Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Osteoarthritis (OA) is a significant contributor to pain and disability worldwide. Pain the main complaint of OA patients attending clinic has large impact on their quality life economic standards. However, existing treatments for OA-related have not been shown achieve good relief. The focus preventing slowing progression so that problem can be resolved. caused by complex, with nature, location, duration, intensity changing as disease progresses. Previous research highlighted role various forms cell death, such apoptosis necrosis, in OA. Emerging studies identified additional novel pyroptosis, ferroptosis, necroptosis are linked Different types death contribute tissue damage impacting inflammatory responses, reactive oxygen species (ROS) production, calcium ion levels, ultimately leading development pain. Evidence suggests targeting could help alleviate patients. This review delves into complex mechanisms pain, explores relationship between different modes proposes viable strategy treatment these conditions, goal providing scientific references future drugs.

Language: Английский