Double-blind randomized N-of-1 trial of transcranial alternating current stimulation for mal de débarquement syndrome DOI Creative Commons
Yoon‐Hee Cha,

Diamond Gleghorn,

Benjamin Doudican

et al.

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(2), P. e0263558 - e0263558

Published: Feb. 4, 2022

Background Mal de Débarquement Syndrome (MdDS) is a medically refractory neurotological disorder characterized by persistent oscillating vertigo that follows period of entrainment to motion such as experienced during sea or air travel. Fronto-occipital hypersynchrony may correlate with MdDS symptom severity. Materials and methods Individuals treatment lasting at least 6 months received single administrations three fronto-occipital transcranial alternating current stimulation (tACS) protocols in an “n-of-1” double-blind randomized design: alpha frequency anti-phase, alpha-frequency in-phase, gamma control. Baseline assessments were made on Day 1. The protocol led the most acute reduction symptoms test session 2 was administered for 10–12 stacked sessions given Days 3 through 5 (20-minutes 2-4mA). Pre post changes assessed 1 5. Participants who could clearly choose preferred did better than those not make short-term determination either chose based minimized side effects one protocols. In addition, weekly four baseline seven points Dizziness Handicap Inventory (DHI), Balance Rating Scale (MBRS), Hospital Anxiety Depression (HADS). Results Of 24 participants, 13 7 4 control stimulation. Compared baseline, 10/24 completers noted ≥ 25% reduction, 5/24 ≥50% 2/24 ≥75% intensity from Stimulating slightly higher individual (IAF) stimulating exactly IAF, strategy standardized 10Hz. A one-way repeated measures ANOVA DHI, MBRS, HADS measurements showed significant reductions immediately after improvement increasing post-treatment week 6. Conclusion tACS be effective reducing serve portable neuromodulation alternative longer-term treatment. Stimulation relative IAF important determining optimum [ClinicalTrials.gov study NCT02540616. https://clinicaltrials.gov/ct2/show/NCT02540616 ].

Language: Английский

Transcranial alternating current stimulation (tACS): from basic mechanisms towards first applications in psychiatry DOI Creative Commons
Osama Elyamany, Gregor Leicht, Christoph S. Herrmann

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2020, Volume and Issue: 271(1), P. 135 - 156

Published: Nov. 19, 2020

Abstract Transcranial alternating current stimulation (tACS) is a unique form of non-invasive brain stimulation. Sinusoidal electric currents are delivered to the scalp affect mostly cortical neurons. tACS supposed modulate function and, in turn, cognitive processes by entraining oscillations and inducing long-term synaptic plasticity. Therefore, has been investigated neuroscience, but only recently, it also introduced psychiatric clinical trials. This review describes concepts first findings applying as potential therapeutic tool field psychiatry. The understanding its mechanisms action explained, bridging cellular neuronal activity network mechanism. Revisiting relevance altered found six major disorders, putative targets for management mental disorders using discussed. A systematic literature search on PubMed was conducted report studies patients with conditions. In conclusion, initial results may support feasibility populations without serious adverse events. Moreover, these showed ability reset disturbed oscillations, thus improve behavioural outcomes. addition role, reactivity circuits could serve possible determine diagnosis, classification or prognosis disorders. Future double-blind randomised controlled trials necessary answer currently unresolved questions. They aim detect response predictors control various confounding factors.

Language: Английский

Citations

204
State-dependent effects of neural stimulation on brain function and cognition DOI
Claire Bradley, Abbey S. Nydam, Paul E. Dux

et al.

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(8), P. 459 - 475

Published: May 16, 2022

Language: Английский

Citations

129
The Modulation of Cognitive Performance with Transcranial Alternating Current Stimulation: A Systematic Review of Frequency-Specific Effects DOI Creative Commons
Katharina Klink, Sven Paßmann, Florian H. Kasten

et al.

Brain Sciences, Journal Year: 2020, Volume and Issue: 10(12), P. 932 - 932

Published: Dec. 2, 2020

Transcranial alternating current stimulation (tACS) is a non-invasive brain technique that allows the manipulation of intrinsic oscillations. Numerous studies have applied tACS in laboratory to enhance cognitive performance. With this systematic review, we aim provide an overview frequency-specific effects on range functions healthy adults. This may help transfer protocols real-world applications. We conducted literature search PubMed and Cochrane databases considered adults (age > 18 years) focused The yielded n = 109 studies, which 57 met inclusion criteria. results indicate theta-tACS was beneficial for several functions, including working memory, executive declarative memory. Gamma-tACS enhanced performance both auditory visual perception but it did not change tasks functions. For attention, were less consistent point improvement with alpha- or gamma-tACS. discuss these findings important considerations would precede

Language: Английский

Citations

81
The impact of gamma transcranial alternating current stimulation (tACS) on cognitive and memory processes in patients with mild cognitive impairment or Alzheimer's disease: A literature review DOI Creative Commons
Nicole R. Nissim,

Duc Viet Pham,

T Poddar

et al.

Brain stimulation, Journal Year: 2023, Volume and Issue: 16(3), P. 748 - 755

Published: April 5, 2023

Highlights•40 Hz tACS enhances gamma oscillations and memory performance in MCI/AD patients.•Active 40 increases spectral power patients over sham.•Gamma stimulation may aid clearance of tau mouse models AD patients.AbstractBackgroundTranscranial alternating current (tACS)—a noninvasive brain technique that modulates cortical through entrainment—has been demonstrated to alter oscillatory activity enhance cognition healthy adults. TACS is being explored as a tool improve patient populations with mild cognitive impairment (MCI) Alzheimer's disease (AD).ObjectiveTo review the growing body literature findings obtained from application MCI or AD, highlighting effects on function, memory, cognition. Evidence use animal also discussed. Important parameters are underscored for consideration protocols aim apply therapeutic MCI/AD.FindingsThe has shown promising results improvement processes impacted MCI/AD. These data demonstrate potential an interventional stand-alone alongside pharmacological and/or other behavioral interventions MCI/AD.ConclusionsWhile evidenced encouraging results, this function pathophysiology remains be fully determined. This explores highlights need continued research course by reinstating activity, improving processing, delaying progression, remediating abilities

Language: Английский

Citations

42
A meta-analysis showing improved cognitive performance in healthy young adults with transcranial alternating current stimulation DOI Creative Commons
Tae Lee Lee,

Hanall Lee,

Nyeonju Kang

et al.

npj Science of Learning, Journal Year: 2023, Volume and Issue: 8(1)

Published: Jan. 3, 2023

Abstract Transcranial alternating current stimulation (tACS) is a non-invasive brain used for improving cognitive functions via delivering weak electrical with certain frequency. This systematic review and meta-analysis investigated the effects of tACS protocols on in healthy young adults. We identified 56 qualified studies that compared between sham control groups, as indicated by performances cognition-related reaction time. Moderator variable analyses specified effect size according to (a) timing tACS, (b) frequency band simulation, (c) targeted region, domain, respectively. Random-effects model revealed small positive performances. The moderator found significant online-tACS theta band, gamma offline-tACS band. Moreover, were improved online- either prefrontal posterior parietal cortical regions, further both enhanced executive function. Online-tACS cortex was effective performances, improvements appeared function perceptual-motor These findings suggested specific may effectively improve

Language: Английский

Citations

27
How to test for phasic modulation of neural and behavioural responses DOI Creative Commons
Benedikt Zoefel, Matthew H. Davis, Giancarlo Valente

et al.

NeuroImage, Journal Year: 2019, Volume and Issue: 202, P. 116175 - 116175

Published: Sept. 6, 2019

Research on whether perception or other processes depend the phase of neural oscillations is rapidly gaining popularity. However, it unknown which methods are optimally suited to evaluate hypothesized effect. Using a simulation approach, we here test ability different detect such an effect dichotomous (e.g., "hit" vs "miss") and continuous scalp potentials) response variables. We manipulated parameters that characterise define experimental approach for this For each parameter combination variable, identified optimal method. found regressing single-trial responses circular (sine cosine) predictors perform best all simulated parameters, regardless nature variable (dichotomous continuous). In sum, our study lays foundation optimized designs analyses in future studies investigating role behavioural responses. provide MATLAB code statistical tested.

Language: Английский

Citations

60
Toward integrative approaches to study the causal role of neural oscillations via transcranial electrical stimulation DOI Creative Commons
Valeriia Beliaeva, Iurii Savvateev, Valerio Zerbi

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: April 14, 2021

Abstract Diverse transcranial electrical stimulation (tES) techniques have recently been developed to elucidate the role of neural oscillations, but critically, it remains questionable whether entrainment genuinely occurs and is causally related resulting behavior. Here, we provide a perspective on an emerging integrative research program across systems, species, theoretical experimental frameworks potential tES induce entrainment. We argue that such agenda requirement establish as tool test causal oscillations highlight critical issues should be considered when adopting translational approach.

Language: Английский

Citations

46
Working Memory and Transcranial-Alternating Current Stimulation—State of the Art: Findings, Missing, and Challenges DOI Creative Commons

Wiam Al Qasem,

Mohammed Abubaker, Eugen Kvašňák

et al.

Frontiers in Psychology, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 14, 2022

Working memory (WM) is a cognitive process that involves maintaining and manipulating information for short period of time. WM central to many processes declines rapidly with age. Deficits in are seen older adults patients dementia, schizophrenia, major depression, mild impairment, Alzheimer’s disease, etc. The frontal, parietal, occipital cortices significantly involved processing all brain oscillations implicated tackling tasks, particularly theta gamma bands. theta/gamma neural code hypothesis assumes retained items recorded via theta-nested cycles. Neuronal can be manipulated by sensory, invasive- non-invasive stimulations. Transcranial alternating-current stimulation (tACS) repetitive transcranial magnetic (rTMS) frequency-tuned (NIBS) techniques have been used entrain endogenous frequency-specific manner. Compared rTMS, tACS demonstrates superior cost, tolerability, portability, safety profile, making it an attractive potential tool improving performance. Although research still its infancy compared number studies shown promising enhancement effect, especially the elderly deficits. This review focuses on various methods outcomes healthy unhealthy human highlights established findings, unknowns, challenges, perspectives important translating laboratory into realistic clinical settings. will allow researchers identify gaps literature develop protocols efficacy outcomes. Therefore, efforts this direction should help consider as non-pharmacological rehabilitation physiological aging

Language: Английский

Citations

23
Transcranial alternating current stimulation improves quality of life in Parkinson’s disease: study protocol for a randomized, double-blind, controlled trial DOI Creative Commons
Hongyu Zhang, Tingting Hou, Zhaohui Jin

et al.

Trials, Journal Year: 2024, Volume and Issue: 25(1)

Published: March 20, 2024

Abstract Background The neural cells in the brains of patients with Parkinson’s disease (PWP) display aberrant synchronized oscillatory activity within beta frequency range. Additionally, enhanced gamma oscillations may serve as a compensatory mechanism for motor inhibition mediated by and also reinstate plasticity primary cortex affected disease. Transcranial alternating current stimulation (tACS) can synchronize endogenous exogenous rhythms, thereby modulating cortical activity. objective this study is to investigate whether addition tACS multidisciplinary intensive rehabilitation treatment (MIRT) improve symptoms PWP so enhance quality life individuals based on central-peripheral-central theory. Methods present was randomized, double-blind trial that enrolled 60 aged between 45 70 years, who had Hoehn-Yahr scale scores ranging from 1 3. Participants were randomly assigned 1:1 ratio either + MIRT group or sham-tACS group. consisted two-week period followed 24-week follow-up period, resulting total duration twenty-six weeks. outcome measured change PDQ-39 baseline (T0) 4 weeks (T2), 12 (T3), 24 (T4) after completion intervention. secondary assessed changes MDS-UPDRS III at T0, end intervention (T1), T2, T3, T4. Additional clinical assessments mechanistic studies conducted tertiary outcomes. Discussion demonstrate overall functionality PWP, framework MIRT. it seeks establish potential correlation these therapeutic effects neuroplasticity alterations relevant brain regions. efficacy will be during order optimize its impact efficiency PWP. Trial registration Chinese Clinical Registry ChiCTR2300071969. Registered 30 May 2023.

Language: Английский

Citations

5
Tripod transcranial alternating current stimulation at 5-Hz to alleviate anxiety symptoms: A preliminary report DOI
Tien‐Wen Lee, Chiang‐Shan R. Li, Gerald Tramontano

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 360, P. 156 - 162

Published: May 29, 2024

Language: Английский

Citations

4