Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(11), P. 5864 - 5879
Published: Oct. 8, 2024
Despite
the
advancements
in
cancer
therapy,
delivering
active
pharmaceutical
ingredients
(APIs)
using
nanoparticles
remains
challenging
due
to
failed
conveyance
of
required
drug
payload,
poor
targeting
ability,
and
biodistribution,
hampering
their
clinical
translation.
Recently,
appropriate
design
materials
with
intrinsic
therapeutic
functionalities
has
garnered
enormous
interest
development
various
intelligent
nanoplatforms.
In
this
study,
we
demonstrate
fabrication
transition
metal
(molybdenum,
Mo)-doped
manganese
dioxide
(MnO2)
nanoarchitectures,
exhibiting
diagnostic
(magnetic
resonance
imaging,
MRI)
(chemodynamic
CDT)
functionalities.
The
facile
hydrothermal
approach-assisted
Mo-doped
MnO2
flower-like
nanostructures
offered
tailorable
morphologies
altered
dimensions,
precise
effects,
exceptional
biocompatibility,
biodegradability
tumor
microenvironment.
resultant
defects
doped
Mo
species
exhibited
peroxidase
oxidase
activities,
improving
glutathione
(GSH)
oxidation.
two
sets
variable
valence
ion
pairs
(Mn2+/Mn4+
Mo5+/Mo6+)
interplay
could
substantially
improve
Fenton-like
reaction
generate
toxic
hydroxyl
radicals
(•OH),
thus
achieving
CDT-assisted
antitumor
effects.
As
inherent
T1-MRI
agents,
these
displayed
excellent
MRI
efficacy
vitro.
Together,
believe
that
conformational
nanoarchitectures
states
potentiate
drugless
therapy
pharmaceutics.
Theranostics,
Journal Year:
2023,
Volume and Issue:
13(6), P. 1974 - 2014
Published: Jan. 1, 2023
Chemodynamic
therapy
(CDT)
is
well-known
for
using
the
tumor
microenvironment
to
activate
Fenton
reaction
or
Fenton-like
generate
strong
oxidative
hydroxyl
radicals
tumor-specific
treatment.
It
highly
selective
and
safe,
without
depth
limitation
of
tissue
penetration,
shows
its
potential
as
a
new
green
therapeutic
method
with
great
clinical
application.
However,
catalytic
efficiency
reagents
involved
in
severely
affected
by
inherent
microenvironmental
limitations
tumors
strict
reaction-dependent
conditions.
With
increasing
application
nanotechnology
medical
field,
combined
therapies
based
on
different
types
functional
nanomaterials
have
opened
up
avenues
development
next-generation
CDT-enhanced
system.
This
review
will
comprehensively
exemplify
representative
results
CDT
other
antitumor
such
chemotherapy,
phototherapy,
sonodynamic
therapy,
radiation
magnetic
hyperthermia
immunotherapy,
starvation
gas
gene
oncosis
combination
thereof
improving
from
hundreds
latest
literature,
introduce
strategies
ingenious
design
nanomedicines
regulations
enhance
further
summarize
challenges
future
perspective
CDT-based
multimodal
anticancer
therapy.
Small Methods,
Journal Year:
2024,
Volume and Issue:
8(8)
Published: Jan. 9, 2024
Abstract
Oxygen
(O
2
),
nitric
oxide
(NO),
carbon
monoxide
(CO),
hydrogen
sulfide
(H
S),
and
)
with
direct
effects,
dioxide
(CO
complementary
effects
on
the
condition
of
various
diseases
are
known
as
therapeutic
gases.
The
targeted
delivery
in
situ
generation
these
gases
controllable
release
at
site
disease
has
attracted
attention
to
avoid
risk
gas
poisoning
improve
their
performance
treating
such
cancer
therapy,
cardiovascular
bone
tissue
engineering,
wound
healing.
Stimuli‐responsive
gas‐generating
sources
systems
based
biomaterials
that
enable
on‐demand
promising
approaches
for
precise
therapy.
This
work
highlights
current
advances
design
development
new
generate
deliver
behavior.
delivered
biomedical
applications
is
then
discussed.
Nanoscale,
Journal Year:
2023,
Volume and Issue:
15(29), P. 12137 - 12156
Published: Jan. 1, 2023
Nanozymes
are
nanomaterials
with
catalytic
properties
similar
to
those
of
natural
enzymes,
and
they
have
recently
been
collectively
identified
as
a
class
innovative
artificial
enzymes.
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 13, 2024
Abstract
Cascade
reactions
are
described
as
efficient
and
versatile
tools,
organized
catalytic
cascades
can
significantly
improve
the
efficiency
of
chemical
interworking
between
nanozymes.
They
have
attracted
great
interest
in
many
fields
such
chromogenic
detection,
biosensing,
tumor
diagnosis,
therapy.
However,
how
to
selectively
kill
cells
by
enzymatic
without
harming
normal
cells,
well
exploring
two
or
more
enzyme‐engineered
nanoreactors
for
cascading
reactions,
remain
challenges
field
targeted
specific
cancer
diagnostics
The
latest
research
advances
nanozyme‐catalyzed
cascade
processes
diagnosis
therapy
this
article.
Here,
various
sensing
strategies
summarized,
tumor‐specific
diagnostics.
Targeting
mechanisms
treatment
using
nanozymes
classified
analyzed,
“elements”
“dimensions”
nanozymes,
types,
designs
structure,
assembly
modes
highly
active
a
variety
new
targeting
based
on
reaction
Finally,
integrated
application
systems
tumor‐targeted
diagnostic
is
which
will
lay
foundation
design
rational,
efficient,
therapeutic
modalities
future.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(22)
Published: May 16, 2024
Abstract
Chemodynamic
therapy
(CDT)
has
emerged
as
a
transformative
paradigm
in
the
realm
of
reactive
oxygen
species
‐mediated
cancer
therapies,
exhibiting
its
potential
sophisticated
strategy
for
precise
and
effective
tumor
treatment.
CDT
primarily
relies
on
metal
ions
hydrogen
peroxide
to
initiate
Fenton
or
Fenton‐like
reactions,
generating
cytotoxic
hydroxyl
radicals.
Its
notable
advantages
treatment
are
demonstrated,
including
specificity,
autonomy
from
external
triggers,
favorable
side‐effect
profile.
Recent
advancements
nanomedicine
devoted
enhancing
CDT,
promising
comprehensive
optimization
efficacy.
This
review
systematically
elucidates
cutting‐edge
achievements
chemodynamic
nanotherapeutics,
exploring
strategies
enhanced
improved
microenvironment
modulation,
regulation
energy
metabolism.
Moreover,
detailed
analysis
diverse
CDT‐mediated
combination
therapies
is
provided.
Finally,
concludes
with
discussion
prospects
intrinsic
challenges
application
nanotherapeutics
domain
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
483, P. 149040 - 149040
Published: Jan. 23, 2024
Among
metal-based
nanomaterials,
Copper-based
nanomaterials
(Cu-BNMs)
have
become
a
research
hotspot
in
the
biomedical
field
due
to
their
good
biocompatibility
and
unique
properties.
However,
there
are
fewer
systematic
summaries
of
copper-based
especially
synthesis
Cu-BNMs.
As
for
applications,
Cu-BNMs
been
widely
used
fields
antimicrobial,
imaging,
therapeutics,
showing
excellent
promising
Herein,
this
review
firstly
introduces
classification
various
methods
synthesizing
through
both
top-down
bottom-up
types.
Then,
applications
within
three
tumor
therapy
classified
summarized.
Finally,
challenges
faced
application
future
development
c
discussed
provide
basic
information
illustrations
