Nanoparticles in cancer theragnostic and drug delivery: A comprehensive review

Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122899 - 122899

Published: July 9, 2024

This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.

Language: Английский

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Nanocellulose-based hydrogels as versatile materials with interesting functional properties for tissue engineering applications

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(32), P. 7692 - 7759

Published: Jan. 1, 2024

Tissue engineering has emerged as a remarkable field aiming to repair or replace damaged tissues through the use of biomimetic constructs.

Language: Английский

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Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3849 - 3849

Published: March 29, 2024

This state-of-the-art review explores the emerging field of regenerative hydrogels and their profound impact on treatment skin wounds. Regenerative hydrogels, composed mainly water-absorbing polymers, have garnered attention in wound healing, particularly for Their unique properties make them well suited tissue regeneration. Notable benefits include excellent water retention, creating a crucially moist environment optimal facilitating cell migration, proliferation. Biocompatibility is key feature, minimizing adverse reactions promoting natural healing process. Acting as supportive scaffold growth, mimic extracellular matrix, aiding attachment proliferation cells like fibroblasts keratinocytes. Engineered controlled drug release, enhance by angiogenesis, reducing inflammation, preventing infection. The demonstrated acceleration process, beneficial chronic or impaired wounds, adds to appeal. Easy application conformity various shapes practical, including irregular challenging areas. Scar minimization through regeneration crucial, especially cosmetic functional regions. Hydrogels contribute pain management protective barrier, friction, fostering soothing environment. Some with inherent antimicrobial properties, aid infection prevention, which crucial aspect successful healing. flexibility ability conform contours ensure contact, enhancing overall effectiveness. In summary, present promising approach improving outcomes across diverse clinical scenarios. provides comprehensive analysis benefits, mechanisms, challenges associated use this review, authors likely delve into rational design principles efficacy performance Through an exploration methodologies approaches, paper poised highlight how these been instrumental refining potentially revolutionizing therapeutic potential addressing By synthesizing current knowledge highlighting avenues future research, aims advancement medicine ultimately improve patients

Language: Английский

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Extraction and characterization of novel fibers from Tecoma stans Linn bark for use as reinforcement in polymer composites

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132492 - 132492

Published: May 17, 2024

Language: Английский

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Biomaterials-based hydrogels for therapeutic applications

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 23, 2024

Conventional therapeutic models based on the premise of a universal solution are facing decrease in efficiency, emphasized by large number patients who show resistance or do not respond positively to classic treatments. This perspective highlights urgency for more precise approaches personalized treatments that adaptable specific complexities and unique challenges faced each patient. Hydrogels biocompatible biodegradable systems well-controlled targeted administration agents, being formed 3D reticulated networks water-soluble polymeric biomaterials, natural, synthetic, hybrid origin, with intrinsic extrinsic properties. Due easily adjustable porous structure, hydrogels allow encapsulation macromolecular drugs, proteins, small molecules, cells, hormones, growth factors gel matrix their subsequent controlled release. The biomaterials used, crosslinking methods, design, functionalization strategies obtaining improved properties presented. different possibilities application described transdermally, as dressing materials, oral, ocular, spray-able, injectable, up intracellular level. chapter extensively investigates advances advantages enable effective, noninvasive, provide greater patient comfort wide range applications.

Language: Английский

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Engineering bone/cartilage organoids: strategy, progress, and application

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Nov. 20, 2024

Abstract The concept and development of bone/cartilage organoids are rapidly gaining momentum, providing opportunities for both fundamental translational research in bone biology. Bone/cartilage organoids, essentially miniature tissues grown vitro, enable the study complex cellular interactions, biological processes, disease pathology a representative controlled environment. This review provides comprehensive up-to-date overview field, focusing on strategies organoid construction strategies, progresses research, potential applications. We delve into significance selecting appropriate cells, matrix gels, cytokines/inducers, techniques. Moreover, we explore role advancing our understanding reconstruction, modeling, drug screening, prevention, treatment strategies. While acknowledging these discuss inherent challenges limitations field propose solutions, including use bioprinting induction, AI improved screening exploration assembloids more complex, multicellular models. believe that with continuous refinement standardization, can profoundly impact patient-specific therapeutic interventions lead way regenerative medicine.

Language: Английский

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Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations

Gels, Journal Year: 2024, Volume and Issue: 10(5), P. 295 - 295

Published: April 25, 2024

Biomedicine is constantly evolving to ensure a significant and positive impact on healthcare, which has resulted in innovative distinct requisites such as hydrogels. Chitosan-based formulations stand out for their versatile utilization drug encapsulation, transport, controlled release, complemented by biocompatibility, biodegradability, non-immunogenic nature. Stimuli-responsive hydrogels, also known smart have strictly regulated release patterns since they respond adapt based various external stimuli. Moreover, can imitate the intrinsic tissues’ mechanical, biological, physicochemical properties. These characteristics allow stimuli-responsive hydrogels provide cutting-edge, effective, safe treatment. Constant progress field necessitates an up-to-date summary of current trends breakthroughs biomedical application chitosan-based was aim this review. General data about sensitive ions, pH, redox potential, light, electric field, temperature, magnetic are recapitulated. Additionally, responsive multiple stimuli mentioned. Focusing multifaceted thoroughly described. The vast spectrum encompasses neurological disorders, tumors, wound healing, dermal infections. Available chitosan strongly support idea that approaches developing novel solutions worth improving. present paper constitutes valuable resource researchers practitioners currently field.

Language: Английский

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Harnessing the potential of nanostructured materials for sustainable development

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 38, P. 101216 - 101216

Published: May 1, 2024

Language: Английский

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Adaptive and intelligent polyurethane shape-memory polymers enabling next-generation biomedical platforms

Case Studies in Chemical and Environmental Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 101165 - 101165

Published: Feb. 1, 2025

Language: Английский

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Comprehensive review of metal complexes and nanocomposites: Synthesis, characterization, and multifaceted biological applications

Engineering Science & Technology Journal, Journal Year: 2024, Volume and Issue: 5(6), P. 1935 - 1951

Published: June 13, 2024

This review paper provides an extensive analysis of the synthesis, characterization, and multifaceted biological applications metal complexes nanocomposites derived from a diverse array biopolymeric ligands. These ligands, including chitosan, 2-hydroxybenzaldehyde, 4-aminopyridine imine, among others, have shown remarkable potential due to their biocompatibility, biodegradability, functional versatility. The delves into various synthetic strategies, conventional green synthesis approaches, highlights advanced characterization techniques such as spectroscopy, microscopy, thermal analysis, X-ray diffraction. Emphasizing broad spectrum activities exhibited by these compounds, covers antimicrobial, anticancer, antioxidant, enzyme inhibition, drug delivery applications. By synthesizing current research identifying key challenges future directions, this aims provide valuable insights for researchers in medicinal chemistry, materials science, biotechnology, related fields. Keywords: Metal Complexes, Nanocomposites, Synthesis, Characterization, Biological Application.

Language: Английский

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