Long Non-Coding RNA in the Pathogenesis of Cancers

Cells, Journal Year: 2019, Volume and Issue: 8(9), P. 1015 - 1015

Published: Sept. 1, 2019

The incidence and mortality rate of cancer has been quickly increasing in the past decades. At present, become leading cause death worldwide. Most cancers cannot be effectively diagnosed at early stage. Although there are multiple therapeutic treatments, including surgery, radiotherapy, chemotherapy, targeted drugs, their effectiveness is still limited. overall survival malignant low. It necessary to further study mechanisms for cancers, explore new biomarkers targets that more sensitive effective diagnosis, treatment, prognosis than traditional methods. Long non-coding RNAs (lncRNAs) a class RNA transcripts with length greater 200 nucleotides. Generally, lncRNAs not capable encoding proteins or peptides. LncRNAs exert diverse biological functions by regulating gene expressions transcriptional, translational, post-translational levels. In decade, it demonstrated dysregulated lncRNA profile widely involved pathogenesis many diseases, cancer, metabolic disorders, cardiovascular diseases. particular, have revealed play an important role tumor growth metastasis. Many shown potential diagnosis treatment cancers. This review aims briefly discuss latest findings regarding roles some certain lung, breast, liver, colorectal as well hematological malignancies neuroblastoma.

Language: Английский

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Insight Into the Prospects for RNAi Therapy of Cancer

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: March 16, 2021

RNA interference (RNAi), also known as gene silencing, is a biological process that prevents expression in certain diseases such cancer. It can be used to improve the accuracy, efficiency, and stability of treatments, particularly genetic therapies. However, challenges delivery oligonucleotide drug less accessible parts body high incidence toxic side effects are encountered. therefore imperative their target sites reduce harmful on noncancerous cells harness full potential. In this study, role RNAi treatment COVID-19, novel coronavirus disease plaguing many countries, has been discussed. This review aims ascertain mechanism application explore current therapy by identifying some cancer systems providing information for improvement. worth mentioning lipid-based exosomes have revolutionized reducing immunogenicity improving cellular affinity. A deeper understanding associated with provide new insights into development.

Language: Английский

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Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer

Molecular Therapy — Oncolytics, Journal Year: 2021, Volume and Issue: 23, P. 458 - 476

Published: Nov. 11, 2021

Gastric cancer (GC) is one of the most prevalent malignant tumor types and third leading cause cancer-related death worldwide. Its morbidity mortality are very high due to a lack understanding about its pathogenesis slow development novel therapeutic strategies. Long non-coding RNAs (lncRNAs) class with length more than 200 nt. They play crucial roles in wide spectrum physiological pathological processes by regulating expression genes involved proliferation, differentiation, apoptosis, cell cycle, invasion, metastasis, DNA damage, carcinogenesis. The aberrant lncRNAs has been found various types. A growing amount evidence demonstrates that many aspects GC pathogenesis, including occurrence, recurrence, indicating their potential role as biomarkers diagnosis, prognosis, targets GC. This review systematically summarizes biogenesis, biological properties, functions highlights critical clinical significance information may contribute better diagnostics treatments for

Language: Английский

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Down-regulation of lncRNA DNAJC3-AS1 inhibits colon cancer via regulating miR-214-3p/LIVIN axis

Bioengineered, Journal Year: 2020, Volume and Issue: 11(1), P. 524 - 535

Published: Jan. 1, 2020

Long non-coding RNAs (lncRNAs) play a key role in the development and metastasis of cancer. However, biological clinical significance lncRNA DNAJC3-AS1 colon cancer is still unknown. In this study, effects on cell proliferation, migration, invasion were evaluated by MTT assay, wound-healing transwell respectively. The relationship between DNAJC3-AS1, miR-214-3p LIVIN was predicted online software confirmed dual-luciferase reporter assay. We found that down-regulation inhibited proliferation cells induced growth arrest. Down-regulation also invasion, epithelial-mesenchymal transition (EMT) cells. Moreover, can bind to knockdown increased expression identified as target miR-214-3p. up-regulation protein suppressed activation NF-κB signaling pathway. Besides, reduced viability, EMT cells, while inhibitor could reverse these effects. pathway down-regulating be restored inhibitor. These findings suggested may promote progression regulating miR-214-3p/LIVIN axis. serve new biomarker therapeutic for cancer, stimulating research directions treatment options.

Language: Английский

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MicroRNA and ER stress in cancer

Seminars in Cancer Biology, Journal Year: 2021, Volume and Issue: 75, P. 3 - 14

Published: Jan. 9, 2021

Language: Английский

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The Mechanisms of lncRNA-Mediated Multidrug Resistance and the Clinical Application Prospects of lncRNAs in Breast Cancer

Cancers, Journal Year: 2022, Volume and Issue: 14(9), P. 2101 - 2101

Published: April 23, 2022

Breast cancer (BC) is a highly heterogeneous disease and presents great threat to female health worldwide. Chemotherapy one of the predominant strategies for treatment BC; however, multidrug resistance (MDR) has seriously affected or hindered effect chemotherapy. Recently, growing number studies have indicated that lncRNAs play vital varied roles in BC chemoresistance, including apoptosis, autophagy, DNA repair, cell cycle, drug efflux, epithelial-mesenchymal transition (EMT), epigenetic modification tumor microenvironment (TME). Although thousands been implicated chemoresistance BC, systematic review their regulatory mechanisms remains be performed. In this review, we systematically summarized MDR functions mediated from latest literature. These findings significantly enhance current understanding suggest they may promising prognostic biomarkers patients receiving chemotherapy, as well therapeutic targets prevent reverse chemoresistance.

Language: Английский

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LncRNA GAS6-AS1 facilitates tumorigenesis and metastasis of colorectal cancer by regulating TRIM14 through miR-370-3p/miR-1296-5p and FUS

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Aug. 12, 2022

Abstract Background Long non-coding RNAs (lncRNAs) are essential regulators of tumorigenesis and the development colorectal cancer (CRC). Here, we aimed to investigate role lncRNA GAS6-AS1 in CRC its potential mechanisms. Methods Bioinformatics analyses evaluated level colon cancer, correlation with clinicopathological factors, survival curve diagnostic value. qRT-PCR were performed detect samples cell lines. The CCK8, EdU, scratch healing, transwell assays animal experiments conducted function CRC. RNA immunoprecipitation (RIP) dual-luciferase reporter gene carried out reveal interaction between GAS6-AS1, TRIM14, FUS, miR-370-3p/miR-1296-5p. Results was greatly elevated positively associated unfavorable prognosis patients. Functionally, regulates proliferation, migration, invasion, epithelial-mesenchymal transition (EMT) vitro induces growth metastasis vivo. Moreover, exerted oncogenic by competitively binding miR-370-3p miR-1296-5p, thereby upregulating TRIM14. Furthermore, verified that TRIM14 both interact FUS stabilized mRNA recruiting FUS. Besides, rescue furtherly demonstrated facilitate progression regulating Conclusion Collectively, these findings demonstrate promotes TRIM14-mediated EMT via ceRNA network FUS-dependent manner, suggesting could be utilized as a novel biomarker therapeutic target for

Language: Английский

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The long non‐coding RNA HCG18 promotes the growth and invasion of colorectal cancer cells through sponging miR‐1271 and upregulating MTDH/Wnt/β‐catenin

Clinical and Experimental Pharmacology and Physiology, Journal Year: 2019, Volume and Issue: 47(4), P. 703 - 712

Published: Dec. 19, 2019

Abstract Long non‐coding RNAs (lncRNAs) have recently emerged as key regulators of the occurrence and progression various human cancers, including colorectal cancer. However, regulatory mechanism lncRNAs in tumorigenesis cancer remains poorly understood. In this study, we aimed to elucidate potential role lncRNA HCG18 Herein, found that expression was significantly upregulated tissues cell lines. Knockdown inhibited growth invasion cells, while its overexpression had opposite effect. Moreover, identified a sponge miR‐1271. Our results showed knockdown markedly miR‐1271 cells. Notably, inversely correlated with specimens. Further investigation revealed contributed enhancement MTDH/Wnt/β‐catenin signalling The antitumour effect inhibition reversed by or MTDH overexpression. Overall, our study demonstrate exerts oncogenic function enhancing via sponging miR‐1271, highlighting importance HCG18/miR‐1271/

Language: Английский

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LncRNA LINC00483 promotes gastric cancer development through regulating MAPK1 expression by sponging miR-490-3p

Biological Research, Journal Year: 2020, Volume and Issue: 53(1)

Published: April 15, 2020

Previous studies have shown that long noncoding RNA (lncRNA) LINC00483 was aberrantly expressed in human cancers, including gastric cancer. However, the regulatory mechanism of this lncRNA cancer remains largely unknown. The present study aimed to investigate effect on development and explore potential network LINC00483/microRNA (miR)-490-3p/mitogen-activated protein kinase 1 (MAPK1).Thirty patients with were recruited for tissues collection. expression levels LINC00483, miR-490-3p MAPK1 detected by quantitative real-time polymerase chain reaction or western blot. Cell viability, apoptosis, migration invasion determined MTT, flow cytometry, transwell assays blot, respectively. target association between confirmed luciferase reporter assay. Xenograft model established assess function vivo.LINC00483 increased cells. Knockdown inhibited cells but promoted apoptosis Moreover, overexpression attenuated knockdown development. could increase competitively sponging miR-490-3p. suppressed development, which abated introduction LINC00483. Besides, inhibition decreased xenograft tumor growth regulating miR-490-3p/MAPK1 axis.Knockdown vitro vivo increasing decreasing MAPK1, elucidating a novel understanding

Language: Английский

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Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15897 - 15897

Published: Nov. 2, 2023

Long noncoding RNAs (lncRNAs) are a subclass of composed more than 200 nucleotides without the ability to encode functional proteins. Given their involvement in critical cellular processes such as gene expression regulation, transcription, and translation, lncRNAs play significant role organism homeostasis. Breast cancer (BC) is second most common worldwide evidence has shown relationship between aberrant lncRNA BC development. One main obstacles control multidrug chemoresistance, which associated with deregulation multiple mechanisms efflux transporter activity, mitochondrial metabolism reprogramming, epigenetic regulation well apoptosis autophagy. Studies have large number pathways. However, underlying mechanism not clearly elucidated. In this review, we present principal chemoresistance that can be directly or indirectly regulated by lncRNA, highlighting importance controlling chemoresistance. Understanding these deep detail may interest clinical outcome patients could used therapeutic targets overcome therapy resistance.

Language: Английский

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