Annals of the New York Academy of Sciences,
Journal Year:
2018,
Volume and Issue:
1451(1), P. 71 - 91
Published: Oct. 5, 2018
Impulsivity
is
strongly
associated
with
substance
use
disorders
(SUDs).
Our
review
discusses
impulsivity
as
an
underlying
vulnerability
marker
for
SUDs,
and
treatment
of
co-occurring
in
SUDs.
Three
factors
should
be
considered
the
complex
relationship
between
a
SUD:
(1)
trait
effect
impulsivity,
centering
on
decreased
cognitive
response
inhibition,
(2)
state
resulting
from
either
acute
or
chronic
brain
structure
function,
(3)
genetic
environmental
(e.g.,
age
sex)
may
influence
impulsive
behavior
Both
subjective
objective
measures
are
used
to
assess
impulsivity.
Together,
developments
(pharmacological,
behavioral,
neurophysiological)
consider
these
clinically
relevant
dimensions
assessed
by
variety
measures,
which
have
implications
matching
individuals
SUD.
Despite
its
heterogeneity,
SUDs
understood
imbalance
bottom-up
top-down
neural
systems.
Further
investigation
relationships
lead
more
effective
SUD
treatments.
Addiction,
Journal Year:
2009,
Volume and Issue:
104(12), P. 1966 - 1978
Published: Nov. 9, 2009
ABSTRACT
Aims
Anabolic–androgenic
steroids
(AAS)
are
widely
used
illicitly
to
gain
muscle
and
lose
body
fat.
Here
we
review
the
accumulating
human
animal
evidence
showing
that
AAS
may
cause
a
distinct
dependence
syndrome,
often
associated
with
adverse
psychiatric
medical
effects.
Method
We
present
an
illustrative
case
of
dependence,
followed
by
summary
literature
on
this
topic,
based
publications
known
us
or
obtained
searching
PubMed
database.
Results
About
30%
users
appear
develop
characterized
chronic
use
despite
effects
physical,
psychosocial
occupational
functioning.
shares
many
features
classical
drug
dependence.
For
example,
hamsters
will
self‐administer
AAS,
even
point
death,
both
humans
animals
exhibit
well‐documented
withdrawal
mediated
neuroendocrine
cortical
neurotransmitter
systems.
particularly
involve
opioidergic
mechanisms.
However,
differ
from
drugs
in
they
produce
little
immediate
reward
acute
intoxication,
but
instead
delayed
effect
gains.
Thus
standard
diagnostic
criteria
for
substance
usually
crafted
acutely
intoxicating
drugs,
must
be
adapted
slightly
cumulatively
acting
such
as
AAS.
Conclusions
is
valid
entity,
probably
growing
public
health
problem.
share
brain
mechanisms
other
forms
especially
opioid
Future
studies
needed
characterize
more
clearly,
identify
risk
factors
syndrome
treatment
strategies.
Annals of the New York Academy of Sciences,
Journal Year:
2014,
Volume and Issue:
1327(1), P. 1 - 26
Published: March 21, 2014
Addictions
are
often
characterized
as
forms
of
impulsive
behavior.
That
said,
it
is
noted
that
impulsivity
a
multidimensional
construct,
spanning
several
psychological
domains.
This
review
describes
the
relationship
between
varieties
and
addiction‐related
behaviors,
nature
causal
two,
underlying
neurobiological
mechanisms
promote
behaviors.
We
conclude
available
data
strongly
support
notion
both
risk
factor
for,
consequence
of,
drug
alcohol
consumption.
While
evidence
indicating
subtypes
behavior
uniquely
informative—either
biologically
or
with
respect
to
their
relationships
addictions—is
convincing,
multiple
lines
study
link
distinct
low
dopamine
D2
receptor
function
perturbed
serotonergic
transmission,
revealing
shared
subtypes.
Therefore,
common
biological
framework
involving
monoaminergic
transmitters
in
key
frontostriatal
circuits
may
self‐administration
Further
dissection
these
needed
before
next
phase
genetic
genomic
discovery
will
be
able
reveal
sources
vulnerability
for
addiction
indexed
by
impulsivity.
