Effect of Time-Restricted Eating on Weight Loss in Adults With Type 2 Diabetes

JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(10), P. e2339337 - e2339337

Published: Oct. 27, 2023

Importance Time-restricted eating (TRE) has become increasingly popular, yet longer-term randomized clinical trials have not evaluated its efficacy and safety in patients with type 2 diabetes (T2D). Objective To determine whether TRE is more effective for weight reduction glycemic control than daily calorie restriction (CR) or a condition adults T2D. Design, Setting, Participants This 6-month, parallel-group, trial was performed between January 25, 2022, April 1, 2023, at the University of Illinois Chicago. were aged 18 to 80 years obesity Data analysis based on intention treat. Interventions 1 3 groups: 8-hour (eating 12 8 pm only, without counting), CR (25% energy daily), control. Main Outcomes Measures The primary outcome measure change body by month 6. Secondary outcomes included changes hemoglobin A 1c (HbA ) levels metabolic risk factors. Results Seventy-five participants enrolled mean (SD) age 55 (12) years. mass index (calculated as kilograms divided height meters squared) 39 (7) HbA level 8.1% (1.6%). total 53 (71%) women. One participant (1%) Asian, 30 (40%) Hispanic White, 40 (53%) non-Hispanic Black, 4 (5%) White. group adherent their window 6.1 (0.8) days per week, 17 (68%) prescribed goals over 6 months. intake −313 (509) kcal/d TRE, −197 (426) CR, −16 (439) controls. By 6, decreased significantly (−3.56% [95% CI, −5.92% −1.20%]; P = .004) but (−1.78% −3.67% 0.11%]; .06), relative Levels (−0.91% −1.61% −0.20%]) (−0.94% −1.59% −0.30%]) groups, controls, no differences groups. Time euglycemic range, medication effect score, blood pressure, plasma lipid did differ among No serious adverse events reported. Conclusions relevance found that diet strategy counting loss lowering compared sample These findings will need be confirmed larger RCTs longer follow-up. Trial Registration ClinicalTrials.gov Identifier: NCT05225337

Language: Английский

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Time-restricted eating: Watching the clock to treat obesity

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 301 - 314

Published: Jan. 3, 2024

Language: Английский

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Interorgan rhythmicity as a feature of healthful metabolism

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(4), P. 655 - 669

Published: Feb. 8, 2024

Language: Английский

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Nanoplastics Toxicity Specific to Liver in Inducing Metabolic Dysfunction—A Comprehensive Review

Genes, Journal Year: 2023, Volume and Issue: 14(3), P. 590 - 590

Published: Feb. 26, 2023

Plastic pollution in the world is widespread and growing. The environment swamped with nanoplastics (<100 nm), health consequences of these less visible pollutants are unknown. Furthermore, there evidence that microplastics can release by digestive disintegration, implying macroplastic exposure cause direct indirect disease via nanoplastics. existence impact numerous tissues from invertebrates to larger vertebrates consume significant amounts plastics were investigated, histopathological techniques utilized determine physiological reactions inflammation plastics. Nanoplastics enters an organism through respiratory gastro-intestinal tract where they accumulate into liver blood circulation absorption, or epidermal infiltration. It stated macroplastics damage directly at site exposure, whereas influence liver, causing subsequent other organs. Multi-organ dysfunction brought on changes, readily enter gut-liver axis disturb gut microflora. By exploring literature summarizing research has been published date, this review article reveals deleterious effect mechanisms pathophysiological functions hepatic system.

Language: Английский

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Circadian desynchrony and glucose metabolism

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(4)

Published: May 1, 2024

Abstract The circadian timing system controls glucose metabolism in a time‐of‐day dependent manner. In mammals, the consists of main central clock bilateral suprachiasmatic nucleus (SCN) anterior hypothalamus and subordinate clocks peripheral tissues. oscillations produced by these different with period approximately 24‐h are generated transcriptional‐translational feedback loops set core genes. Glucose homeostasis is one daily rhythms controlled this system. pacemaker SCN through its neural projections to hypothalamic hubs that control feeding behavior energy metabolism. Using hormones such as adrenal glucocorticoids melatonin autonomic nervous system, modulates critical processes production insulin sensitivity. Peripheral tissues, liver, muscle, adipose tissue serve enhance sustain signals. optimal situation all synchronized aligned environmental light/dark cycle. A negative impact on becomes apparent when internal disturbed, also known desynchrony or misalignment. Circadian may occur at several levels, mistiming light exposure sleep will especially affect clock, whereas food intake physical activity involve clocks. review, we summarize literature investigating how it result development resistance. addition, discuss potential strategies aimed reinstating synchrony improve sensitivity contribute prevention type 2 diabetes.

Language: Английский

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2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association

Diabetes & Metabolism Journal, Journal Year: 2024, Volume and Issue: 48(4), P. 546 - 708

Published: July 29, 2024

Language: Английский

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Protocol for a 1‐year randomised, controlled, parallel group, open‐label trial on the effects and feasibility of time‐restricted eating in individuals with type 2 diabetes‐ The Restricted Eating Time in the Treatment of Type 2 Diabetes (RESET2) trial

Diabetic Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Abstract Aim Time‐restricted eating (TRE) limits the time for food intake to typically 6–10 h/day without other dietary restrictions. The aim of RESET2 (the REStricted Eating Time in treatment type 2 diabetes) trial is investigate effects on glycaemic control (HbA 1c ) and feasibility a 1‐year TRE intervention individuals with overweight/obesity diabetes. present paper describe protocol trial. Methods randomised, controlled, parallel‐group, open‐label One hundred sixty diabetes >53 mmol/mol (>7.0%)), Body Mass Index ≥25 kg/m will be randomised standard care plus TRE, or habitual living. Both group follow including regular clinical visits 3–4 times/year. divided into two periods: (1) 3‐month period fixed window self‐selected timing obtain data from participants' experiences (2) 9‐month individually adjusted period. Participants instructed reduce their by minimum 3 compared an 8–10 h/day. Test days scheduled at baseline, after months 1 year. primary outcome HbA (evaluated year randomisation) secondary outcomes are body weight, fat mass, continuous glucose monitoring derived time‐in‐range use antidiabetic medicine randomisation). Additionally, we conduct process evaluation assess whether functioned as hypothesised.

Language: Английский

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Physiological rhythms and metabolic regulation: Shining light on skeletal muscle

Experimental Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Metabolic regulation is essential for maintaining homeostasis in response to fluctuating dietary nutrient availability. In this review, we explore how metabolic health can be affected by the temporal alignment between daily behavioural patterns (e.g., eating, physical activity and sleep) recurring cycles underlying physiology ‘circadian’ rhythms). Misalignment within and/or these lead dysregulation, increasing risk of chronic disease states such as obesity, type 2 diabetes cardiovascular disease. Conversely, improved strategically aligning certain with endogenous rhythms physiology. Dietary interventions based upon reasoning are referred chrono‐nutrition strategies. Skeletal muscle an important tissue relation both whole‐body metabolism behaviour plays a central role physiological respond timing delivery/availability. Few studies have examined human skeletal muscle, providing opportunities advance current understanding affects metabolism.

Language: Английский

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Effects of Time-Restricted Feeding and Ramadan Fasting on Body Weight, Body Composition, Glucose Responses, and Insulin Resistance: A Systematic Review of Randomized Controlled Trials

Nutrients, Journal Year: 2022, Volume and Issue: 14(22), P. 4778 - 4778

Published: Nov. 11, 2022

Time-restricted feeding (TRF) and Ramadan fasting (RF) have been recently associated with several health outcomes. However, it is not yet clear if they are superior to existing treatments in terms of glucose metabolism, insulin action, weight loss. This review aims summarize the current data on effects these regimes body weight, composition, glycemia. An electronic search was conducted PUBMED SCOPUS databases up August 2022. Twenty-four records met inclusion criteria underwent a risk-of-bias assessment. The main outcomes were: (a) TRF may result moderate loss individuals overweight/obesity; when combined caloric restriction, >5% initial (b) 14 h be as effective 16 loss, (c) lead improved sensitivity glycemic responses/variability throughout day overweight/obesity. Concerning RF, only two studies were available thus, conclusions drawn. an nutritional approach for amelioration control more long-term, well-designed needed.

Language: Английский

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Feasibility of time‐restricted eating in individuals with overweight, obesity, prediabetes, or type 2 diabetes: A systematic scoping review

Obesity, Journal Year: 2023, Volume and Issue: 31(6), P. 1463 - 1485

Published: May 19, 2023

Abstract Objective This systematic scoping review aimed to map and synthesize research on feasibility of time‐restricted eating (TRE) in individuals with overweight, obesity, prediabetes, or type 2 diabetes, including recruitment rate, retention safety, adherence, participants' attitudes, experiences, perspectives. Methods The authors searched MEDLINE, Embase, Cumulative Index Nursing Allied Health Literature from inception November 22, 2022, supplemented by backward forward citation search. Results From 4219 identified records, 28 studies were included. In general, was easy median rate 95% among <12 weeks duration 89% ≥12 weeks. Median (range) adherence the target window for (75%–98%) 81% (47%–93%), respectively. Variation participants considerable, indicating that following TRE difficult some people intervention conditions influenced adherence. These findings supported qualitative data synthetized seven studies, determinants included calorie‐free beverages outside window, provision support, influence window. No serious adverse events reported. Conclusions is implementable, acceptable, safe populations but it should be accompanied support options individual adjustments.

Language: Английский

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