Role of long non-coding RNAs in neurofibromatosis and Schwannomatosis: pathogenesis and therapeutic potential DOI
Md Sadique Hussain, Somya Sharma,

Alka Kumari

et al.

Epigenomics, Journal Year: 2024, Volume and Issue: 16(23-24), P. 1453 - 1464

Published: Nov. 27, 2024

Neurofibromatosis (NF) is identified as genetic disorder characterized by multiple tumors on nerve tissues. NF1 the most prevalent form, neurofibromas and skin changes. neurofibromatosis disorder, distinct from rarer NF2 schwannomatosis (SWN) conditions. NF2, including NF2-related SWN (NF2-SWN), predominantly involves schwannoma formation differs

Language: Английский

Versatile function of NF-ĸB in inflammation and cancer DOI Creative Commons
Qiang Ma, Shuai Hao, Weilong Hong

et al.

Experimental Hematology and Oncology, Journal Year: 2024, Volume and Issue: 13(1)

Published: July 16, 2024

Abstract Nuclear factor-kappaB (NF-ĸB) plays a crucial role in both innate and adaptive immune systems, significantly influencing various physiological processes such as cell proliferation, migration, differentiation, survival, stemness. The function of NF-ĸB cancer progression response to chemotherapy has gained increasing attention. This review highlights the inflammation control, biological mechanisms, therapeutic implications treatment. is instrumental altering release inflammatory factors TNF-α, IL-6, IL-1β, which are key regulation carcinogenesis. Specifically, conditions including colitis, upregulation can intensify inflammation, potentially leading development colorectal cancer. Its pivotal extends regulating tumor microenvironment, impacting components macrophages, fibroblasts, T cells, natural killer cells. influences tumorigenesis dampen anti-tumor responses. Additionally, modulates death notably by inhibiting apoptosis ferroptosis. It also dual stimulating or suppressing autophagy cancers. Beyond these functions, controlling stem fostering angiogenesis, metastatic potential through EMT induction, reducing sensitivity radiotherapy. Given its oncogenic capabilities, research focused on products small molecule compounds that suppress NF-ĸB, offering promising avenues for therapy.

Language: Английский

Citations

25
Contribution of tumor microenvironment (TME) to tumor apoptosis, angiogenesis, metastasis, and drug resistance DOI
Yanhong Xiao, M Hassani,

Melina Barahouei Moghaddam

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 14, 2025

Language: Английский

Citations

3
Metastasis and chemoresistance in breast cancer: Crucial function of ZEB1/2 proteins DOI

Seyed Mohammad Doodmani,

Majid Safari, Mohammadarian Akbari

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 267, P. 155838 - 155838

Published: Feb. 11, 2025

Language: Английский

Citations

2
Connecting the Dots: LncRNAs in the KRAS Pathway and Cancer DOI
Mudasir Maqbool, Md Sadique Hussain, Ajay Singh Bisht

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 262, P. 155570 - 155570

Published: Aug. 29, 2024

Language: Английский

Citations

10
Non-coding RNAs as mediators of epithelial - Mesenchymal transition (EMT) in metastatic colorectal cancers DOI

Aisha Shigna Nadukkandy,

Britny Blaize,

C. Selvaa Kumar

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: 127, P. 111605 - 111605

Published: Jan. 20, 2025

Language: Английский

Citations

1
Exploring the relationship between anastasis and mitochondrial ROS-mediated ferroptosis in metastatic chemoresistant cancers: a call for investigation DOI Creative Commons
Yu Cao, Chang Lu, Narasimha M. Beeraka

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 2, 2024

Ferroptosis induces significant changes in mitochondrial morphology, including membrane condensation, volume reduction, cristae alteration, and outer rupture, affecting function cellular fate. Recent reports have described the intrinsic iron metabolism its intricate connection to ferroptosis, a kind of cell death characterized by dependence oxidative stress regulation. Furthermore, updated molecular insights elucidated significance mitochondria ferroptosis implications various cancers. In context cancer therapy, understanding dual role anastasis chemoresistance is crucial. Targeting pathways involved may enhance efficacy inducers, providing synergistic approach overcome chemoresistance. Research into how DNA damage response (DDR) proteins, metabolic changes, redox states interact during can offer new designing combinatorial therapeutic regimens against several cancers associated with stemness. These treatments could potentially inhibit while simultaneously inducing thereby reducing likelihood cells evading developing resistance chemotherapy. The objective this study explore interplay between anastasis, EMT chemoresistance, immunotherapeutics better understand their collective impact on therapy outcomes. We searched public research databases google scholar, PubMed, relemed, national library medicine related topic. review, we discussed tricarboxylic acid cycle glycolysis implicated modulating adding complexity regulatory mechanisms. Additionally, reactive oxygen species (ROS) electron transport chain (ETC) has garnered attention. Lipid metabolism, particularly involving GPX4 System Xc- plays both progression cancer. There need investigate clinical Integrating strategies targeting exploring potential synergy immunotherapy represent promising avenues for advancing chemoresistant treatment. Understanding among mitochondria, ROS, vital oncology, revolutionizing personalized treatment drug development.

Language: Английский

Citations

8
Dual role of Nrf2 signaling in hepatocellular carcinoma: promoting development, immune evasion, and therapeutic challenges DOI Creative Commons

Lin Gan,

Weimin Wang,

Jinxiu Jiang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 2, 2024

Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and ranks as third leading cause cancer-related mortality globally. The performs a wide range tasks primary organ responsible for metabolizing harmful substances foreign compounds. Oxidative stress has crucial role in growth improvement hepatocellular (HCC). Nuclear factor erythroid 2 ( 1 )-related (Nrf2) an element that regulates transcription located cytoplasm. It controls balance redox reactions by stimulating expression many genes depend on antioxidant response elements. Nrf2 contrasting functions normal, healthy HCC. In normal liver, provides advantageous benefits, while HCC it promotes effects support survival Continuous activation been detected its advancement aggressiveness. addition, Activation may lead to immune evasion, weakening cells’ ability attack tumors thereby promoting tumor development. Furthermore, chemoresistance HCC, which considered chemotherapy medications, significantly impedes effectiveness treatment. Stress management typically accomplished activating specific signal pathways chemical variables. One important creation nuclear factor-E2-related (Nrf2). production group encode proteins protecting cells from damage. This occurs through Nrf2/ARE pathway, mechanism combating oxidative within cells.

Language: Английский

Citations

5
Harnessing the synergy of nanosecond high-power microwave pulses and cisplatin to increase the induction of apoptosis in cancer cells through the activation of ATR/ATM and intrinsic pathways DOI
Juie Nahushkumar Rana, Sohail Mumtaz, Ihn Han

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

5
Multi-Drug Resistance and Breast Cancer Progression via Toll-Like Receptors (TLRs) Signaling DOI

Harikumar Pallathadka,

Abdulrahman Qais Khaleel,

Ahmed Hussein Zwamel

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(4), P. 3015 - 3030

Published: Aug. 7, 2024

Language: Английский

Citations

4
MicroRNA-21 (miR-21) in Breast Cancer: From Apoptosis Dysregulation to Therapeutic Opportunities DOI
Rahamat Unissa Syed,

Humera Banu,

Alia Alshammrani

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 262, P. 155572 - 155572

Published: Aug. 30, 2024

Language: Английский

Citations

4