Pharmacological functions of salidroside in renal diseases: facts and perspectives DOI Creative Commons
Qiong Liu, Jianzhu Chen,

Anqi Zeng

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Rhodiola rosea is a valuable functional medicinal plant widely utilized in China and other Asian countries for its anti-fatigue, anti-aging, altitude sickness prevention properties. Salidroside, most active constituent derived from , exhibits potent antioxidative, hypoxia-resistant, anti-inflammatory, anticancer, anti-aging effects that have garnered significant attention. The appreciation of the pharmacological role salidroside has burgeoned over last decade, making it beneficial option treatment multiple diseases, including atherosclerosis, Alzheimer’s disease, Parkinson’s cardiovascular more. With renoprotective effects, parallel with inhibition oxidative stress inflammation, holds promise as potential therapeutic agent kidney damage. This article provides an overview microinflammatory state disease discuss current strategies, particular focus on highlighting recent advancements utilizing renal disease. mechanisms action are primarily associated regulation gene protein expression glomerular endothelial cells, podocytes, tubule mesangial cells cell carcinoma cell, TNF-α, TGF-β, IL-1β, IL-17A, IL-6, MCP-1, Bcl-2, VEGF, ECM protein, caspase-3, HIF-1α, BIM, well modulation AMPK/SIRT1, Nrf2/HO-1, Sirt1/PGC-1α, ROS/Src/Cav-1, Akt/GSK-3β, TXNIP-NLRP3, ERK1/2, TGF-β1/Smad2/3, PI3K/Akt, Wnt1/Wnt3a β-catenin, TLR4/NF-κB, MAPK, JAK2/STAT3, SIRT1/Nrf2 pathways. To best our knowledge, this review first to comprehensively cover protective diverse suggests great be developed drug metabolic syndrome, cerebrovascular diseases complications.

Language: Английский

Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties DOI

Chenxi Tu,

Huidan Lu,

Tong Zhou

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 286, P. 121597 - 121597

Published: May 22, 2022

Language: Английский

Citations

375
Diabetic vascular diseases: molecular mechanisms and therapeutic strategies DOI Creative Commons

Yiwen Li,

Yanfei Liu, Shiwei Liu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: April 10, 2023

Abstract Vascular complications of diabetes pose a severe threat to human health. Prevention and treatment protocols based on single vascular complication are no longer suitable for the long-term management patients with diabetes. Diabetic panvascular disease (DPD) is clinical syndrome in which vessels various sizes, including macrovessels microvessels cardiac, cerebral, renal, ophthalmic, peripheral systems diabetes, develop atherosclerosis as common pathology. Pathological manifestations DPDs usually manifest macrovascular atherosclerosis, well microvascular endothelial function impairment, basement membrane thickening, microthrombosis. Cardiac, microangiopathy coexist microangiopathy, while renal retinal predominantly microangiopathic. The following associations exist between DPDs: numerous similar molecular mechanisms, risk-predictive relationships diseases. Aggressive glycemic control combined early comprehensive intervention key prevention treatment. In addition widely recommended metformin, glucagon-like peptide-1 agonist, sodium-glucose cotransporter-2 inhibitors, latest aldose reductase peroxisome proliferator-activated receptor-γ agonizts, glucokinases mitochondrial energy modulators, etc. under active development. proposed obtain more systematic care requires center focusing This would leverage advantages cross-disciplinary approach achieve better integration pathogenesis therapeutic evidence. Such strategy confer benefits promote development DPD discipline.

Language: Английский

Citations

269
The crucial role and mechanism of insulin resistance in metabolic disease DOI Creative Commons
Xuefei Zhao, Xuedong An,

Cunqing Yang

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: March 28, 2023

Insulin resistance (IR) plays a crucial role in the development and progression of metabolism-related diseases such as diabetes, hypertension, tumors, nonalcoholic fatty liver disease, provides basis for common understanding these chronic diseases. In this study, we provide systematic review causes, mechanisms, treatments IR. The pathogenesis IR depends on genetics, obesity, age, drug effects. Mechanistically, any factor leading to abnormalities insulin signaling pathway leads host, including receptor abnormalities, disturbances internal environment (regarding inflammation, hypoxia, lipotoxicity, immunity), metabolic function organelles, other abnormalities. available therapeutic strategies are mainly exercise dietary habit improvement, chemotherapy based biguanides glucagon-like peptide-1, traditional Chinese medicine (e.g., herbs acupuncture) can also be helpful. Based current there still some vacancies follow up consider, is need define more precise biomarkers different lifestyle interventions, explore natural or synthetic drugs targeting treatment. This could enable treatment patients with multiple combined diseases, aim treating disease holistically reduce healthcare expenditures improve quality life extent.

Language: Английский

Citations

222
Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine DOI Creative Commons

Fang Huang,

Xiangyu Lu, Yan Yang

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 10(2)

Published: Nov. 24, 2022

Diabetic foot ulcers (DFU), one of the most serious complications diabetes, are essentially chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial infection. Given its pathogenesis, DFU microenvironment is rather complicated characterized hyperglycemia, ischemia, hypoxia, hyperinflammation, persistent However, current clinical therapies for dissatisfactory, which drives researchers to turn attention advanced nanotechnology address therapeutic bottlenecks. In last decade, a large number multifunctional nanosystems based on have been developed with positive effects in therapy, forming novel concept "DFU nanomedicine". systematic overview nanomedicine still unavailable literature. This review summarizes microenvironmental characteristics DFU, presents main progress wound healing, summaries state-of-the-art strategies DFU. Furthermore, challenges future perspectives this field discussed prospected, aiming fuel foster development nanomedicines successfully.

Language: Английский

Citations

200
All-in-one bioactive properties of photothermal nanofibers for accelerating diabetic wound healing DOI Creative Commons
Yanan Zhao, Chuan Tian, Yiming Liu

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 295, P. 122029 - 122029

Published: Jan. 28, 2023

Diabetic wound healing has attracted widespread attention in biomedical engineering. However, the harsh hypoxic microenvironment (HME) comprising high glucose levels, local bleeding, and bacterial infection often leads to formation of hyperplastic scars, increasing clinical demand for dressings. Here, we report a comprehensive strategy using near-infrared NIR-assisted oxygen delivery combined with bioactive nature biopolymers remodeling HME. Black phosphorus (BP) nanosheets hemoglobin (Hb) were self-assembled layerwise onto electrospun poly-l-lactide (PLLA) nanofibers charged quaternized chitosan (QCS) hyaluronic acid. BP converts NIR radiation into heat stimulates Hb release situ. QCS is hemostatic broad-spectrum antibacterial material. Moderate BP-derived photothermal therapy can increase sensitivity bacteria QCS. A series composite dressings (coded as PQBH-n) different numbers layers fabricated, vivo diabetic potentials tested. The molecular mechanism be partly attributed cytokine-cytokine receptor interaction. Notably, this based on properties not only applicable fabricating multifunctional but also great potential expanding engineering fields.

Language: Английский

Citations

83
Amorphizing Metal Selenides-Based ROS Biocatalysts at Surface Nanolayer toward Ultrafast Inflammatory Diabetic Wound Healing DOI
Yuting Deng, Yang Gao, Tiantian Li

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(3), P. 2943 - 2957

Published: Jan. 23, 2023

The microenvironments with high reactive-oxygen-species (ROS) levels, inflammatory responses, and oxidative-stress effects in diabetic ulcer wounds, leading to poor proliferation differentiation of stem cells, severely inhibit their efficient healing. Here, overcome the unbalanced multielectron reactions ROS catalysis, we develop a cobalt selenide-based biocatalyst an amorphous Ru@CoSe nanolayer for ultrafast broad-spectrum catalytic ROS-elimination. Owing enriched electrons more unoccupied orbitals Ru atoms, nanolayer-equipped displays excellent catalase-like kinetics (maximal reaction velocity, 23.05 μM s–1; turnover number, 2.00 s–1), which exceeds most currently reported metal compounds. theoretical studies show that atoms act as "regulators" tune electronic state Co sites modulate interaction oxygen intermediates, thus improving reversible redox properties active sites. Consequently, can efficiently rescue mesenchymal cells maintain angiogenic potential oxidative stress environment. In vivo experiments reveal superior ROS-elimination ability on wound. This study offers effective nanomedicine ROS-scavenging healing wounds also provides strategy design biocatalytic compounds via bringing structures.

Language: Английский

Citations

78
Stimuli-responsive polysaccharide-based smart hydrogels for diabetic wound healing: Design aspects, preparation methods and regulatory perspectives DOI

Tejaswini Kolipaka,

Giriraj Pandey,

Noella Abraham

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 324, P. 121537 - 121537

Published: Nov. 2, 2023

Language: Английский

Citations

57
Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy DOI Creative Commons
Xi Lu,

Qingxing Xie,

Xiaohui Pan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 2, 2024

Language: Английский

Citations

54
Framework Nucleic Acids‐Based VEGF Signaling Activating System for Angiogenesis: A Dual Stimulation Strategy DOI Creative Commons
Yichen Ge, Qingxuan Wang,

Yangxue Yao

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(21)

Published: March 9, 2024

Abstract Angiogenesis is crucial for tissue engineering, wound healing, and regenerative medicine. Nanomaterials constructed based on specific goals can be employed to activate endogenous growth factor‐related signaling. In this study, the conventional single‐stranded DNA self‐assembly into tetrahedral framework nucleic acids (tFNAs), Apt02 acid aptamer dimethyloxallyl glycine (DMOG) small molecule are integrated a complex via template‐based click chemistry reaction toehold‐mediated strand displacement reaction. Thus, being able simulate VEGF (vascular endothelial factor) function stabilize HIF (hypoxia‐inducible factor), functional whole applied angiogenesis. Cellular studies demonstrate that tFNAs‐Apt02 (TAC) has conspicuous affinity human umbilical vein cells (HUVECs). Further incubation with DMOG yields tFNAs‐Apt02‐DMOG (TACD), which promotes secretion, in vitro blood vessel formation, sprouting, migration of HUVECs. Additionally, TACD enhances angiogenesis by upregulating VEGF/VEGFR signaling pathways. Moreover, diabetic mouse skin defect repair process, increases formation collagen deposition, therefore accelerating healing. The novel strategy simulating stabilizing blood‐vessel vivo potential broad applications vascularization field.

Language: Английский

Citations

38
Antibacterial microneedle patch releases oxygen to enhance diabetic wound healing DOI Creative Commons
Mengli Sun, Xiqiang Zhong,

Minghai Dai

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 24, P. 100945 - 100945

Published: Jan. 4, 2024

Cell growth and metabolism require an adequate supply of oxygen. However, obtaining sufficient oxygen from the blood circulating around diabetic wounds is challenging. Nevertheless, achieving a continuous stable required for these to heal. Hence, in this study, we report novel antibacterial oxygen-producing silk fibroin methacryloyl hydrogel microneedle (MN) patch comprising tips encapsulated with calcium peroxide catalase base coated Ag nanoparticles (AgNPs). The tip MN continuously releases inhibits production reactive species. This accelerates wound healing by promoting cellular accretion migration, macrophage M2 polarization, angiogenesis. AgNPs at effectively combat microbial infection, further facilitating repair. These findings suggest that using multifunctional may be promising strategy clinical settings.

Language: Английский

Citations

23