characteristics,
including
fluorescence
emission,
contrast
enhancement,
radiolabeling
stability.
These
properties
form
foundation
wide
range
modalities.
addition,
can
be
used
carrier
diagnostic
or
synergistic
multiple
modalities
realized
doping
transition
metals
into
heterostructures.
become
an
important
basis
imaging-guided
with
NMs.
this
review
we
introduce
biocompatible
image-guided
provide
overview
promising
outcomes
biomedical
research.
