Altered Choroid Plexus Volume and Association with Migraine Pathophysiology DOI Creative Commons

Jianmei Xiong,

Mengqi Liu,

Huanbo Liu

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 4, 2023

Abstract Background Although compelling evidences suggest that cortical spreading depression and the trigeminovascular system activation are main mechanisms underlying migraigenesis, it remains “a nearly complete mystery of how migraine starts”. Direct evidence choroid plexus structures involved in presumed peripheral-central interaction is exceptionally scarce and, thus, which demands further attention. Objectives Our objective to assess volumetric changes quantitatively episodic chronic patients versus age sex compared normal controls, elucidate pathophysiology. Methods Total sixty-five participants including 18 patients, 16 31 controls were recruited underwent a brain MR examination with 3.0T strength between September 2021 May 2023. The ventricles was segmented fully automatically on T1-weighted MRI sequences using FreeSurfer (Version 5.3.0) software. Lateral ventricular volume expressed as ratio ipsilateral lateral ventricle (CP/LV). Group differences assessed cross-sectionally. accuracy CP/LV for prediction receiver operating characteristic curves analysis. Results Patients more anxious depressive, heavier headache burden impaired cognitive ability. Statistical analysis revealed group right side. ration decreased but size increased prolongation disease duration. side able differentiate from area under ROC curve (AUC) 0.696 (95% CI: 0.550–0.818, sensitivity 100%, specificity 46.8%, cut-off value 0.0741, P < 0.05). diagnostic efficacy marginally higher distinguishing AUC 0.715(95% 0.536–0.856, 50%, 94.4% 0.0725, Conclusion finding suggested dynamic alteration pathogenesis migraine. associated can be used potential imaging biomarker diagnosis.

Language: Английский

Human cerebellar organoids with functional Purkinje cells DOI Creative Commons
Alexander Atamian, Marcella Birtele, Negar Hosseini

et al.

Cell stem cell, Journal Year: 2024, Volume and Issue: 31(1), P. 39 - 51.e6

Published: Jan. 1, 2024

Language: Английский

Citations

39
Choroid plexus volume as a novel candidate neuroimaging marker of the Alzheimer’s continuum DOI Creative Commons
Jiwei Jiang,

Zhizheng Zhuo,

Anxin Wang

et al.

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: July 3, 2024

Enlarged choroid plexus (ChP) volume has been reported in patients with Alzheimer's disease (AD) and inversely correlated cognitive performance. However, its clinical diagnostic predictive value, mechanisms by which ChP impacts the AD continuum remain unclear.

Language: Английский

Citations

9
Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma DOI Creative Commons

Abhirami Visvanathan,

Olivier Saulnier, Chuan Chen

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(17), P. 4733 - 4750.e26

Published: July 5, 2024

We identify a population of Protogenin-positive (PRTG

Language: Английский

Citations

9
Formation and function of multiciliated cells DOI Creative Commons
Qian Lyu, Qingchao Li, Jun Zhou

et al.

The Journal of Cell Biology, Journal Year: 2023, Volume and Issue: 223(1)

Published: Nov. 30, 2023

In vertebrates, multiciliated cells (MCCs) are terminally differentiated that line the airway tracts, brain ventricles, and reproductive ducts. Each MCC contains dozens to hundreds of motile cilia beat in a synchronized manner drive fluid flow across epithelia, dysfunction which is associated with group human diseases referred as ciliopathies, such primary dyskinesia. Given dynamic complex process multiciliogenesis, biological events essential for forming multiple comparatively unelucidated. Thanks advancements genetic tools, omics technologies, structural biology, significant progress has been achieved past decade understanding molecular mechanism underlying regulation formation. this review, we discuss recent studies ex vivo culture animal models, summarize current knowledge particularly highlight advances their implications.

Language: Английский

Citations

23
Microglia innate immune response contributes to the antiviral defense and blood–CSF barrier function in human choroid plexus organoids during HSV‐1 infection DOI Creative Commons

Haowen Qiao,

Yuanpu Chiu,

Xinyan Liang

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(2)

Published: Jan. 6, 2023

Abstract The choroid plexus (ChP) is the source of cerebrospinal fluid (CSF). ChP–CSF system not only provides necessary cushion for brain but also works as a sink waste clearance. During sepsis, pathogens and host immune cells can weaken ChP barrier enter brain, causing cerebral dysfunctions known sepsis‐associated encephalophagy. Here, we used human organoid (ChPO) to model herpes simplex virus type 1 (HSV‐1) infection found epithelial were highly susceptible HSV‐1. Since current ChPO lacks functional innate component, particularly microglia, next developed new microglia‐containing model, microglia could effectively limit HSV‐1 protect in ChPOs. Furthermore, cyclic GMP‐AMP synthase (cGAS)–STING pathway its downstream interferon response essential, cGAS inhibitor RU.512 or STING H‐151 abolished antiviral function worsened organoids. These results together indicated that cGAS–STING coordinates contributes treating sepsis related neurological conditions.

Language: Английский

Citations

17
IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions DOI Open Access

Anton Shkundin,

Angelos Halaris

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(5), P. 488 - 488

Published: May 3, 2024

Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological psychiatric health. It exerts a profound effect on immune cell activation brain function, suggesting potential roles in both neuroprotection neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation disease progression. Additionally, CXCL8 gene polymorphisms can alter production, leading differences susceptibility, progression, severity across populations. levels vary among neuropsychiatric conditions, demonstrating sensitivity psychosocial stressors severity. be detected blood circulation, cerebrospinal fluid (CSF), urine, making it promising candidate for broad-spectrum biomarker. This review highlights the need further research diverse effects of associated implications personalized medicine. A thorough understanding its complex role could lead development more effective treatment strategies conditions.

Language: Английский

Citations

7
Engineering choroid plexus-on-a-chip with oscillatory flow for modeling brain metastasis DOI Creative Commons
Jungeun Lim, Stephen Rhee,

Hyeri Choi

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 22, P. 100773 - 100773

Published: Aug. 19, 2023

The human brain choroid plexus (ChP) is a highly organized secretory tissue with complex vascular system and epithelial layers in the ventricles of brain. ChP body's principal source cerebrospinal fluid (CSF); it also functions as barrier to separate blood from CSF, because movement CSF through body pulsatile nature. Thus far, has been challenging recreate specialized features dynamics physiologically relevant microenvironment. In this study, we recapitulated structure by developing microfluidic chip accordance established design rules. Furthermore, used image processing analysis mimic flow within rlcking system; hydrogel containing laminin extracellular matrix (ECM). Human cells were cultured ChP-on-a-chip vivo-like dynamic an engineered ECM. key characteristics capillaries, layer, secreted components recreated adjusted microenvironment our ChP-on-a-chip. drug screening capabilities device observed responses breast cancer that had spread ChP. immune device, demonstrated motility cytotoxic effects macrophages, which are most prevalent Our will facilitate elucidation pathophysiology support development therapeutics treat cancers have metastasized into

Language: Английский

Citations

15
A Review of Cerebrospinal Fluid Circulation and the Pathogenesis of Congenital Hydrocephalus DOI Creative Commons
Mingzhao Zhang,

Xiangjun Hu,

Lifeng Wang

et al.

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(5), P. 1123 - 1136

Published: Feb. 10, 2024

Abstract The brain’s ventricles are filled with a colorless fluid known as cerebrospinal (CSF). When there is an excessive accumulation of CSF in the ventricles, it can result high intracranial pressure, ventricular enlargement, and compression surrounding brain tissue, leading to potential damage. This condition referred hydrocephalus. Hydrocephalus classified into two categories: congenital acquired. Congenital hydrocephalus (CH) poses significant challenges for affected children their families, particularly resource-poor countries. Recognizing psychological economic impacts crucial developing interventions support systems that help alleviate distress burden faced by these families. As our understanding production circulation improves, we gaining clearer insights causes CH. In this article, will summarize current knowledge regarding pathways underlying main CH include abnormalities FoxJ1 pathway cilia, dysfunctions choroid plexus transporter Na + -K -2Cl - contransporter isoform 1, developmental cerebral cortex, structural within brain. Understanding indeed advancing research effective treatment strategies. review, findings from existing studies on propose directions further condition.

Language: Английский

Citations

5
Aberrant choroid plexus formation drives the development of treatment-related brain toxicity DOI Creative Commons
Tamara Bender,

Esther Schickel,

Celine Schielke

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 22, 2025

Abstract Brain tumors are commonly treated with radiotherapy, but the efficacy of treatment is limited by its toxicity to normal tissue including post-irradiation contrast enhanced lesions often linked necrosis. The poorly understood mechanisms behind such brain were studied using cerebral organoids. Here we show that irradiation organoids leads dose-dependent growth retardation and formation liquid-filled cavities not correlated Instead, radiation-induced changes comprise an enhancement cortical hem markers, altered neuroepithelial stem cell differentiation, increase ZO1 + /AQP1 /CLDN3 -choroid plexus (CP)-like structures accompanied upregulation IGF2 mRNA, known be expressed in CP cerebrospinal fluid. differentiation attributed WNT/BMP signaling pathways. We conclude aberrant can involved providing additional strategies for possible countermeasures.

Language: Английский

Citations

0
Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks DOI Creative Commons
Ivana Kawiková, Václav Špička,

James C. K. Lai

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

The critical role of the immune system in brain function and dysfunction is well recognized, yet development therapies for psychiatric diseases has been slow due to concerns about iatrogenic deficiencies. These are emphasized by lack objective diagnostic tools psychiatry. A promise resolve this conundrum lies exploitation extracellular vesicles (EVs) that physiologically produced or can be synthetized. EVs regulate recipient cell functions offer potential EVs-based therapies. Intranasal administration enables targeting specific regions functions, thereby facilitating design precise treatments diseases. such requires navigating four dynamically interacting networks: neuronal, glial, immune, EVs. networks profoundly influenced fluid distribution. They crucial homeostasis, cellular intercellular communication. Fluid abnormalities, like edema altered cerebrospinal (CSF) dynamics, disrupt these networks, negatively impacting health. deeper understanding above-mentioned vital creating biomarker panels identify distinct patient subsets with similar neuro-behavioral symptoms. Testing functional pathways biomarkers could lead new therapeutic tools. Regulatory approval will depend on robust preclinical data reflecting progress interdisciplinary areas, which pave way innovative treatments. Highly collaborative teams needed achieve ambitious goals.

Language: Английский

Citations

0