Phytomedicine, Journal Year: 2024, Volume and Issue: 131, P. 155805 - 155805
Published: June 4, 2024
Language: Английский
The Lancet, Journal Year: 2023, Volume and Issue: 401(10384), P. 1302 - 1312
Published: March 14, 2023
Language: Английский
Citations
132
Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11
Published: Oct. 13, 2023
Aging is a progressive and irreversible pathophysiological process that manifests as the decline in tissue cellular functions, along with significant increase risk of various aging-related diseases, including metabolic diseases. While advances modern medicine have significantly promoted human health extended lifespan, diseases such obesity type 2 diabetes among older adults pose major challenge to global public societies age. Therefore, understanding complex interaction between factors crucial for promoting well-being healthy aging. This review article explores environmental behavioral associated their impact on The environment, an obesogenic environment exposure toxins, strongly correlated rising prevalence its comorbidities. Behavioral factors, diet, physical activity, smoking, alcohol consumption, sleep patterns, influence throughout Public interventions targeting modifiable can effectively promote healthier lifestyles prevent Collaboration government agencies, healthcare providers community organizations essential implementing these creating supportive environments foster
Language: Английский
Citations
56
Antioxidants, Journal Year: 2023, Volume and Issue: 12(1), P. 123 - 123
Published: Jan. 4, 2023
The global prevalence of diabetes continues to increase partly due rapid urbanization and an in the aging population. Consequently, this is associated with a parallel diabetic vascular complications which significantly worsen burden diabetes. For these complications, there still unmet need for safe effective alternative/adjuvant therapeutic interventions. There also increasing urge options come from natural products such as plants. Hyperglycemia-induced oxidative stress central development complications. Furthermore, stress-induced inflammation insulin resistance are endothelial damage progression Human animal studies have shown that polyphenols could reduce stress, hyperglycemia, prevent including retinopathy, nephropathy, peripheral neuropathy. Part effects attributed their modulatory effect on endogenous antioxidant systems. This review attempts summarize established systems literature. Moreover, potential strategies harnessing benefits discussed.
Language: Английский
Citations
50
Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13
Published: Jan. 23, 2025
Objective To produce estimates of the global burden type 2 diabetes mellitus (T2DM) caused by high body mass index (high BMI) and its impact for 2021 projections 2045. Methods We downloaded data from Global Burden Disease Study 2021(GBD 2021) to estimate disease T2DM BMI. Secondary analyses were performed year, age, gender, region, socio-demographic (SDI). Results Globally, all-ages number T2DM-related deaths has increased significantly 238.1 thousand 723.7 thousand, representing a 203.9% increase since 1990. And T2DM-raleted DALYs raised 10.4 million 39.3 million, 276.7% The was expected continue 1296.7 2045 deaths, 85.5 DALYs. curves showed an intersection different genders around age 60, beyond which women exhibit higher burden, compared men. BMI shows significant upward trend across all SDI groups, with heavier on women, especially in postmenopausal female population. In 2021, among 204 countries territories, top 3 largest occurred China, India, United States. three highest rate Fiji, Marshall Islands, Kiribati. Conclusion Our study reveals that is increasing rising future. Women bear particularly there are differences geographical regions, socioeconomic statuses. Targeted considerations specific strategies essential address these disparities, thereby improving public health reducing burden.
Language: Английский
Citations
3
Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 19(3), P. 151 - 163
Published: Nov. 29, 2022
Language: Английский
Citations
50
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: June 29, 2022
Atherosclerosis is one of the main complications diabetes mellitus, involving a variety pathogenic factors. Endothelial dysfunction, inflammation, and oxidative stress are hallmarks mellitus atherosclerosis. Although ability to promote atherosclerosis has been demonstrated, deeper understanding underlying biological mechanisms critical identifying new targets. NLRP3 plays an important role in both While diversity its activation modes causes complex effects progression atherosclerosis, it also provides many insights for targeted interventions metabolic diseases.
Language: Английский
Citations
47
Soft Science, Journal Year: 2022, Volume and Issue: 2(2), P. 9 - 9
Published: Jan. 1, 2022
Wound healing is one of the most complex processes in human body, supported by many cellular events that are tightly coordinated to repair wound efficiently. Chronic wounds have potentially life-threatening consequences. Traditional dressings come direct contact with help them heal and avoid further complications. However, traditional some limitations. These do not provide real-time information on conditions, leading clinicians miss best time for adjusting treatment. Moreover, current diagnosis relatively subjective. Wearable electronics become a unique platform monitor conditions continuous manner accurately even serve as accelerated vehicles. In this review, we briefly discuss status objective parameters/biomarkers influencing healing, followed presentation various novel wearable devices used monitoring accelerating healing. We summarize associated device working principles. This review concludes highlighting major challenges toward need be addressed research community.
Language: Английский
Citations
47
Hepatology, Journal Year: 2022, Volume and Issue: 76(5), P. 1409 - 1422
Published: March 25, 2022
Abstract Background and Aims Several guidelines recommend screening for NAFLD in patients with type 2 diabetes (T2D). We aimed to determine if there is a threshold of age duration T2D liver‐related event development guide strategies. Approach Results conducted territory‐wide retrospective cohort study adult diagnosed between 2000 2014 Hong Kong allow at least 5 years follow‐up. The primary endpoint was events, defined as composite HCC cirrhotic complications. This included 7028 (mean age, 56.1 ± 13.3 years; 3363 male [47.9%]). During follow‐up 77,308 person‐years, effect 1.1%, 4.9%, 94.0% developing events the <40, 40–50, ≥50 years, respectively. Similarly, 3.1%, 5.1%, 91.8% developed cirrhosis In contrast, increased linearly duration, no difference annual incidence rate first 10 diagnosis subsequent (0.06% vs. 0.10%; p = 0.136). On multivariable analysis, baseline (adjusted HR [aHR] 2.01) (aHR 3.12) were strongest risk factors associated events. Substitution aspartate aminotransferase‐to‐platelet ratio index or Fibrosis‐4 yielded similar results. Conclusions Age rather than predicts T2D. It reasonable screen advanced liver disease starting 50 age.
Language: Английский
Citations
41
Cells, Journal Year: 2023, Volume and Issue: 12(4), P. 583 - 583
Published: Feb. 11, 2023
Previous studies demonstrated an important role of oxidative stress in the pathogenesis cardiovascular disease (CVD) diabetic patients due to hyperglycemia. CVD remains leading cause premature death western world. Therefore, diabetes mellitus-associated and subsequent inflammation should be recognized at earliest possible stage start with appropriate treatment before onset sequelae such as arterial hypertension or coronary artery (CAD). The pathophysiology comprises increased reactive oxygen nitrogen species (RONS) production by enzymatic non-enzymatic sources, e.g., mitochondria, uncoupled nitric oxide synthase, xanthine oxidase, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX). Considering that RONS originate from different cellular mechanisms separate compartments, adequate, sensitive, compartment-specific methods for their quantification are crucial early detection. In this review, we provide overview these information early, appropriate, effective sequelae.
Language: Английский
Citations
31
Nano Energy, Journal Year: 2023, Volume and Issue: 118, P. 108989 - 108989
Published: Oct. 13, 2023
Language: Английский
Citations
31