Chemistry - A European Journal,
Journal Year:
2023,
Volume and Issue:
29(51)
Published: July 4, 2023
Abstract
Optical
imaging
has
a
wide
range
of
applications
in
the
biomedical
field,
allowing
visualization
physiological
processes
and
helping
diagnosis
treatment
diseases.
Unexcited
light
source
technologies,
such
as
chemiluminescence
imaging,
bioluminescence
afterglow
have
attracted
great
attention
recent
years
because
absence
excitation
interference
their
application
advantages
high
sensitivity
signal‐to‐noise
ratio.
In
this
review,
latest
advances
unexcited
technology
for
are
highlighted.
The
design
strategies
luminescent
probes
improving
luminescence
brightness,
penetration
depth,
quantum
yield
targeting,
inflammation
tumor
liver
kidney
injury
bacterial
infection
introduced
detail.
research
progress
future
prospects
medical
further
discussed.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(24), P. 13966 - 14037
Published: Nov. 22, 2023
Phosphorescence,
characterized
by
luminescent
lifetimes
significantly
longer
than
that
of
biological
autofluorescence
under
ambient
environment,
is
great
value
for
biomedical
applications.
Academic
evidence
fluorescence
imaging
indicates
virtually
all
metrics
(sensitivity,
resolution,
and
penetration
depths)
are
improved
when
progressing
into
wavelength
regions,
especially
the
recently
reported
second
near-infrared
(NIR-II,
1000–1700
nm)
window.
Although
emission
probes
does
matter,
it
not
clear
whether
guideline
"the
wavelength,
better
effect"
still
suitable
developing
phosphorescent
probes.
For
tissue-specific
bioimaging,
long-lived
probes,
even
if
they
emit
visible
phosphorescence,
enable
accurate
visualization
large
deep
tissues.
studies
dealing
with
bioimaging
tiny
architectures
or
dynamic
physiopathological
activities,
prerequisite
rigorous
planning
long-wavelength
being
aware
cooperative
contribution
long
wavelengths
improving
spatiotemporal
depth,
sensitivity
bioimaging.
In
this
Review,
emerging
molecular
engineering
methods
room-temperature
phosphorescence
discussed
through
lens
photophysical
mechanisms.
We
highlight
roles
from
to
NIR-II
windows
toward
bioapplications.
To
appreciate
such
advances,
challenges
prospects
in
rapidly
growing
described.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: March 5, 2024
Fluorescence
imaging
in
the
second
near-infrared
window
(NIR-II)
is
burgeoning
because
of
its
higher
fidelity
monitoring
physiological
and
pathological
processes
than
clinical
visible/the
fluorescence
imaging.
Notably,
heavily
dependent
on
agents.
So
far,
indocyanine
green,
one
polymethine
dyes,
with
good
biocompatibility
renal
clearance
only
dye
approved
by
Food
Drug
Administration,
but
it
shows
relatively
low
NIR-II
brightness.
Importantly,
tremendous
efforts
are
devoted
to
synthesizing
dyes
for
preclinically
clinically.
They
have
shown
feasibility
customization
structure
properties
fulfill
various
needs
therapy.
Herein,
a
timely
update
special
focus
molecular
design
strategies
fluorescent,
photoacoustic,
multimodal
imaging,
offered.
Furthermore,
progress
sensing
biomarkers
even
reporting
drug
release
illustrated.
Moreover,
imaging-guided
therapies
summarized
regarding
chemo-,
photothermal,
photodynamic,
approaches.
In
addition,
artificial
intelligence
pointed
out
potential
expedite
development.
This
comprehensive
review
will
inspire
interest
among
wide
audience
offer
handbook
people
an
dyes.
EBioMedicine,
Journal Year:
2023,
Volume and Issue:
89, P. 104476 - 104476
Published: Feb. 16, 2023
Surgery
is
the
cornerstone
of
colorectal
cancer
(CRC)
treatment,
yet
complete
removal
tumour
remains
a
challenge.
The
second
near-infrared
window
(NIR-II,
1000-1700
nm)
fluorescent
molecular
imaging
novel
technique,
which
has
broad
application
prospects
in
surgical
navigation.
We
aimed
to
evaluate
ability
CEACAM5-targeted
probe
for
CRC
recognition
and
value
NIR-II
imaging-guided
resection.We
constructed
2D5-IRDye800CW
by
conjugated
anti-CEACAM5
nanobody
(2D5)
with
dye
IRDye800CW.
performance
benefits
at
were
confirmed
experiments
mouse
vascular
capillary
phantom.
Then
subcutaneous
model
(n
=
15),
orthotopic
peritoneal
metastasis
10)
investigate
biodistribution
differences
between
NIR-I
vivo,
then
resection
was
guided
fluorescence.
Fresh
human
specimens
incubated
verify
its
specific
targeting
ability.2D5-IRDye800CW
had
an
fluorescence
signal
extending
1600
nm
bound
specifically
CEACAM5
affinity
2.29
nM.
In
vivo
imaging,
accumulated
rapidly
(15
min)
could
identify
metastases.
All
tumours
resected
under
guidance,
even
smaller
than
2
mm
detected,
higher
tumour-to-background
ratio
(2.55
±
0.38,
1.94
0.20,
respectively).
precisely
CEACAM5-positive
tissue.2D5-IRDye800CW
combined
translational
potential
as
aid
improve
R0
surgery
cancer.This
study
supported
Beijing
Natural
Science
Foundation
(JQ19027),
National
Key
Research
Development
Program
China
(2017YFA0205200),
(NSFC)
(61971442,
62027901,
81930053,
92059207,
81227901,
82102236),
(L222054),
CAS
Youth
Interdisciplinary
Team
(JCTD-2021-08),
Strategic
Priority
Chinese
Academy
Sciences
(XDA16021200),
Zhuhai
High-level
Health
Personnel
Project
(Zhuhai
HLHPTP201703),
Fundamental
Funds
Central
Universities
(JKF-YG-22-B005)
Capital
Clinical
Characteristic
Application
(Z181100001718178).
authors
would
like
acknowledge
instrumental
technical
support
multi-modal
biomedical
experimental
platform,
Institute
Automation,
Sciences.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 12, 2024
Abstract
The
lanthanide
complex,
characterized
by
narrow
emission
bands,
large
Stokes
shifts,
long
luminescence
lifetime,
robust
resistance
to
photobleaching,
and
magnetic
properties,
affords
significant
promise
for
molecular
imaging
biosensing
applications.
While
most
complexes
emitting
visible
light
are
extensively
studied
cellular‐level
detection
bioimaging,
near‐infrared‐emitted
(700–1700
nm)
compounds
exhibit
more
favorable
properties
bioimaging
biosensing,
ascribed
from
deeper
penetration
reduced
bleaching
effects.
Besides,
the
complex
with
higher
resonance
signals
can
enhance
image
resolution
sensitivity,
offering
precise
analysis.
However,
widespread
use
of
high‐efficiency
is
currently
impeded
lack
design
approaches
improving
sensitization
chromophores
extended
excitation
wavelengths.
In
this
review,
some
fundamental
theories
strategies
summarized
imaging,
lifetime‐engineered
dual‐modal
now
highlight
a
selection
review
addresses
existing
gap
in
literature
proposing
feasible
fluorescent
properties.
Concurrently,
future
challenges
opportunities
field
probes
discussed.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(4), P. 4478 - 4492
Published: Jan. 19, 2024
Small-molecule
dyes
for
fluorescence
imaging
in
the
second
near-infrared
region
(NIR-II,
900-1880
nm)
hold
great
promise
clinical
applications.
Constructing
donor-acceptor-donor
(D-A-D)
architectures
has
been
recognized
to
be
a
feasible
strategy
achieve
NIR-II
fluorescence.
However,
development
of
via
such
scheme
is
hampered
by
lack
high-performance
electron
acceptors
and
donors.
Diketopyrrolopyrrole
(DPP),
as
classic
organic
optoelectronic
material,
enjoys
strong
light
absorption,
high
quantum
yield
(QY),
facile
derivatization.
Nevertheless,
its
application
field
hindered
limited
electron-withdrawing
ability
aggregation-caused
quenching
(ACQ)
effect
resulting
from
planar
structure
DPP.
Herein,
with
DPP
an
acceptor
through
donor
engineering,
we
have
successfully
designed
synthesized
DPP-based
dye
named
T-27,
which
D-A
interaction
confers
excellent
NIR
absorption
high-brightness
tail
emission.
By
strategically
introducing
long
alkyl
chains
on
unit
increase
intermolecular
spacing
reduce
influence
solvent
molecules,
T-27
exhibits
improved
anti-ACQ
aqueous
solutions.
After
being
encapsulated
into
DSPE-PEG2000,
nanoparticles
(NPs)
show
relative
QY
3.4%
water,
representing
highest
value
among
reported
date.
The
outstanding
photophysical
properties
NPs
enable
multimode
NIR-IIa
bioimaging
under
808
nm
excitation.
As
such,
can
distinguish
mouse
femoral
vein
artery
cerebral
vascular
microscopic
penetrating
depth
800
μm,
demonstrating
capability
high-resolution
deep-tissue
imaging.
This
work
holds
significant
potential
provides
new
developing
bright
dyes.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
20, P. 100646 - 100646
Published: May 2, 2023
Lanthanide
nanomaterials
have
garnered
significant
attention
from
researchers
among
the
main
near-infrared
(NIR)
fluorescent
due
to
their
excellent
chemical
and
fluorescence
stability,
narrow
emission
band,
adjustable
luminescence
color,
long
lifetime.
In
recent
years,
with
preparation,
functional
modification,
improvement
of
lanthanide
materials,
great
progress
has
been
made
in
application
biomedical
field.
This
review
focuses
on
latest
tumor
diagnosis
treatment,
as
well
interaction
mechanism
between
biological
tissues.
We
introduce
a
set
efficient
strategies
for
improving
properties
discuss
some
representative
in-depth
research
work
detail,
showcasing
superiority
early
detection
ultra-small
tumors,
phototherapy,
real-time
guidance
surgical
resection.
However,
only
realized
portion
potential
applications
so
far.
Therefore,
we
promising
methods
further
performance
future
development
directions.
