Communications Biology,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Feb. 24, 2024
Abstract
Crosstalk
between
central
nervous
system
(CNS)
and
systemic
responses
is
important
in
many
pathological
conditions,
including
stroke,
neurodegeneration,
schizophrenia,
epilepsy,
etc.
Accumulating
evidence
suggest
that
signals
for
central-systemic
crosstalk
may
utilize
glymphatic
lymphatic
pathways.
The
functionally
connected
to
the
meningeal
system,
together
these
pathways
be
involved
distribution
of
soluble
proteins
clearance
metabolites
waste
products
from
CNS.
Lymphatic
vessels
dura
meninges
transport
cerebrospinal
fluid,
part
collected
cervical
lymph
nodes,
where
solutes
coming
brain
(i.e.,
VEGFC,
oligomeric
α-syn,
β-amyloid)
might
activate
a
inflammatory
response.
There
also
an
element
time
since
immune
strongly
regulated
by
circadian
rhythms,
both
dynamics
have
been
shown
change
during
day
night.
Understanding
mechanisms
regulating
brain-cervical
node
(CLN)
signaling
how
it
affected
diurnal
or
rhythms
fundamental
find
specific
targets
timing
therapeutic
interventions.
PLoS Biology,
Journal Year:
2022,
Volume and Issue:
20(3), P. e3001567 - e3001567
Published: March 24, 2022
The
circadian
clock
is
an
evolutionarily
highly
conserved
endogenous
timing
program
that
structures
physiology
and
behavior
according
to
the
time
of
day.
Disruption
rhythms
associated
with
many
common
pathologies.
emerging
field
medicine
aims
exploit
mechanisms
clock–disease
interaction
for
clinical
diagnosis,
treatment,
prevention.
In
this
Essay,
we
outline
principle
approaches
medicine,
highlight
development
in
selected
areas,
point
out
open
questions
challenges.
Circadian
has
unambiguous
health
benefits
over
standard
care
but
rarely
utilized.
It
biology
become
integrated
part
translational
research.
Diabetes Care,
Journal Year:
2024,
Volume and Issue:
47(5), P. 890 - 897
Published: April 9, 2024
To
assess
the
association
between
timing
of
aerobic
moderate
to
vigorous
physical
activity
(MVPA)
and
risk
cardiovascular
disease
(CVD),
microvascular
(MVD),
all-cause
mortality
in
adults
with
obesity
a
subset
type
2
diabetes
(T2D).
Nutrients,
Journal Year:
2020,
Volume and Issue:
12(11), P. 3228 - 3228
Published: Oct. 22, 2020
Individuals
with
type
2
diabetes
(T2D)
require
a
long-term
dietary
strategy
for
blood
glucose
management
and
may
benefit
from
time-restricted
eating
(TRE,
where
the
duration
between
first
last
energy
intake
is
restricted
to
8–10
h/day).
We
aimed
determine
feasibility
of
TRE
individuals
T2D.
Participants
T2D
(HbA1c
>6.5
<9%,
window
>12
h/day)
were
recruited
pre-post,
non-randomised
intervention
consisting
2-week
Habitual
period
establish
baseline
intake,
followed
by
4-weeks
during
which
they
instructed
limit
all
occasions
10:00
19:00
h
on
as
many
days
each
week
possible.
Recruitment,
retention,
acceptability,
safety
recorded
throughout
study
indicators
feasibility.
Dietary
glycaemic
control,
psychological
well-being,
cognitive
outcomes,
physiological
measures
explored
secondary
outcomes.
From
594
interested
persons,
27
eligible
individuals,
24
participants
enrolled
19
(mean
±
SD;
age:
50
9
years,
BMI:
34
5
kg/m2,
HbA1c:
7.6
1.1%)
completed
6-week
study.
Overall
daily
did
not
change
(~8400
kJ/d;
35%
carbohydrate,
20%
protein,
41%
fat,
1%
alcohol)
periods
(~8500
19%
42%
alcohol).
Compliance
was
72
24%
28
(i.e.,
~5
days/week),
varied
adherence
(range:
4–100%).
Comparisons
adherent
vs.
non-adherent
showed
that
9-h
reduced
through
lower
absolute
carbohydrate
alcohol
intakes.
Overall,
significantly
improve
control
−0.2
0.4%;
p
=
0.053)
or
reduce
body
mass.
impair
variable
effects
function.
described
hunger,
stressors,
emotions
main
barriers
adherence.
demonstrate
feasible
achievable
these
adhere
at
least
days/week.
The
degree
strongly
influenced
intake.
Future
trials
supporting
incorporate
in
regular
life
overcome
